Synthesis, characterization and antibacterial activity of superparamagnetic nanoparticles modified with glycol chitosan

Abstract

Iron oxide nanoparticles (IONPs) were synthesized by coprecipitation of iron salts in alkali media followed by coating with glycol chitosan (GC-coated IONPs). Both bare and GC-coated IONPs were subsequently characterized and evaluated for their antibacterial activity. Comparison of Fourier transform infrared spectra and thermogravimetric data of bare and GC-coated IONPs confirmed the presence of GC coating on IONPs. Magnetization curves showed that both bare and GC-coated IONPs are superparamagnetic and have saturation magnetizations of 70.3 and 59.8 emu g −1 , respectively. The IONP size was measured as ∼ 8-9 nm by transmission electron microscopy, and their crystal structure was assigned to magnetite from x-ray diffraction patterns. Both bare and GC-coated IONPs inhibited the growths of Escherichia coli ATCC 8739 and Salmonella enteritidis SE 01 bacteria better than the antibiotics linezolid and cefaclor, as evaluated by the agar dilution assay. GC-coated IONPs showed higher potency against E. coli O157:H7 and Staphylococcus aureus ATCC 10832 than bare IONPs. Given their biocompatibility and antibacterial properties, GC-coated IONPs are a potential nanomaterial for in vivo applications.

Highly efficient bacterial removal and disinfection by magnetic barium phosphate nanoflakes with embedded iron oxide nanoparticles

“…30 Moreover, iron oxide nanoparticles have been shown to generate ROS when interacting with bacteria, resulting in protein oxidation and cell death. 31,32 Additionally, E. coli cells were observed to be divided into two parts after being in contact with the sharp FBP edge (Fig. S18e and f †), demonstrating physical damage.…”

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Effect of Surface Charge and Hydrophobicity Modulation on the Antibacterial and Antibiofilm Potential of Magnetic Iron Nanoparticles

“…Hydrophilic negatively charged particles showed insignificant antibacterial activity, while modulation of surface functional group to impart a strong positive charge (e.g., ATPMS-MNPs; 24.5 mV) enhanced the antibacterial activity [8,54,55]. This indicated that surface positivity imparts antibacterial potential on the particles.…”