One‐Pot Pseudo Five Component Synthesis of Biologically Relevant 1,2,6‐Triaryl‐4‐arylamino‐piperidine‐3‐ene‐3‐ carboxylates: A Decade Update

Abstract

Piperidines, an important class of N‐heterocycles, are very common in naturally occurring bioactive compounds. Recently, functionalized piperidines, specifically, 1,2,6‐triaryl‐4‐arylamino‐piperidine‐3‐ene‐3‐carboxylates have drawn considerable attention due to its diverse pharmacological efficacies that include anti‐cancer, anti‐microbial, anti‐oxidant, anti‐fungal, anti‐inflammatory and acetylcholinesterase (AChE) inhibitory activities. As a result, during the last decade, a number of methods reported for the synthesis of 1,2,6‐triaryl‐4‐arylamino‐piperidine‐3‐ene‐3‐carboxylates via one‐pot pseudo five‐component reactions of aromatic aldehydes, anilines and β‐keto esters under various reaction conditions. The present review deals with the ‘‘up to date” developments on the synthesis of 1,2,6‐triaryl‐4‐arylamino‐piperidine‐3‐ene‐3‐carboxylates reported so far.

Обзор Номенклатуры Лекарственных Средств На Основе Пиперидина И Морфолина

“…водных пиперидина [2,3,4,5,6,7,8,9,10,11,12,13,14], модификации [15] и их фармакологическим исследованиям [16,17,18]…”

Recent Developments on Five-Component Reactions

“…The Abbas lab reported a silica sulfuric acid (SSA)-catalyzed reaction for the syn Piperidine is a privileged N-heterocyclic ring and its derivatives possess diverse pharmacological activities such as anticancer, antimicrobial, antioxidant, antiinflammatory, and acetylcholinesterase inhibitory activities [59]. There are several papers on the synthesis of piperidine derivatives through the reaction of aromatic aldehydes, anilines, and β-keto esters under different conditions.…”

Synthesis and Biological Evaluation of Azacrownophanes Containing Tetrahydropyridine or Piperidone Subunits

“…Integration of bioactive heterocycles like piperidone, [15–16] pyrimidines, [17] γ ‐arylpyridine, [18–20] tetrahydropyridine… [21–23] into crown ether structures promises the enhancement of bioactivity and other interesting properties of such derivatives, especially regarding antimicrobial and antitumor properties. To our best knowledge, numerous studies about these tetrahydropyridine and piperidone derivatives were reported but mostly focused on their main function [14,24–26] . In our present studies, the efficient synthesis of crown ether compounds through the MCR of dialdehyde, β ‐keto esters and ammonium acetate are explored.…”

“…To our best knowledge, numerous studies about these tetrahydropyridine and piperidone derivatives were reported but mostly focused on their main function. [14,[24][25][26] In our present studies, the efficient synthesis of crown ether compounds through the MCR of dialdehyde, βketo esters and ammonium acetate are explored. New derivatives of azacrownophane were successfully prepared from that with the introduction of pharmacophoric moieties namely tetrahydropyridine or piperidone cores connected with flexible polyether spacers in their molecules.…”