Recent advances in the synthesis of new benzothiazole based anti-tubercular compounds

Yadav, R.A.; Meena, Dilkhush; Singh, Kavita; Tyagi, Rajdeep; Yadav, Yogesh; Sagar, Rashmi

doi:10.1039/d3ra03862a

Cited by 5 publications

(2 citation statements)

References 81 publications

(94 reference statements)

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“…Benzo-thiazole (BT), a heterocyclic compound consists of a benzene nucleus connected to a five-membered ring that has N and S atoms in positions 1 and 3, respectively . BT is one of the most important groups of organic compounds of pharmacological importance because of its well-established biological and therapeutic effects.…”

Section: Introductionmentioning

confidence: 99%

“…7,15,16 Benzo-thiazole (BT), a heterocyclic compound consists of a benzene nucleus connected to a five-membered ring that has N and S atoms in positions 1 and 3, respectively. 17 BT is one of the most important groups of organic compounds of pharmacological importance because of its well-established biological and therapeutic effects. There has been an increase in interest in the creation of BT-based therapeutics in recent years due to the remarkable potential of BT as a therapeutic agent for several target disorders.…”

Section: ■ Introductionmentioning

confidence: 99%

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Assessment of the Inhibitory Efficacy of a Thiazole Derivative as an Efficient Corrosion Inhibitor for Augmenting the Resistance of MS in Acidic Environments

Assad,

Saha,

Kang

et al. 2024

Langmuir

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Numerous thiazole compounds have been developed as cutting-edge inhibitors because of a rising fascination with using corrosion inhibitors (CIs) and preventative measures to prevent mild steel (MS) from deteriorating. In this study, the ability of a novel thiazole derivative, 2hydrazono-3-methyl-2,3-dihydrobenzo[d]thiazole hydrochloride (HMDBT), to prevent corrosion of MS (MS) in HCl has been reconnoitered using various approaches, Viz. gravimetric analysis, electrochemical (EC) analysis, and different surface characterizations. With an inhibition efficiency (IE %) of 95.35%, the outcomes elucidate that HMDBT functions as a potent MS CI that is environmentally friendly and sustainable. The computed activation and thermodynamic factors were also employed to better explain the process underpinning the inhibiting tendency of HMDBT. According to the computed values, the HMDBT molecules physically and chemically adhered to the MS surface following the Langmuir model, generating a dense protective layer that may be associated with the presence of a benzene ring and heteroatoms (S & N) in the HMDBT architecture. Based on the findings of the EIS studies, an intensification in the CI's concentration from (50 →800) ppm is ushered by increases in polarization resistance (R p ) from (80.72, 354.31) Ω cm 2 , and attenuation in double-layer capacitance (C dl ) from (198.78 → 44.13) μF cm −2 , respectively, confirming the inhibitory proficiency of HMDBT. The IE of the inhibitor was reported around 95.35% by weight loss measurement and 89.94% through EC measurement. Theoretical analysis including density functional theory (DFT) and molecular dynamics (MD) simulations were carried out to investigate the additional effects of HMDBT on the anticorrosion effectiveness and mechanism of inhibition. The theoretical parameters that were calculated provided important assistance in comprehending the inhibitory mechanism that the CI's moieties disclosed and are in strong concord with experimental methods. To create a "green" inhibitor system, the work presented here provided a potent technique to reduce corrosion by adding a potent new inhibitor.

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Section: Introductionmentioning

confidence: 99%

Section: ■ Introductionmentioning

confidence: 99%

Assessment of the Inhibitory Efficacy of a Thiazole Derivative as an Efficient Corrosion Inhibitor for Augmenting the Resistance of MS in Acidic Environments

Assad,

Saha,

Kang

et al. 2024

Langmuir

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Synthesis, Properties, and Biological Applications of Benzothiazoles

Prashanth,

Gadewar,

Rao

et al. 2024

S-Heterocycles

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Benzothiazoles belong to the category of heterocyclic compounds that contain two heteroatoms: sulfur and nitrogen. They consist of a two-membered ring structure and are considered a low-basicity heterocyclic unit. Benzothiazole derivatives have found extensive applications in medicinal chemistry, agrochemicals, and materials science. This chapter offers a comprehensive examination of the synthesis and assessment of biological activity and characteristics of emerging benzothiazole derivatives. In the recent decade, benzothiazole-based compounds have garnered substantial interest owing to their wide range of biological activities and distinctive chemical attributes. This chapter delves into the most recent advancements in benzothiazole synthesis, their biological activities, and myriad properties that make them compelling prospects for drug development and materials science.

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Thiazoles

2024

S-Heterocycles

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Recent advances in the synthesis of new benzothiazole based anti-tubercular compounds

Abstract: This review highlights the recent synthetic developments of benzothiazole based anti-tubercular compounds. Structure activity relationship of benzothiazole derivatives with molecular docking studies of selected compounds have been discussed against the target DprE1.

Cited by 5 publications

References 81 publications

Assessment of the Inhibitory Efficacy of a Thiazole Derivative as an Efficient Corrosion Inhibitor for Augmenting the Resistance of MS in Acidic Environments

Assessment of the Inhibitory Efficacy of a Thiazole Derivative as an Efficient Corrosion Inhibitor for Augmenting the Resistance of MS in Acidic Environments

Synthesis, Properties, and Biological Applications of Benzothiazoles

Thiazoles

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