&lt;p&gt;Phytochemical-Based Nanomedicine for Advanced Cancer Theranostics: Perspectives on Clinical Trials to Clinical Use&lt;/p&gt;

Dhupal, Madhusmita; Chowdhury, Devasish

doi:10.2147/ijn.s259628

Cited by 57 publications

(32 citation statements)

References 81 publications

(86 reference statements)

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“…The DNA damage in tumor cells treated with CPT and its derivatives is most likely caused by double-strand breaks introduced by the replication process [ 25 , 52 ]. Therefore, CPT also has been engaged for the treatment of ovarian and lung cancer [ 53 ]. On the other hand, BA is involved in treatment of cancer, HIV, and bacterial diseases.…”

Section: Major Medicinal Plants With Anticancer Activities and Possib...mentioning

confidence: 99%

Plants in Anticancer Drug Discovery: From Molecular Mechanism to Chemoprevention

Siddiqui

Jahan

Singh

et al. 2022

BioMed Research International

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Cancer is one of the primary causes of mortality globally, and the discovery of new anticancer drugs is the most important need in recent times. Natural products have been recognized as effective in fight against various diseases including cancer for over 50 years. Plants and microbes are the primary and potential sources of natural compounds to fight against cancer. Moreover, researches in the field of plant-based natural compounds have moved towards advanced and molecular level understandings from the last few decades, leading to the development of potent anticancer agents. Also, plants have been accepted as abundant and prosperous sources for the development of novel therapeutic agents for the management and prevention of different cancer types. The high toxicity of some cancer chemotherapy drugs, as well as their unfavorable side effects and drugs resistance, drives up the demand for natural compounds as new anticancer drugs. In this detailed evidence-based mechanistic review, facts and information about various medicinal plants, their bioactive compounds with their potent anticancer activities against different cancers have been gathered, with further approach to represent the molecular mechanism behind the anticancer activity of these plants. This review will be beneficial for investigators/scientists globally involved in the development of natural, safe, effective, and economical therapeutic agents/drugs against various cancers. This might be an important contribution in the field of drug discovery, where drugs can be used alone or in combination to increase the efficacy of newly synthesized drugs.

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Section: Major Medicinal Plants With Anticancer Activities and Possib...mentioning

confidence: 99%

Plants in Anticancer Drug Discovery: From Molecular Mechanism to Chemoprevention

Siddiqui

Jahan

Singh

et al. 2022

BioMed Research International

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“…The use of curcumin in the targeting and prevention of different aging related pathological situations has been frequently recorded [ 104 ]. These states consist of inflammation, cardiovascular disease, oxidative stress, type-2 diabetes, rheumatoid arthritis, ocular disease, atherosclerosis, osteoporosis, neurodegenerative diseases, and cancer.…”

Section: Nano-based Formulation Of Phyto-bioactive Used In Breast Cancer Preventionmentioning

confidence: 99%

Impacting the Remedial Potential of Nano Delivery-Based Flavonoids for Breast Cancer Treatment

et al. 2021

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Breast cancer persists as a diffuse source of cancer despite persistent detection and treatment. Flavonoids, a type of polyphenol, appear to be a productive option in the treatment of breast cancer, because of their capacity to regulate the tumor related functions of class of compounds. Plant polyphenols are flavonoids that appear to exhibit properties which are beneficial for breast cancer therapy. Numerous epidemiologic studies have been performed on the dynamic effect of plant polyphenols in the prevention of breast cancer. There are also subclasses of flavonoids that have antioxidant and anticarcinogenic activity. These can regulate the scavenging activity of reactive oxygen species (ROS) which help in cell cycle arrest and suppress the uncontrolled division of cancer cells. Numerous studies have also been performed at the population level, one of which reported a connection between cancer risk and intake of dietary flavonoids. Breast cancer appears to show intertumoral heterogeneity with estrogen receptor positive and negative cells. This review describes breast cancer, its various factors, and the function of flavonoids in the prevention and treatment of breast cancer, namely, how flavonoids and their subtypes are used in treatment. This review proposes that cancer risk can be reduced, and that cancer can be even cured by improving dietary intake. A large number of studies also suggested that the intake of fruit and vegetables is associated with reduced breast cancer and paper also includes the role and the use of nanodelivery of flavonoids in the healing of breast cancer. In addition, the therapeutic potential of orally administered phyto-bioactive compounds (PBCs) is narrowed because of poor stability and oral bioavailability of compounds in the gastrointestinal tract (GIT), and solubility also affects bioavailability. In recent years, creative nanotechnology-based approaches have been advised to enhance the activity of PBCs. Nanotechnology also offers the potential to become aware of disease at earlier stages, such as the detection of hidden or unconcealed metastasis colonies in patients diagnosed with lung, colon, prostate, ovarian, and breast cancer. However, nanoformulation-related effects and safety must not be overlooked. This review gives a brief discussion of nanoformulations and the effect of nanotechnology on herbal drugs.

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“…Among the main strategies for tumor treatment, chemotherapy has attracted much attention, because chemotherapy can compensate the shortcomings of surgical tumor treatment, such as tumor recurrent and metastasis. So far, various types of chemotherapeutic agents have been developed and used in clinical settings [ 1 , 2 , 3 ]. However, most chemotherapeutic agents have no inherent tumor targetability, which causes an adverse effect due to a high dose administration.…”

Section: Introductionmentioning

confidence: 99%

Design of a Platelet-Mediated Delivery System for Drug-Incorporated Nanospheres to Enhance Anti-Tumor Therapeutic Effect

Emi

Tabata

2021

Pharmaceutics

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The objective of this study is to construct a platelet-mediated delivery system for drug-incorporated nanospheres. Nanospheres of poly(lactic-co-glycolic acid) (PLGA-NS) with different sizes and surface properties were prepared by changing the preparation parameters, such as the type of polymer surfactant, the concentration of polymer surfactant and PLGA, and the stirring rate. When incubated with platelets, PLGA-NS prepared with poly(vinyl alcohol) suppressed the platelet activation. Scanning electron microscopic and flow cytometry examinations revealed that platelets associated with PLGA-NS (platelet hybrids, PH) had a similar appearance and biological properties to those of the original platelets. In addition, the PH with PLGA-NS specifically adhered onto the substrate pre-coated with fibrin to a significantly great extent compared with PLGA-NS alone. When applied in an in vitro model of tumor tissue which was composed of an upper chamber pre-coated with fibrin and a lower chamber culturing tumor cells, the PH with PLGA-NS incorporating an anti-tumor drug were delivered to the tumor cells through the specific adhesion onto the upper chamber and, consequently, drug release from the upper chamber took place, resulting in the growth suppression of tumor cells. It is concluded that the drug delivery system based on PH is promising for tumor treatment.

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<p>Phytochemical-Based Nanomedicine for Advanced Cancer Theranostics: Perspectives on Clinical Trials to Clinical Use</p>

Cited by 57 publications

References 81 publications

Plants in Anticancer Drug Discovery: From Molecular Mechanism to Chemoprevention

Plants in Anticancer Drug Discovery: From Molecular Mechanism to Chemoprevention

Impacting the Remedial Potential of Nano Delivery-Based Flavonoids for Breast Cancer Treatment

Design of a Platelet-Mediated Delivery System for Drug-Incorporated Nanospheres to Enhance Anti-Tumor Therapeutic Effect

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