Abstract:The
BCR/ABLp210 fusion gene is a classic biomarker of
chronic myeloid leukemia, which can be divided into e13a2 and e14a2
isoforms according to different breakpoints. These two isoforms showed
distinct differences in clinical manifestation, treatment effect,
and prognosis risk. Herein, a strategy based on nanocluster beacon
(NCB) fluorescence was developed to identify the e13a2 and e14a2 isoforms
in one-pot. Because the fluorescence of AgNCs can be activated when
they are placed in proximity to the correspondi… Show more
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