One-pot synthesis of 4-substituted 4-alkoxy-1,4-dihydro-3,1-benzoxazine-2-thiones by the reaction of 2-isothiocyanatobenzoates with organolithiums

One-Pot Synthesis of Benzoxazines Through Mannich Condensations

“…Hence only washing with cold water after the completion of the reaction affords the desired products. On the other hand, in the present cases, the reaction time required is also much less compared to the earlier reported ones [15][16][17][18] . For instances, compound 2 has been reported to form by refluxing a mixture of corresponding phenol, amine and formaldehyde in toluene for 3 days.…”