One-pot synthesis of a microporous organosilica-coated cisplatin nanoplatform for HIF-1-targeted combination cancer therapy

Zhang, Xiaojuan; He, Chuanchuan; Liu, Xiaoguang; Chen, Yan; Zhao, Pengxuan; Chen, Chen; Yan, Ruicong; Li, Minsi; Fan, Ting; Altine, Bouhari; Tan, Yang; Lu, Yao; Lee, Robert J.; Gai, Yongkang; Xiang, Guangya

doi:10.7150/thno.41077

Cited by 32 publications

(20 citation statements)

References 32 publications

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“…Therefore, in cispatin therapy, it is important to inhibit the action of HIF-1 through the action of an inhibitor, e.g., acriflavine. Zhang et al developed a system in which the cisplatin core was coated with microporous silica in the reverse microemulsion method, and then tetrasulfide-bridged organic silica was incorporated (redox sensitive, degraded by reaction with glutathione) [96]. The nanoparticles were subsequently functionalized with a polymeric mPEG-silane, and finally the cationic acriflavine particles were electrostatically adsorbed on the negatively charged microporous silica coating.…”

Section: Combination Therapy Involving Cisplatin and Other Drugsmentioning

confidence: 99%

Nanoarchitectonics: Complexes and Conjugates of Platinum Drugs with Silicon Containing Nanocarriers. An Overview

Piorecka

Kurjata

Stańczyk

2021

IJMS

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The development in the area of novel anticancer prodrugs (conjugates and complexes) has attracted growing attention from many research groups. The dangerous side effects of currently used anticancer drugs, including cisplatin and other platinum based drugs, as well their systemic toxicity is a driving force for intensive search and presents a safer way in delivery platform of active molecules. Silicon based nanocarriers play an important role in achieving the goal of synthesis of the more effective prodrugs. It is worth to underline that silicon based platform including silica and silsesquioxane nanocarriers offers higher stability, biocompatibility of such the materials and pro-longed release of active platinum drugs. Silicon nanomaterials themselves are well-known for improving drug delivery, being themselves non-toxic, and versatile, and tailored surface chemistry. This review summarizes the current state-of-the-art within constructs of silicon-containing nano-carriers conjugated and complexed with platinum based drugs. Contrary to a number of other reviews, it stresses the role of nano-chemistry as a primary tool in the development of novel prodrugs.

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Section: Combination Therapy Involving Cisplatin and Other Drugsmentioning

confidence: 99%

Nanoarchitectonics: Complexes and Conjugates of Platinum Drugs with Silicon Containing Nanocarriers. An Overview

Piorecka

Kurjata

Stańczyk

2021

IJMS

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“…Also, these nanodiamonds prevented the efflux of Epirubicin by ABC transporters, enhancing drug retention that led to overcoming resistance triggered by the CHD4 gene [ 224 ] . In contrast, Zhang et al [ 225 ] (2020) developed PEGylated tetrasulfide organosilica shell nanoparticles, exploring the co-delivery of cisplatin and Acriflavine drugs to suppress HIF functions and inhibit metastasis. This delivery system was able to synergistically co-deliver the drugs into A549 adenocarcinoma lung cancer cells in vitro and in vivo.…”

Section: Drug Delivery Systems Using Nanoparticles To Improve the Effectiveness Of Chemotherapeutic Drugs In Resistant Tumorsmentioning

confidence: 99%

“…This delivery system was able to synergistically co-deliver the drugs into A549 adenocarcinoma lung cancer cells in vitro and in vivo. The results revealed the versatility of this system to combat anticancer drug resistance [ 225 , 226 ] . These nanocarrier designs demonstrate the effective incorporation of inorganic materials as a viable method to overcome anticancer drug resistance.…”

Section: Drug Delivery Systems Using Nanoparticles To Improve the Effectiveness Of Chemotherapeutic Drugs In Resistant Tumorsmentioning

confidence: 99%

Key genes and drug delivery systems to improve the efficiency of chemotherapy

Torres‐Martínez¹,

Delgado²,

Ferrer-Acosta³

et al. 2020

CDR

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Cancer cells can develop resistance to anticancer drugs, thereby becoming tolerant to treatment through different mechanisms. The biological mechanisms leading to the generation of anticancer treatment resistance include alterations in transmembrane proteins, DNA damage and repair mechanisms, alterations in target molecules, and genetic responses, among others. The most common anti-cancer drugs reported to develop resistance to cancer cells include cisplatin, doxorubicin, paclitaxel, and fluorouracil. These anticancer drugs have different mechanisms of action, and specific cancer types can be affected by different genes. The development of drug resistance is a cellular response which uses differential gene expression, to enable adaptation and survival of the cell to diverse threatening environmental agents. In this review, we briefly look at the key regulatory genes, their expression, as well as the responses and regulation of cancer cells when exposed to anticancer drugs, along with the incorporation of alternative nanocarriers as treatments to overcome anticancer drug resistance.

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“…Cisplatin chemotherapy [10] is often used for cancer and is a promising tumor treatment strategy. However, the long-term use of cisplatin [11] can also lead to drug resistance, [12] thereby severely impeding its therapeutic effectiveness and clinical transformation, showing a phenomenon of "drug-resistance".…”

Section: Introductionmentioning

confidence: 99%

Chemodynamic Therapy Combined with Multifunctional Nanomaterials and Their Applications in Tumor Treatment

Sun

et al. 2021

Chemistry A European J

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During the past few decades, radiotherapy and chemotherapy have been the standard approaches for tumor treatments. However, the potential toxic effect and side effects of both radiotherapy and chemotherapy on the human body still cannot be neglected. Given this, the Fenton reaction has become one of the most effective treatment strategies to combat tumor cells. This review aims to summarize the recent advances comprehensively and systematically in chemodynamic therapy (CDT) via the Fenton reaction. In addition, a host of the advanced nano-multifunctional materials and engineering bacteria used in the Fenton reaction were also summarized. This paper would be helpful to provide guidance and lay firm foundations for future tumor treatment.

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One-pot synthesis of a microporous organosilica-coated cisplatin nanoplatform for HIF-1-targeted combination cancer therapy

Cited by 32 publications

References 32 publications

Nanoarchitectonics: Complexes and Conjugates of Platinum Drugs with Silicon Containing Nanocarriers. An Overview

Nanoarchitectonics: Complexes and Conjugates of Platinum Drugs with Silicon Containing Nanocarriers. An Overview

Key genes and drug delivery systems to improve the efficiency of chemotherapy

Chemodynamic Therapy Combined with Multifunctional Nanomaterials and Their Applications in Tumor Treatment

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