One-pot growth of triangular SnS nanopyramids for photoacoustic imaging and photothermal ablation of tumors

Yang, Dongliang; Chen, Fei; He, Shili; Shen, Haifeng; Hu, Yanling; Feng, Na; Wang, Siyu; Weng, Lixing; Luo, Zhimin; Wang, Lianhui

doi:10.1039/c9nj03045j

Cited by 29 publications

(18 citation statements)

References 51 publications

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“…On the contrary, in the treatment group of NB/CuS@PCM NPs + laser, a remarkable deformation could be seen, which indicated that the tumor cells might undergo apoptosis or necrosis, confirming that the NB/CuS@PCM NPs possess a strong antitumor effect with the assistance of laser (Figure 5C). To observe apoptotic cells in tissue sections, the terminal transferase-mediated dUTP nick end-labeling (TUNEL) was carried out (Li et al, 2017;Wu et al, 2018;Yang et al, 2019). As expected, after the tumor was treated with NB/CuS@PCM NPs and laser, substantial tumor cells were labeled with green fluorescence (Figure 6).…”

Section: Resultsmentioning

confidence: 87%

An NIR-II Responsive Nanoplatform for Cancer Photothermal and Oxidative Stress Therapy

Huang

Han

et al. 2021

Front. Bioeng. Biotechnol.

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Chemodynamic therapy as an emerging therapeutic strategy has been implemented for oncotherapy. However, the reactive oxygen species can be counteracted by the exorbitant glutathione (GSH) produced by the tumor cells before exerting the antitumor effect. Herein, borneol (NB) serving as a monoterpenoid sensitizer, and copper sulfide (CuS NPs) as an NIR-II photothermal agent were loaded in a thermo-responsive vehicle (NB/CuS@PCM NPs). Under 1,060-nm laser irradiation, the hyperthermia produced by CuS NPs can be used for photothermal therapy and melt the phase change material for drug delivery. In the acidity microenvironment, the CuS NPs released from NB/CuS@PCM NPs could degrade to Cu2+, then Cu2+ was reduced to Cu+ during the depletion of GSH. As Fenton-like catalyst, the copper ion could convert hydrogen peroxide into hydroxyl radicals for chemodynamic therapy. Moreover, the NB originated from NB/CuS@PCM NPs could increase the intracellular ROS content to improve the treatment outcome of chemodynamic therapy. The animal experimental results indicated that the NB/CuS@PCM NPs could accumulate at the tumor site and exhibit an excellent antitumor effect. This work confirmed that the combination of oxidative stress–induced damage and photothermal therapy is a potential therapeutic strategy for cancer treatment.

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Section: Resultsmentioning

confidence: 87%

An NIR-II Responsive Nanoplatform for Cancer Photothermal and Oxidative Stress Therapy

Huang

Han

et al. 2021

Front. Bioeng. Biotechnol.

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“…OSCC is a highly malignant tumor type ( 18 ), and the development of effective methods to diagnose and treat OSCC represents an urgent task ( 19 ). Inflammation is a basic and important pathologic response of the body triggered by damage that can occur alone or accompany tumors ( 20 ).…”

Section: Discussionmentioning

confidence: 99%

The Ratio of Preoperative Serum Biomarkers Predicts Prognosis in Patients With Oral Squamous Cell Carcinoma

et al. 2021

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BackgroundDynamic changes in circulating immune-inflammatory cells have been regarded as simple and convenient prognostic biomarkers in various cancers. However, studies on the prognostic values of their ratios in oral squamous cell carcinoma (OSCC) remain limited.Materials and MethodsA total of 493 OSCC patients were included in the present study. Here, we investigated the prognostic values of the neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), neutrophil-to-white blood cell ratio (NWR), and lymphocyte-to-white blood cell ratio (LWR) in OSCC. The correlations of the NLR, LMR, NWR, and LWR with clinicopathological characteristics were statistically analyzed using the Chi-square test, Kaplan-Meier curves, and univariate and multivariate Cox regression models.ResultKaplan-Meier analyses revealed that OSCC patients with a high LMR and low NWR had prolonged overall survival (OS, P<0.001) and disease-free survival (DFS, P<0.001 and P=0.003, respectively), but there were no significant differences in metastasis-free survival (MFS, P=0.053 and P=0.052, respectively). In contrary, a high NLR and low LWR were associated with poor OS (P<0.001 and P=0.0016, respectively), DFS (P=0.0014 and 0.0012, respectively) and MFS (P=0.021 and 0.008, respectively). Additionally, Cox multivariate analyses showed that the LMR was an independent prognostic factor for both OS (P=0.007) and DFS (P=0.017), while the LWR was an independent prognostic factor for MFS (P=0.009).ConclusionPreoperative NLR, LMR, NWR, and LWR in the peripheral blood are significant prognostic factors for OSCC and might be helpful in predicting OSCC progression.

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“…PAI is a non-invasive biomedical imaging method that has the preponderances of rich optical contrast, deep tissue penetration, and high spatial resolution. [99][100][101] PAI has been extensively used in the diagnosis of cardiovascular disease, drug metabolism research, tumor imaging, etc. 39,56 Photoacoustic signal intensity is affected by the microenvironment, such as polarity, hypoxia, temperature, and pH.…”

Section: Photoacoustic Imaging (Pai)mentioning

confidence: 99%

Manganese oxide nanomaterials for bacterial infection detection and therapy

Qing

Liu

et al. 2022

J. Mater. Chem. B

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One-pot growth of triangular SnS nanopyramids for photoacoustic imaging and photothermal ablation of tumors

Abstract: Triangular SnS nanopyramids act as an efficient theranostic nanoagent for photoacoustic imaging and photothermal therapy.

Cited by 29 publications

References 51 publications

An NIR-II Responsive Nanoplatform for Cancer Photothermal and Oxidative Stress Therapy

An NIR-II Responsive Nanoplatform for Cancer Photothermal and Oxidative Stress Therapy

The Ratio of Preoperative Serum Biomarkers Predicts Prognosis in Patients With Oral Squamous Cell Carcinoma

Manganese oxide nanomaterials for bacterial infection detection and therapy

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