Silica‐supported Solvent Approaches More Facile than the Conventional for Erlenmeyer Synthesis with Our Pyridinium Salts

Manikandan, Chitrarasu; Ganesan, Kilivelu

doi:10.1002/jhet.3120

Cited by 7 publications

(3 citation statements)

References 43 publications

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“…Synthesis of dimeric and trimeric substituted imidazolium cation with different anion is carried out using easily available starting materials under conventional as well as solvent free solid supported method [14]. Benzoxazole and its derivatives are prepared using very low concentration of catalyst (dimeric/trimeric substituted imidazolium salts).…”

Section: Novel 33 0 -(246-trimethyl-5-((2-methyl-5-nitro-1h-imidazol-...mentioning

confidence: 99%

Perspective Chapter: Applications of Novel Ionic Liquids as Catalyst

Ganesan¹

2023

Industrial Applications of Ionic Liquids

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Ionic liquids have much interesting attention in the area of biomedical and it’s an alternative to traditional organic solvents owing to their unique chemical, physical properties and environmentally eco-friendly catalytic responses. Ionic liquids have distinct properties like tunability that allows their physical and chemical behaviors to be changed as desired by changing the organic cations with inorganic anions or inorganic cations with organic anions or both cation and anion from organic moieties. Most of the organic reactions are carried out with assistance of catalyst, usually commercially available catalyst are very expensive, more hydroscopic in nature, thermally unstable and very difficult to recycle them but ionic liquids are acted as potential Lewis acidic behaviors, thermally stable, easily recycle inexpensive compared to commercial catalyst and easy to prepare electrically neutral organic cation which are loosely bind with inorganic anions, and organic (pyridinium/imidazolium/piperidinium) cation could be easily accelerate (or) activate the functional group for most of the organic reactions. Hence, ionic liquids plays a vital role in modern organic synthetic field and may be inevitable in future research.

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Section: Novel 33 0 -(246-trimethyl-5-((2-methyl-5-nitro-1h-imidazol-...mentioning

confidence: 99%

Perspective Chapter: Applications of Novel Ionic Liquids as Catalyst

Ganesan¹

2023

Industrial Applications of Ionic Liquids

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“…Organic cation like imidazolium, pyridinium and pyrazolium ion with simple inorganic anions are mostly used in pharma industries due to its unique physiochemical behaviors 2,3 . The quarternization of sp 2 nitrogen of pyridine and imidazole nucleus is the important method in the synthesis of ionic liquids [4][5][6][7][8][9][10] . Pyridine derivatives are very important and useful moieties to reach wide popularity in the Bronsted acidic ionic liquids to prepare the drug molecules [11][12][13][14][15][16][17][18] .…”

Section: Synthesis Of Potent Mda-mb 231 Breast Cancer Drug Molecules ...mentioning

confidence: 99%

Synthesis of potent MDA-MB 231 breast cancer drug molecules from single step

Govindaraj,

Ganesan,

Dharmasivam

et al. 2023

Sci Rep

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We have prepared novel potent breast cancer drug molecules from non-toxic and inexpensive method. Column chromatography is not necessary for purification of target molecules. The value of overall atom economy, environmental factor, environmental catalyst and product mass intensity gives additional merits for this synthetic method. Synthesized flexible dimeric imidazolium bromides showed less toxicity and gives excellent anticancer response against normal mammary epithelial cells. Novel dimeric pyridinium bromides showed excellent anticancer response against tested cancer cell lines. In cell cycle, novel flexible dimeric pyridinium bromides showed significant arrest in the G2/M phase by nearly three folds, when compared with control drug. We have studied the targeting epidermal growth factor receptor for all the synthesized flexible amino substituted and methyl substituted dimeric pyridinium bromides.

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“…The scope of their application is now broader and covers their use as reaction media, fuel cells, optical fluids, solar cells, energetic materials, heat transfer fluids, and lubricants, to name only a few . The properties of imidazolium/pyridinium salt are varied with different counter anions, which can enhance or suppress the catalytic activities. − Pyrazole and its derivatives have emerged as important compounds among the other heterocyclic compounds due to their medicinal properties like anti-inflammatory, , analgesic, , antimicrobial, anticancer, antiviral, antipyretic, and antianxiety activities, and some of the reports proved that adding other materials like nitrogen-containing phosphane , and ligands , to pyrazolium/pyridinium , and imidazolium − can give more stability to the compound, which are recyclable catalytic moieties. The drug discovery and evolution process aims at finding a compound, possessing good pharmacodynamic and pharmacokinetic properties.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization, Pharmacogenomics, and Molecular Simulation of Pyridinium Type of Ionic Liquids and Their Applications

et al. 2023

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Substituted pyridinium bromides are prepared by conventional and solvent-free greener methods. The solvent-free solid-phase (greener) method is superior to the conventional method because of its nontoxic nature, simple reaction setup procedure, and twenty times less time consumption. Column chromatography and toxic organic solvents are avoided. Substituted pyridinium salts 1−2(a−c) show excellent catalytic response in the preparation of β-amino carbonyl derivatives using the conventional approach. Pharmacokinetics is very important in target validation and in shifting a lead compound into a drug. The physicochemical properties discussed here can be used effectively in the drug designing candidate, which is a cumbersome process in clinical research. In addition, molecular simulations are demonstrated, and compounds 1−2(a−c) possess the most potent VEGFR-2 kinase protein inhibitory activities, and most interestingly, compound 2a strongly binds and regulates the VEGFR-2 kinase activity in therapeutic approaches and cancer prevention.

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Silica‐supported Solvent Approaches More Facile than the Conventional for Erlenmeyer Synthesis with Our Pyridinium Salts

Cited by 7 publications

References 43 publications

Perspective Chapter: Applications of Novel Ionic Liquids as Catalyst

Perspective Chapter: Applications of Novel Ionic Liquids as Catalyst

Synthesis of potent MDA-MB 231 breast cancer drug molecules from single step

Synthesis, Characterization, Pharmacogenomics, and Molecular Simulation of Pyridinium Type of Ionic Liquids and Their Applications

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