One-pot preparation of hyaluronic acid‐coated iron oxide nanoparticles for magnetic hyperthermia therapy and targeting CD44-overexpressing cancer cells

Soleymani, Meysam; Velashjerdi, Mohammad; Shaterabadi, Zhila; Barati, Aboulfazl

doi:10.1016/j.carbpol.2020.116130

Cited by 82 publications

(36 citation statements)

References 64 publications

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“…[ 79 ] Soleymani et al fabricated a nanotheranostic agent (Fe 3 O 4 @HA) by coating Fe 3 O 4 NPs with an HA ligand for hyperthermia therapy. [ 80 ] In this example, the obtained Fe 3 O 4 @HA exhibited long‐term stability under physiological condition (pH 7.4) and excellent biocompatibility against L929 normal cells as well as enhanced cellular internalization to CD44‐positive breast cancer cells. Moreover, Fe 3 O 4 @HA was endowed with a high heating capacity when exposed to the safe AMF.…”

Section: Biomedical Applicationsmentioning

confidence: 93%

Functionalization of Magnetic Nanoparticles with Organic Ligands toward Biomedical Applications

Yang

Lee

2021

Advanced NanoBiomed Research

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Functionalization of magnetic nanoparticles (MNPs) with organic ligands to prepare personalized nanomedicine has attracted tremendous attention in biomedical applications. These organic/MNP nanohybrid platforms not only can exert the superparamagnetic property of MNPs for diagnosis imaging and treatment, but are also endowed with the merits of organic ligands for improved tumor‐targeting ability, blood circulation time, and cellular uptake. Flexibly manipulating the interactions between different inorganic ligands and MNPs to establish a single MNP matrix or multiple MNP assemblies presents advanced strategies in controlling their composition and chemical–physical and biological properties for various biomedical applications. Beginning with a brief introduction to a variety of strategies for the efficient functionalization of MNPs with various organic ligands, herein, the recent progress in the development and biomedical applications of the different types of nanoplatforms of organic ligand–mediated MNPs is briefly introduced, including diagnosis, therapy, imaging‐guided therapy, and drug delivery. Finally, the future opportunities and challenges for next‐generation high‐performance organic ligand–functionalized MNP nanoplatforms are also discussed.

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Section: Biomedical Applicationsmentioning

confidence: 93%

Functionalization of Magnetic Nanoparticles with Organic Ligands toward Biomedical Applications

Yang

Lee

2021

Advanced NanoBiomed Research

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“…In particular, magnetite (Fe

) and maghemite (

-Fe

) are two main crystal phases, commonly used in various applications. The most common examples are magnetic resonance imaging [ 5 , 6 , 7 ], magnetic hyperthermia [ 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 ], drug delivery/release systems [ 16 , 17 , 18 ], immune response control [ 19 , 20 ], and environmental remediation [ 21 , 22 ]. There are several methods of preparing iron oxide nanoparticles [ 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 ], but their aqueous suspensions are often not stable and agglomerate quickly.…”

Section: Introductionmentioning

confidence: 99%

Filtration of Nanoparticle Agglomerates in Aqueous Colloidal Suspensions Exposed to an External Radio-Frequency Magnetic Field

et al. 2021

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The study investigated the phenomenon of the fast aggregation of single-domain magnetic iron oxide nanoparticles in stable aqueous colloidal suspensions due to the presence of a radio-frequency (RF) magnetic field. Single-domain nanoparticles have specific magnetic properties, especially the unique property of absorbing the energy of such a field and releasing it in the form of heat. The localized heating causes the colloid to become unstable, leading to faster agglomeration of nanoparticles and, consequently, to rapid sedimentation. It has been shown that the destabilization of a stable magnetic nanoparticle colloid by the RF magnetic field can be used for the controlled filtration of larger agglomerates of the colloid solution. Two particular cases of stable colloidal suspensions were considered: a suspension of the bare nanoparticles in an alkaline solution and the silica-stabilized nanoparticles in a neutral solution. The obtained results are important primarily for biomedical applications and wastewater treatment.

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“…Spatial structures of dendrimer-functionalized SPIONs (D-SPIONs), which are useful in conjugation with other chemicals and for encapsulation of drugs, serve as excellent imaging probes [ 11 , 12 ], such as for MRI, due to their prolonged half-life [ 13 ]. Moreover, the high colloidal stability and excellent biocompatibility of D-SPIONs are critical properties for MRI contrast media [ 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of Electromagnets on Bovine Corneal Endothelial Cells Treated with Dendrimer Functionalized Magnetic Nanoparticles

et al. 2021

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To improve bovine corneal endothelial cell (BCEC) migration, enhance cell energy, and facilitate symmetric cell distribution in corneal surfaces, an electromagnet device was fabricated. Twenty nanometer superparamagnetic iron oxide nanoparticles (SPIONs) functionalized with fourth-generation dendrimer macromolecules were synthesized, and their size and structure were evaluated using transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), and Fourier transform infrared spectroscopy (FTIR). The results confirmed the configuration of the dendrimer on the SPION surfaces. In vitro biocompatibility was assessed using the 3-[4,5-dimethylthiazol-2yl]-2,5-diphenyl tetrazolium bromide assay. No significant toxicity was noted on BCECs within 24 h of incubation. In the cell migration assay, cells treated with dendrimer-coated SPIONs exhibited a relatively high wound healing rate under sample addition (1 μg/mL) under a magnetic field. Real-time PCR on BCECs treated with dendrimer-coated SPIONs revealed upregulation of specific genes, including AT1P1 and NCAM1, for BCECs-dendrimer-coated SPIONs under a magnetic field. The three-dimensional dispersion of BCECs containing dendrimer-coated SPIONs under a magnetic field was evaluated using COMSOL Multiphysics software. The results revealed the BCECs-SPION vortex pattern layers in the corneal surface corresponded to the electromagnet’s displacement from the ocular surface. Magnetic resonance imaging (MRI) indicated that dendrimer-coated SPIONs can be used as a T2 contrast agent.

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One-pot preparation of hyaluronic acid‐coated iron oxide nanoparticles for magnetic hyperthermia therapy and targeting CD44-overexpressing cancer cells

Cited by 82 publications

References 64 publications

Functionalization of Magnetic Nanoparticles with Organic Ligands toward Biomedical Applications

Functionalization of Magnetic Nanoparticles with Organic Ligands toward Biomedical Applications

Filtration of Nanoparticle Agglomerates in Aqueous Colloidal Suspensions Exposed to an External Radio-Frequency Magnetic Field

Effects of Electromagnets on Bovine Corneal Endothelial Cells Treated with Dendrimer Functionalized Magnetic Nanoparticles

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