One-pot synthesis of carbon dots with intrinsic folic acid for synergistic imaging-guided photothermal therapy of prostate cancer cells

Abstract

Photothermal therapy (PTT) is performed using near-infrared-responsive agents, which is proven to be an effective therapeutic strategy against cancer with several advantages including minimal invasion, high effectiveness, and easy implementation.

Molecular nature of breakdown of the folic acid under hydrothermal treatment: a combined experimental and DFT study

“…Thus far, most of the publications on the subject of HT treatment of FA for the purpose of enhanced fluorescence report changes observed in the UV-VIS absorption signal and in the light emission in the blue range of the optical spectrum [3][4][5][6]10 . Significantly, the emission is typically found to be excitation-independent in contrast to the carbon dots prepared from other precursors 11,12 , while quantum yield reaches values of over 90% 3,5 .…”

Recent Advances in Carbon Nanodots: A Promising Nanomaterial for Biomedical Applications

“…CNDs have also demonstrated potential in photothermal therapy [35,36,[63][64][65][66][67][68]. This process usually involves using a NIR laser to illuminate a tumor.…”

<p>Phytochemical-Based Nanomedicine for Advanced Cancer Theranostics: Perspectives on Clinical Trials to Clinical Use</p>

“…Nanodrug constructs also facilitate the enhanced localization of tumors as contrast agents as well as efficient delivery of different anticancer therapeutics under control of external (UV-rays, X-ray, laser ray) or internal (pH, temperature, redox) stimuli for surgically impervious malignant tumors. [56][57][58][59] Numerous plant-based anticancer nanoformulations have been approved by the FDA, and dozens are in clinical trials. Most recently approved nanomedicine core materials are based on previously approved conventional drugs.…”

“…The use of nanocarriers such as liposomes, micelle, dendrimers, nanodispersions, polymeric nanoparticles, nanotubes, nanorods, and metallic/non-metallic nanoparticles has ineluctably impacted cancer pharmacology. 59 Phytomolecules conjugated anti-neoplastic drugs in nanosize diffuse through the cell membrane escaping immune defense mechanism is known as passive targeting as depicted in Figure 4. Phyto-nanocomposite circulates through the cytoplasm, diffuse into intracellular organelles inducing oxidative stress and loss of mitochondrial membrane potential, progressing apoptosis in cancer cells.…”