One-pot synthesis of Hantzsch dihydropyridines using a highly efficient and stable PdRuNi@GO catalyst

Demirci, Tuna; Çelik, Betül; Yıldız, Yunus; Eriş, Sinan; Arslan, Mustafa; Sen, Fatih; Kılbaş, Benan

doi:10.1039/c6ra13142e

Cited by 87 publications

(24 citation statements)

References 47 publications

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“…While the reaction can be traditionally effected with protonic or Lewis acidic catalysts, there have been an urgent need to develop new and efficient catalytic systems to perform this transformation. In this regard plenty of representative catalysts have been developed for Hantzsch reaction, including LiBr, sulfated polyborate, Fe‐TUD‐1, PPA‐SiO 2 , nanoZnO, BiBr 3 , MOFs,, Cu‐NP/C, nano‐γ‐Fe 2 O 3 ,, LTNPs, [Ru(bpy) 3 ] 2+ , and others . However, despite the efficiency of these protocols, most of them still suffer from problems including cumbersome operation and corrosive environment.…”

Section: Methodsmentioning

confidence: 99%

Novel and Effective Strategy of Multifunctional Titanium Incorporated Mesoporous Material Supported Ionic Liquid Mediated Reusable Hantzsch Reaction

et al. 2019

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Mesoporous material supported functionalized ionic liquids have been designed and synthesized, characterized and evaluated as novel heterogeneous catalysts for the Hantzsch reaction. The as-fabricated catalysts show good performance in the Hantzsch synthesis of 1,4-dihydropyridines under ambient conditions, especially the titanium incorporated mesoporous material supported ionic liquid Ti-SBA-15@IL-BF 4 , based on a synergetic effect of titanium site of mesoporous material carrier and the acidic sites of ionic liquid. In addition, the heterogeneous catalyst offers simple operation for recovery and the recycling test showed that it could be reused for five times without significant loss of catalytic activity.

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Section: Methodsmentioning

confidence: 99%

Novel and Effective Strategy of Multifunctional Titanium Incorporated Mesoporous Material Supported Ionic Liquid Mediated Reusable Hantzsch Reaction

et al. 2019

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“…The activity of catalyst was sustained without loss up to 6 cycles. Demirci et al., reported PdRuNi@GO as a reusable catalyst for the synthesis of pyridine derivatives, the reaction was performed in DMF as a solvent at 70 °C to get the yields of 93 % in 45 min, the catalyst activity was lost after 5 cycles, whereas with AAPTMS/m‐ZrO 2 the reaction was done in water at the same 70 °C to get the yields of 80–95 % in 1–3 h in ethanol as a green solvent, more over the catalyst was reused up to 6 cycles. This protocol provides the efficient greener way to synthesize the pyridine derivatives with excellent catalytic stability.…”

Section: Zirconia Supported Mixed Oxidesmentioning

confidence: 99%

Our Contributions in Synthesis of Diverse Heterocyclic Scaffolds by Using Mixed Oxides as Heterogeneous Catalysts

Bhaskaruni

Gangu

Maddila

et al. 2018

The Chemical Record

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This personal account mainly introduces and reviews our recent contributions in developing different catalyst materials involving mixed oxides and their scope as renewable catalysts in multicomponent reactions to synthesize various novel heterocyclic scaffolds under green conditions. The application of various mixed oxides and their composites in the organic synthesis is emphasized through this review, in order to reveal the versatility, scope and importance of mixed oxides and their interactions during the reaction. We have also briefed the limitations of mixed oxides as catalysts, to put forward the broader prospective in the field.

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“…The biotechnological and nanotechnological advances have recently begun to be used in many areas such as biosensors, artificial implants, nanocatalysts, purification strategies and drug delivery system (Demirci et al 2016;Ayranci et al 2017a, b;Sahin et al 2018;Karatepe et al 2016;Aday et al 2016a, b;Yildiz et al 2016aYildiz et al , b, c, d, e, 2017aErken et al 2015;Baskaya et al 2017a, b;Celik et al 2016a, b, c;Abrahamson et al 2013;Demir et al 2017a, b;Erken et al 2016a, b;Akocak et al 2017;Eris et al 2018a, b, c;Esirden et al 2015;Goksu et al 2016aGoksu et al , b, c, 2017Sen et al 209 Page 2 of 12 , 2011a, b, 2012a, b, c, 2013a, b, c, 2014a, b, c, d, e, f, 2018aMittal et al 2010;Gupta et al 2011Gupta et al , 2014aGupta et al , b, 2015Saleh and Gupta 2011, b, 2014Khani et al 2010;Saravanan et al 2013aSaravanan et al , b, c, d, e, 2015aSaravanan et al , b, 2016aDevaraj et al 2016;Gupta and Saleh 2013;Erkan et al 2006;Bozkurt et al 2017;Pamuk et al 2015;Sahin et al 2017;Dasdelen et al 2017;Iverson et al 2013;…”

Section: Introductionmentioning

confidence: 99%

Immobilization kinetics and mechanism of bovine serum albumin on diatomite clay from aqueous solutions

et al. 2018

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In this research, adsorption properties of bovine serum albumin (BSA) on diatomite clay, which is an oxide mineral, were studied as a function of BSA, sodium phosphate buffer and protein concentration and pH and the thermodynamic parameters of adsorption process were investigated. The BSA adsorption experiment onto diatomite clay indicated that the BSA solution reached the maximum adsorption value at pH 5.5. It was observed that the maximum adsorption capacity (qm) of the data obtained from the adsorption studies showed a great dependence on pH. The maximum amount of adsorption in adsorption experiments can be considered as points where the electrostatic interaction for pH is appropriate. Both structural and electrostatic interaction in regions outside of the isoelectric point may have caused a decrease in BSA absorbance. The structural influences were associated with different conformational states that while BSA molecules accept changes with pH, electrostatic effects can be observed in BSA molecules behaved like soft particles. In this case, it is not possible to explain the independence of the qm-pH curves of the amount of adsorption. The protein molecules at this point are very stable. Because this value is close to the isoelectric point of serum albumin. The surface structural change of BSA and diatomite clay was studied. For this, Fourier transform infrared spectroscopy (FTIR) spectroscopy values were compared before and after the experiment. The diatomite samples used as support material were characterized by FTIR, scanning electron microscopy, thermogravimetric analysis and Brunauer Emmett-Teller surface area analysis. The thermodynamic functions such as enthalpy, entropy, Gibbs free energy and activation energy were investigated in their experimental work. The thermodynamic parameters such as Gibbs free energy (ΔG*), E a , ΔH* and ΔS* were calculated as − 67.45, 15.41, − 12.84 kJ mol −1 and − 183.28 J mol −1 K −1 for BSA adsorption, respectively. We can deduce that the adsorption process from the data obtained from the thermodynamic parameters is spontaneous and exothermic. The adsorption of the process was investigated using Eyring and Arrhenius equations, and its adsorption kinetic found to be coherent with the pseudo-second-order model. As a result, we reached that the diatomite clay is a suitable adsorbent for the BSA. Experimental results showed that diatomite clay has the potency to be used for rapid pretreatment in the process of identifying proteins.keywords Adsorption · Diatomite clay · Thermodynamic · Protein * Mehmet Salih Nas

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One-pot synthesis of Hantzsch dihydropyridines using a highly efficient and stable PdRuNi@GO catalyst

Abstract: The method for the synthesis of 1,4-dihydropyridine compounds in the presence of Pd–Ni–Ru@GO was developed, which is simple, effective and productive.

Cited by 87 publications

References 47 publications

Novel and Effective Strategy of Multifunctional Titanium Incorporated Mesoporous Material Supported Ionic Liquid Mediated Reusable Hantzsch Reaction

Novel and Effective Strategy of Multifunctional Titanium Incorporated Mesoporous Material Supported Ionic Liquid Mediated Reusable Hantzsch Reaction

Our Contributions in Synthesis of Diverse Heterocyclic Scaffolds by Using Mixed Oxides as Heterogeneous Catalysts

Immobilization kinetics and mechanism of bovine serum albumin on diatomite clay from aqueous solutions

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