One-pot polyol synthesis of monosize PVP-coated sub-5nm Fe3O4 nanoparticles for biomedical applications

Liu, Hong Ling; Ko, Seung Pil; Wu, Jun; Jung, Myung Hun; Min, Ji Hyun; Lee, Ju Hun; An, Boo Hyun; Kim, Young Keun

doi:10.1016/j.jmmm.2006.10.776

Cited by 122 publications

(39 citation statements)

References 5 publications

(8 reference statements)

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“…Figure 5 shows the magnetization curves of bare and GC-coated IONPs recorded by VSM as a function of applied magnetic field (H, Oe). Both IONPs exhibit a well-defined superparamagnetic behavior at room temperature with zero coercivity or remanence, revealing that the thermal energy exceeded the anisotropic energy of IONPs [20,21,27]. Upon reducing the field, the magnetization value (M s ) dropped from the plateau and reached zero in zero field, implying that both IONPs are composed of single-crystal domains with aligned magnetic moments [10].…”

Section: Thermogravimetrymentioning

confidence: 99%

Synthesis, characterization and antibacterial activity of superparamagnetic nanoparticles modified with glycol chitosan

Inbaraj

Tsai

Chen

2012

Science and Technology of Advanced Materials

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Iron oxide nanoparticles (IONPs) were synthesized by coprecipitation of iron salts in alkali media followed by coating with glycol chitosan (GC-coated IONPs). Both bare and GC-coated IONPs were subsequently characterized and evaluated for their antibacterial activity. Comparison of Fourier transform infrared spectra and thermogravimetric data of bare and GC-coated IONPs confirmed the presence of GC coating on IONPs. Magnetization curves showed that both bare and GC-coated IONPs are superparamagnetic and have saturation magnetizations of 70.3 and 59.8 emu g −1 , respectively. The IONP size was measured as ∼ 8-9 nm by transmission electron microscopy, and their crystal structure was assigned to magnetite from x-ray diffraction patterns. Both bare and GC-coated IONPs inhibited the growths of Escherichia coli ATCC 8739 and Salmonella enteritidis SE 01 bacteria better than the antibiotics linezolid and cefaclor, as evaluated by the agar dilution assay. GC-coated IONPs showed higher potency against E. coli O157:H7 and Staphylococcus aureus ATCC 10832 than bare IONPs. Given their biocompatibility and antibacterial properties, GC-coated IONPs are a potential nanomaterial for in vivo applications.

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Section: Thermogravimetrymentioning

confidence: 99%

Synthesis, characterization and antibacterial activity of superparamagnetic nanoparticles modified with glycol chitosan

Inbaraj

Tsai

Chen

2012

Science and Technology of Advanced Materials

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“…Furthermore, aggregated nanoparticles change their superparamagnetic response [7]. Therefore, in order to minimize biofouling and aggregation of particles and escape from the RES for longer circulation times, the nanoparticles are usually coated with a layer of hydrophilic and biocompatible polymer such as dextran [18], dendrimers [19], poly(ethylene glycol) (PEG) [20], and poly(vinyl pyrrolidone) (PVP) [21][22][23]. Of synthetic polymers, PVP is water-soluble, non-charged, non-toxic, and is used in various medical applications [24].…”

mentioning

confidence: 99%

Synthesis and characterization of PVP-functionalized superparamagnetic Fe3O4 nanoparticles as an MRI contrast agent

Arsalani¹,

Fattahi²,

Nazarpoor³

2010

Express Polym. Lett.

229

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Abstract. The magnetite (Fe3O4) nanoparticles (MNPs) coated with poly(N-vinyl pyrrolidone) (PVP) via covalent bonds were prepared as T2 contrast agent for magnetic resonance imaging (MRI). The surface of MNPs was first coated with 3-(trimethoxysilyl) propyl methacrylate (silan A) by a silanization reaction to introduce reactive vinyl groups onto the surface, then poly(N-vinyl pyrrolidone) was grafted onto the surface of modified-MNPs via surface-initiated radical polymerization. The obtained nanoparticles were characterized by FT-IR (Fourier transform infrared spectroscopy), XRD (X-ray diffraction), TEM (transmission electron microscopy), VSM (vibrating sample magnetometer), and TGA (thermogravimetric analysis). The MNPs had an average size of 14 nm and exhibited superparamagnetism and high saturation magnetization at room temperature. T2-weighted MRI images of PVP-grafted MNPs showed that the magnetic resonance signal is enhanced significantly with increasing nanoparticle concentration in water. The r1 and r2 values per millimole Fe, and r2/r1 value of the PVP-grafted MNPs were calculated to be 2.6 , 72.1, and 28.1(mmol/l) -1 ·s -1 , respectively. These results indicate that the PVP-grafted MNPs have great potential for application in MRI as a T2 contrast agent. Vol.4, No.6 (2010) 329-338 Available online at www.expresspolymlett.com DOI: 10.3144/expresspolymlett.2010.42 region that they are accumulated, and hence cause negative contrast and provide a dark state in the image where the compounds are accumulated [15]. However, the direct use of magnetic nanoparticles as in vivo MRI contrast agent results in biofouling of the particles in blood plasma and formation of aggregates that are quickly sequestered by cells of the reticular endothelial system (RES) such as macrophages [16,17]. Furthermore, aggregated nanoparticles change their superparamagnetic response [7]. Therefore, in order to minimize biofouling and aggregation of particles and escape from the RES for longer circulation times, the nanoparticles are usually coated with a layer of hydrophilic and biocompatible polymer such as dextran [18], dendrimers [19], poly(ethylene glycol) (PEG) [20], and poly(vinyl pyrrolidone) (PVP) [21][22][23]. Of synthetic polymers, PVP is water-soluble, non-charged, non-toxic, and is used in various medical applications [24]. While there is a potential concern about covalent interaction between hydrophilic polymers and magnetic nanoparticles in order to increase their stability in physiological medium [25][26][27][28][29], PVP coating on Fe 3 O 4 nanoparticles in all previous works has been achieved through noncovalent interaction. Now, polymers grafting of magnetic nanoparticles is one of the most attractive methods of surface modification [30,31]. In the present study, we carried out chemical synthesis and characterization of PVP-functionalized magnetite (Fe 3 O 4 ) nanoparticles. Since the PVP was bonded to the surface of magnetite nanoparticles through covalent bonds, the prepared magnetic fluid (ferrofluid) was ve...

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“…Their high boiling points offer the advantages of operating on a large temperature interval (from 25 0 C up to the boiling point). The "core-shell" PVP (poly(vinylpyrrolidone))-nanoparticles can be obtained in one-pot polyol process by reduction of Fe(acac) 3 with 1,2-hexadecanediol in the presence of the PVP polymer surfactant in octyl ether (Liu et al, 2007). These particles are promising for biomedical applications like MRI agents and biosensors.…”

Section: Polyol Processmentioning

confidence: 99%

Tailored and Functionalized Magnetite Particles for Biomedical and Industrial Applications

Durdureanu-Angheluta¹,

Pinteală²,

Simionescu³

2012

Materials Science and Technology

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One-pot polyol synthesis of monosize PVP-coated sub-5nm Fe3O4 nanoparticles for biomedical applications

Cited by 122 publications

References 5 publications

Synthesis, characterization and antibacterial activity of superparamagnetic nanoparticles modified with glycol chitosan

Synthesis, characterization and antibacterial activity of superparamagnetic nanoparticles modified with glycol chitosan

Synthesis and characterization of PVP-functionalized superparamagnetic Fe3O4 nanoparticles as an MRI contrast agent

Tailored and Functionalized Magnetite Particles for Biomedical and Industrial Applications

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