One-pot synthesis of biomimetic glutathione peroxidase with temperature responsive catalytic behaviors

Abstract

A microgel-based biomimetic glutathione peroxidase with temperature responsive catalytic behavior is synthesized by integrating atom transfer radical polymerization (ATRP) technology into one-pot synthesis.

Preparation and catalytic behavior of antioxidant cassava starch with selenium active sites and hydrophobic microenvironments

“…Our group and other researchers have devoted considerable efforts to produce a series of biomimetic GPx using small molecules, 20,21 polymers, 22,23 proteins, 24,25 and nanomaterials, 26,27 and to expose the relationship between the structure and the function of biomimetic GPx. The previous results indicated that the three important catalytic factors for maintaining the high catalytic activity of GPx are the selenium element as the catalytic center on GPx, the hydrophobic microenvironment composed of hydrophobic amino acid residues such as 150 Phe, 148 Trp, and 34 Leu, and the recognition site for binding substrates via hydrogen bonds between substrates and arginine-based 40 Arg, 130 Arg, and 167 Arg.…”

Peroxidase‐like activity of an azamacrocyclic Ni(II) complex

“…[14][15][16][17][18][19][20][21][22] And also several organoselenium compounds mimicking glutathione peroxidase have been synthesized. [23][24][25][26][27][28][29] For last two decades, Ni-oxo and Ni-superoxo complexes have been isolated during the reactions between macrocyclic Ni complexes and dioxygen (O 2 ), showing the dioxygen activation ability of the Ni complexes. And Ni-superoxo and Ni-peroxo complexes have been synthesized by using H 2 O 2 and their reactivities and structural properties have been characterized.…”