One-pot process to Z-α-benzoylamino-acrylic acid methyl esters via potassium phosphate-catalyzed Erlenmeyer reaction

Functionalized 1,3‐Diaminotruxillic Acids by Pd‐Mediated C–H Activation and [2+2]‐Photocycloaddition of 5(4H)‐Oxazolones

“…The oxazolones shown in Figure were prepared following methods reported in the bibliography . A wide array of substrates was synthesized to cover the maximum number of possibilities, and the orthopalladation of all ligands was attempted.…”

“…HRMS and ESI (ESI+) mass spectra were recorded using an MicroToF Q, API‐Q‐ToF ESI with a mass range from 20 to 3000 m/z and mass resolution of 15000 (FWHM). The oxazolones containing the phenyl ring in the 2‐position ( 1a – 1i ), those containing the methyl group in the 2‐position ( 1j – 1o ), and the oxidation reagent PhICl 2 were prepared by reported procedures. Compounds 2l , 2n and 2o were prepared as described previously .…”

Silica‐supported Solvent Approaches More Facile than the Conventional for Erlenmeyer Synthesis with Our Pyridinium Salts

“…Greener approach is the construction of chemical compounds and processes that eliminate or minimize the generation and usage of environmental‐polluting substances . In literature, different routes were used including the use of several bases such as K 3 PO 4 , DIPEA , basic ILs , some of transition metal catalysis , and microwave‐assisted reactions , even though the conventional Erlenmeyer reaction that is still used to prepare oxazolone derivatives is very interesting. Herein, we wish to report the preparation of substituted pyridinium salts under conventional/silica‐supported solvent‐free muffle/microwave medium.…”

Microwave-Assisted Synthesis, Characterization, and Biological Evaluation of Phenylacrylamide Derivatives of Triazoles Derived From Oxazolones

“…Triazole moiety may be considered as a bioisostere of imidazole, which is a part of the azole group of antifungal drug (i.e., fluconazole). The 1, 2, 4-triazole nucleus has been incorporated into a wide variety of therapeutically important agents such as ribavirin (antiviral), rizatriptan (antimigraine), alprazolam (anxiolytic), vorozole, letrozole, and anastrozole (antitumoral) [11][12][13][14][15][16][17][18][19][20][21][22][23].…”

“…In the present study, our main objective was to use the microwave technology [13,24,25] and the final molecules were designed to combine both oxazolone and 1, 2, 4-triazole moieties that were expected to have synergistic antimicrobial and antioxidant activities. In view of the above facts and in continuation of our efforts, we here in report the synthesis and biological activity of N-(3-(4H-1,2,4-triazol-4-ylamino)-3-oxo-1arylidene prop-2-yl) benzimidic acids (7a-c).…”