One-pot fabrication of Hemin-N C composite with enhanced electrocatalysis and application to H2O2 sensing

Cao, Yue; Si, Weimeng; Hao, Qingli; Liu, Guohong; Lei, Wu; Xia, Xifeng; Li, Jiao; Wang, Fagang; Liu, Yuying

doi:10.1016/j.electacta.2017.12.111

Cited by 26 publications

(15 citation statements)

References 45 publications

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“…It is noteworthy that the Γ hemin value noticed in this work is the highest compared to the previous literature reports on the hemin-surface-confined system such as PGE@hemin (11 × 10 –10 mol cm –2 ), 15 MWCNT@hemin (27 × 10 –10 mol cm –2 ), 16 and N-doped GO@hemin (13 × 10 –10 mol cm –2 ). 39 In continuation, Nf polymer-coated GCE/Au nano –GMC@hemin (GCE/Au nano –GMC@hemin–Nf) was also examined for the redox activity (data not enclosed) ( Scheme 1 D). However, nil redox response was noticed, confirming the specificity of Chit for the axial coordination ET process.…”

Section: Results and Discussionmentioning

confidence: 99%

“…With an aim to improve the performance and literature reports based on molecular wiring systems, ,,,− Au nano particles were chosen as a wiring agent and incorporated in the optimal electrode as a GCE/Au nano –GMC@hemin–Chit configuration. The preparation procedure was optimized as casting a dilute solution of Au 3+ ion on the GCE as the first step followed by other modification procedures.…”

Section: Results and Discussionmentioning

confidence: 99%

“…The E o′ value (−320 mV) is matching with previous reports on hemin-modified electrodes, for example, hemin-MWCNT ( E o′ = −0.34 V vs Ag/AgCl), Au nano –GO–hemin ( E o′ = −0.4 V vs Ag/AgCl), and hemin-self-assembled gold monolayers via histidine and guanine quadruplex (G4) complexes ( E o′ = −0.22 to −0.3 V vs Ag/AgCl). , The calculated peak-to-peak separation value (Δ E p ) is 40 mV at v = 10 mV s –1 , indicating a fast ET process. It is noteworthy that the Γ hemin value noticed in this work is the highest compared to the previous literature reports on the hemin-surface-confined system such as PGE@hemin (11 × 10 –10 mol cm –2 ), MWCNT@hemin (27 × 10 –10 mol cm –2 ), and N-doped GO@hemin (13 × 10 –10 mol cm –2 ) . In continuation, Nf polymer-coated GCE/Au nano –GMC@hemin (GCE/Au nano –GMC@hemin–Nf) was also examined for the redox activity (data not enclosed) (Scheme D).…”

Section: Results and Discussionmentioning

confidence: 99%

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Axial Coordination Site-Turned Surface Confinement, Electron Transfer, and Bio-Electrocatalytic Applications of a Hemin Complex on Graphitic Carbon Nanomaterial-Modified Electrodes

et al. 2018

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Understanding the relation between the chemical bonding and the electron-transfer (ET) reaction of surface-confined hemin (a five-coordinated Fe-porphyrin-with-chlorine complex) is a special interest in the biomimicking studies of heme proteins. Owing to the difficulty in ET function, scanty electrochemical reports of hemin in aqueous solution were reported. It has been noticed that in most of the reported procedures, the sixth axial coordination position of the hemin complex has been unknowingly turned by attaching with water molecules (potential cycling in alkaline conditions or heating), solvents such as ethanol and dimethyl sulfoxide, and nitrogen-donating compounds that have helped for the heme ET reaction. In this work, a systematic effort has been taken to find out the contribution of hemin and its axial bond coordination with π–π interaction, hydrogen bonding, and hydrophobic binding systems toward the ET reaction. Various graphitic carbons such as graphitized mesoporous carbon (GMC), mesoporous carbon-hydrophilic and hydrophobic units, graphite nanopowder, graphene oxide, single-walled carbon, multiwalled carbon nanotube (MWCNT), and carboxylic acid-functionalized MWCNT (as a source for π–π interaction, hydrogen bonding, and hydrophobic environment) along with the amino functional group of chitosan (Chit; as an axial site coordinating system) have been tested by modifying them as a hemin hybrid on a glassy carbon electrode (GCE). In addition, a gold nanoparticle (Aunano) system was combined with the above matrix as a molecular wiring agent, and its role was examined. A highly stable and well-defined redox peak at an apparent formal potential (Eo′) of −320 mV versus Ag/AgCl with the highest surface excess of 120 × 10–10 mol cm–2 was noticed with the GCE/Aunano–GMC@hemin–Chit hybrid system, wherein all interactive features have been utilized. Omitting any of the individual interactions resulted in either decreased (with Aunano) or nil current response. As applications, efficient bio-electrocatalytic reduction and sensing of dissolved oxygen and hydrogen peroxide have been demonstrated.

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Section: Results and Discussionmentioning

confidence: 99%

Section: Results and Discussionmentioning

confidence: 99%

Section: Results and Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Axial Coordination Site-Turned Surface Confinement, Electron Transfer, and Bio-Electrocatalytic Applications of a Hemin Complex on Graphitic Carbon Nanomaterial-Modified Electrodes

et al. 2018

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“…To overcome these obstacles, non-enzymatic H 2 O 2 electrochemical sensors have been proposed in recent years replacing immobilized enzymes with various nanocomposites with peroxidase-like activity. These include noble metal nanocomposites [19,20,[23][24][25], metal oxide nanostructures [22,[26][27][28] and metalloporphyrins [28][29][30][31][32].…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, hemin has been extensively used to study the redox activity of heme-proteins. In addition, it exhibits remarkable good electrocatalysis towards some small molecules, such as O 2 [33], NO [34], NO 2 − [35], H 2 O 2 [28][29][30][31][32], trichloroacetic acid [36], organohalides [37], phenols [38] and artemisinin [39], many of them are related to biological processes. The hemin-Fe acts as the electroactive mediate in the electrocatalysis process.…”

Section: Introductionmentioning

confidence: 99%

Hemin-Modified SnO2/Metglas Electrodes for the Simultaneous Electrochemical and Magnetoelastic Sensing of H2O2

et al. 2018

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In this work, we present a simple and efficient method for the preparation of hemin-modified SnO2 films on Metglas ribbon substrates for the development of a sensitive magneto-electrochemical sensor for the determination of H2O2. The SnO2 films were prepared at low temperatures, using a simple hydrothermal method, compatible with the Metglas surface. The SnO2 film layer was fully characterized by X-ray Diffraction (XRD), Scanning Electron Microscopy (SEM), photoluminescence (PL) and Fourier Transform-Infrared spectroscopy (FT-IR). The properties of the films enable a high hemin loading to be achieved in a stable and functional way. The Hemin/SnO2-Metglas system was simultaneously used as a working electrode (WE) for cyclic voltammetry (CV) measurements and as a magnetoelastic sensor excited by external coils, which drive it to resonance and interrogate it. The CV scans reveal direct reduction and oxidation of the immobilized hemin, as well as good electrocatalytic response for the reduction of H2O2. In addition, the magnetoelastic resonance (MR) technique allows the detection of any mass change during the electroreduction of H2O2 by the immobilized hemin on the Metglas surface. The experimental results revealed a mass increase on the sensor during the redox reaction, which was calculated to be 767 ng/μM. This behavior was not detected during the control experiment, where only the NaH2PO4 solution was present. The following results also showed a sensitive electrochemical sensor response linearly proportional to the concentration of H2O2 in the range 1 × 10−6–72 × 10−6 M, with a correlation coefficient of 0.987 and detection limit of 1.6 × 10−7 M. Moreover, the Hemin/SnO2-Metglas displayed a rapid response (30 s) to H2O2 and exhibits good stability, reproducibility and selectivity.

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Versatile Construction of Biomimetic Nanosensors for Electrochemical Monitoring of Intracellular Glutathione

Chen

Jiao

et al. 2022

Angewandte Chemie

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The current strategies for nanoelectrode functionalization usually involve sophisticated modification procedures, uncontrollable and unstable modifier assembly, as well as a limited variety of modifiers. To address this issue, we propose a versatile strategy for large-scale synthesis of biomimetic molecular catalysts (BMCs) modified nanowires (NWs) to construct functionalized electrochemical nanosensors. This design protocol employs an easy, controllable and stable assembly of diverse BMCs-poly(3,4-ethylenedioxythiophene) (PEDOT) composites on conductive NWs. The intrinsic catalytic activity of BMCs combined with outstanding electron transfer ability of conductive polymer enables the nanosensors to sensitively and selectively detect various biomolecules. Further application of sulfonated cobalt phthalocyanine functionalized nanosensors achieves real-time electrochemical monitoring of intracellular glutathione levels and its redox homeostasis in single living cells for the first time.

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One-pot fabrication of Hemin-N C composite with enhanced electrocatalysis and application to H2O2 sensing

Cited by 26 publications

References 45 publications

Axial Coordination Site-Turned Surface Confinement, Electron Transfer, and Bio-Electrocatalytic Applications of a Hemin Complex on Graphitic Carbon Nanomaterial-Modified Electrodes

Axial Coordination Site-Turned Surface Confinement, Electron Transfer, and Bio-Electrocatalytic Applications of a Hemin Complex on Graphitic Carbon Nanomaterial-Modified Electrodes

Hemin-Modified SnO2/Metglas Electrodes for the Simultaneous Electrochemical and Magnetoelastic Sensing of H2O2

Versatile Construction of Biomimetic Nanosensors for Electrochemical Monitoring of Intracellular Glutathione

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