One Pot, Solvent-Free Synthesis of Substituted 3,4-Dihydropyrimidin-2(1H)-Ones/Thiones under Microwave Irradiation (CEM) Using Reusable Nickel Nanoparticles

Abstract

Abstract:A library of 3,4-dihydropyrimidin-2(1H)-ones/thiones derivatives were synthesized via Biginelli condensation reaction of β-keto esters, aryl aldehydes and urea/thiourea under solvent-free conditions utilizing nickel nanoparticles under microwave irradiation (CEM Discover). The structures of the all compounds were elucidated with the aid of elemental analysis, IR, 1H-NMR and Mass spectral data. Nickel nanoparticles can be recovered and reused five times without loss of their efficiency. Short reaction time, high yield of products and simple workup procedure, solventfree conditions and reusability of the catalyst are the superior features of this protocol.

Multi‐component Reactions, Solvent‐free Synthesis of Substituted Pyrano‐pyridopyrimidine under Different Conditions Using ZnO Nanoparticles

“…Multi‐component reactions under solvent‐free conditions using ZnO nanoparticles as a catalyst presented itself as a remarkable technique toward environmentally clean synthesis of organic compounds . Herein, ZnO nanoparticles were used as a catalyst during the condensation reactions of aromatic aldehydes, 3H‐pyrido[1,2 ‐a ]pyrimidine‐2,4‐dione 1 and malononitrile in order to afford new moieties, namely, 2‐amino‐4‐(4‐substitutedphenyl)‐5‐oxo‐4H,5H‐pyrano[2,3 ‐d ]pyrido[1,2 ‐a ] pyrimidine‐3‐carbonitrile derivatives 2 – 12 (Scheme ).…”