One-Pot Conversion of Aldoximes Into Nitriles via Aldoxime Tosylates Under Microwave Irradiation

Abstract

Silica-gel-supported aldoximes react with tosyl chloride at room temperature to give the corresponding aldoxime tosylates. These supported aldoxime tosylates were directly converted to their corresponding nitriles in high yields under microwave irradiation.

An Efficient One-Pot Synthesis of 5-(substituted amino)-1,2,4-thia- and -oxa-diazoles

“…The reaction between monosubstituted amidoximes 1a-k which were obtained according to the procedures described in the literature 1,2,43,[49][50][51][52][53][54][55][56] and N-substituted thioureas in the presence of KF/Al 2 O 3 in refluxing acetonitrile within 1-3 days afforded 3-substituted 5-anilino-(p-toluidino in the case of 2i and 2j) 1,2,4-thiadiazoles 2a-k (Scheme 1 and Table 1).…”

Potentiometric Study of Acid−Base Equilibria of 3,5-Disubstituted 1,2,4,5-Oxadiazaboroles in Nonaqueous Media

“…Aldehydes and nitriles were purchased from Merck and Fluka. Amidoximes and oxadiazaboroles were prepared according to literature procedures described previously. ,− 1 H and 13 C NMR spectra were recorded on Bruker and Varian spectrometers (300 and 400 MHz). IR spectra were recorded on a Jasco 430 FT/IR instrument (KBr pellet).…”