One-pot synthesis of Au@TiO2 yolk-shell nanoparticles with enhanced photocatalytic activity under visible light

With advances in nanoparticle (NP) synthesis and engineering, nanoscale agents with both therapeutic and diagnostic functions have been increasingly exploited for cancer management. Herein, we synthesized a new type of zwitterionic polymer-gated Au@TiO 2 core-shell nanoparticles, which showed that they could selectively target and efficiently eliminate cancer cells via photothermal therapy (PTT), photodynamic therapy (PDT), pH/NIR-induced drug release, and cationic therapy. Methods : In the present study, the multifunctional therapeutic agent [Mn@P(CitAPDMAEMA)@Au@TiO 2 @DOX] was prepared to treat cancer with imaging-guided combination method. Firstly, Au@TiO 2 core-shell nanoparticles (NPs) were synthesized. Taking advantage of broad and strong photoabsorption and reactive oxygen species (ROS) generation, Au@TiO 2 core-shell NPs facilitated the single light-induced PTT and PDT. Next, a chemotherapy drug doxorubicin (DOX) was loaded into Au@TiO 2 core-shell NPs. Then, a biocompatible zwitterionic polymer P(CitAPDMAEMA) was grafted to improve the hemocompatibility of NPs and prolong the circulation time. The polymer also served as a capping or switching material for pH-triggered drug release. In addition, the cationic nature of P(CitAPDMAEMA) eased the binding to human cervical cancer (HeLa) cells and effectively inhibited their growth in acidic environments (termed cationic therapy). Moreover, with Mn 2+ ions immanently chelated, Mn@P(CitAPDMAEMA)@Au@TiO 2 @DOX NPs were able to provide enhanced contrast under T 1 - or T 2 -weighted magnetic resonance imaging (MRI). Results : The in vitro and in vivo anticancer experiments demonstrated the tumor was effectively inhibited with minimal side effects by the multifunctional NPs. Conclusions : As far as we know, this is the first presentation of four therapeutic methods into one nanomaterial, which will open up a new dimension for the design of combined treatment.

show abstract

“…The Au@TiO 2 core-shell NPs were prepared according to previous methods with some modification 35. The overall procedure is shown in Scheme S2.…”

Section: Resultsmentioning

confidence: 99%

Zwitterionic Polymer-Gated Au@TiO₂ Core-Shell Nanoparticles for Imaging-Guided Combined Cancer Therapy

Zheng

Wang

et al. 2019

Theranostics

View full text Add to dashboard Cite

show abstract

“…This increase in the binding energy of Ti-2p peaks indicates increased coordination of Ti with carbon quantum dots [33,36] in Au@TiO 2 @C. Figure 4(b) shows Au-4f peaks in Au@TiO 2 @C located at 83.8 and 87.5 eV. These peaks correspond to the splitting of 4f doublet of 3.7 eV in Au metal, [11,36,42] which indicates metallic characteristic of Au. The ambiguous peaks of Au were resulting by the thick shell of TiO 2 .…”

Section: Resultsmentioning

confidence: 93%

“…Titanium dioxide (TiO 2 ) is a widely studied transition metal oxides in the field of photocatalysis due to its superior electronic and catalytic properties, outstanding chemical stability and environment friendliness. [10,11] Though semiconductor photocatalysis has achieved significant advancement, but developing high quality green photocatalysts is still in great demand. There are two main problems in TiO 2 based photocatalysts: [1,12,13] TiO 2 is a wide-bandgap semiconductor with a band gap of 3.2 eV, therefore, it produces photo-induced electron and hole pairs only when stimulated by ultraviolet light.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Core‐Shell Au@TiO₂@C Nanoparticles and Their Photocatalytic Properties for the Degradation of Rhodamine B Under Simulated‐Solar Light

Wang

Wang³

et al. 2020

ChemistrySelect

View full text Add to dashboard Cite

A simple method to synthesize Au@TiO2@C core‐shell sandwich nanoparticles by hydrolysis and depositing carbon quantum dots (CQDs) is reported. The photocatalytic activity of the synthesized material was tested via degrading Rhodamine B (RhB) under simulated‐solar light irradiation. The degradation rate was found in the following order: Au@TiO2@C > P25 > Au@TiO2 > TiO2. The superior photocatalytic of Au@TiO2@C was attributed to synergistic effect of Au and CQDs. The CQDs layer coated outside benefits in improving absorption efficiency of solar light host and separation of electron‐holes pairs. The Au core can accelerate transfer process of photo excitons which can facilitate photocatalytic reaction.

show abstract

“…The typical broad absorption peaks are attributed to LSPR in the range 500-600 nm. 49,50 The broadening LSPR peaks originated not only from the broad size distributions of Au NCs (8-40 nm), which has been identied by TEM (vide supra), but also from the intercoupling of Au NCs. 51,52 The band gaps of as-prepared materials were estimated with Tauc plots (Fig.…”

Section: Resultsmentioning

confidence: 94%

Converting cellulose nanocrystals into photocatalysts by functionalisation with titanium dioxide nanorods and gold nanocrystals

et al. 2020

View full text Add to dashboard Cite

show abstract

One-pot synthesis of Au@TiO2 yolk-shell nanoparticles with enhanced photocatalytic activity under visible light

Cited by 46 publications

References 51 publications

Zwitterionic Polymer-Gated Au@TiO₂ Core-Shell Nanoparticles for Imaging-Guided Combined Cancer Therapy

Zwitterionic Polymer-Gated Au@TiO₂ Core-Shell Nanoparticles for Imaging-Guided Combined Cancer Therapy

Synthesis of Core‐Shell Au@TiO₂@C Nanoparticles and Their Photocatalytic Properties for the Degradation of Rhodamine B Under Simulated‐Solar Light

Converting cellulose nanocrystals into photocatalysts by functionalisation with titanium dioxide nanorods and gold nanocrystals

Contact Info

Product

Resources

About

One-pot synthesis of Au@TiO2 yolk-shell nanoparticles with enhanced photocatalytic activity under visible light

Cited by 46 publications

References 51 publications

Zwitterionic Polymer-Gated Au@TiO2 Core-Shell Nanoparticles for Imaging-Guided Combined Cancer Therapy

Zwitterionic Polymer-Gated Au@TiO2 Core-Shell Nanoparticles for Imaging-Guided Combined Cancer Therapy

Synthesis of Core‐Shell Au@TiO2@C Nanoparticles and Their Photocatalytic Properties for the Degradation of Rhodamine B Under Simulated‐Solar Light

Converting cellulose nanocrystals into photocatalysts by functionalisation with titanium dioxide nanorods and gold nanocrystals

Contact Info

Product

Resources

About

Zwitterionic Polymer-Gated Au@TiO₂ Core-Shell Nanoparticles for Imaging-Guided Combined Cancer Therapy

Zwitterionic Polymer-Gated Au@TiO₂ Core-Shell Nanoparticles for Imaging-Guided Combined Cancer Therapy

Synthesis of Core‐Shell Au@TiO₂@C Nanoparticles and Their Photocatalytic Properties for the Degradation of Rhodamine B Under Simulated‐Solar Light