One-Pot Multiсomponent Synthesis and Characterization of Some New Pyrazolylpyrazoline Scaffolds as Antitubercular and Antimalarial Agents

Recent advances in the synthesis of new benzothiazole based anti-tubercular compounds

“…Substituted aldehydes 185a–b underwent multicomponent one pot reaction with 2-acetyl pyrrole or 2-acetyl-1,3-thiazole 186a–b in presence of sodium hydroxide in ethanol at room temperature under sonification to furnish desired pyrazolylpyrazoline derivatives 187a–d after getting cyclized with 1,3-benzothiazol-2-ylhydrazine 51a (Scheme 45, Table 36). 80…”

“…36). 80 Table 32 Anti-tubercular activity of synthesized coumarin dyes a Compounds R 100 mg mL −1 50 mg mL −1 25 mg mL −1 12.5 mg mL −1 6.25 mg mL −1 3.12 mg mL −1 1.6 mg mL −1 0. 37).…”

Synthesis, Characterization, Antitubercular Activity, and Molecular Docking Studies of Pyrazolylpyrazoline-Clubbed Triazole and Tetrazole Hybrids

“…In recent years, there has been endless interest in the exploration of novel pyrazole-clubbed pyrazoline moieties. A variety of modifications have been made to the pyrazole and pyrazoline moiety to boost its pharmacological effect because pyrazole–pyrazoline derivatives are widely studied for broad-spectrum biological activities. − The pyrazoline derivatives are widely used as anticancer, antibacterial, antifungal, antitubercular, antimalarial, anti-inflammatory, etc. The chemistry of triazole- and tetrazole-fused heterocyclic derivatives has gathered a lot of attention in recent years due to their synthetic and biological importance.…”