One-Pot Four Component Reaction for  the Synthesis of Formazans in an  Environmentally Benign Procedure  Mediated by KHSO&amp;lt;sub&amp;gt;4&amp;lt;/sub&amp;gt;

Das, Pranab Jyoti; Begum, Jesmin

doi:10.4236/gsc.2015.53016

Cited by 3 publications

(1 citation statement)

References 27 publications

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“…3 Formazans are characterized by π-π* transitions, and these transitions are sensitive to the nature of the substituents in the phenyl rings, the nature of organic solvents in solution, and the acidity and basicity of the medium. 4 Formazan derivatives have different pharmacological activities; therefore, a number of these compounds were synthesized through coupling reactions. 5 Formazan has a high biological activity, especially on cancer cells, due to the possession of the tetrazolium-formazan system produced by redox reactions.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of Formazan Derivatives from Schiff’s Base and Studying their Biological Activity

Kmal¹,

Behget²,

Husean³

2022

IJDDT

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A group of substituted formazine derivatives was prepared through several steps where the first step was the preparation of compound (1) by reacting chloroacetyl chloride with 2-aminopyrimidine, and the second step was the reaction of compound (1) with hydrazine hydrate to obtain the derivative (2) and in the third step was prepared Schiff’s base (3) by reaction of derivative (2) with para-dimethyl benzaldehyde and then a number of formazine derivatives were synthesized by reaction of derivative (3) with a number of substituted aromatic amines. The newly prepared derivatives are distinguished by their melting points (1H-nuclear magnetic resonance (1H-NMR), fourier transform infrared spectroscopy (FTIR)) spectra. The biological activity of the prepared derivatives was studied on two types of bacteria that cause urinary tract and measuring the diameter of the inhibition zone against the growth of these bacteria.

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Section: Introductionmentioning

confidence: 99%