A general protocol for the synthesis of 5-(substituted amino)-1,2,4-thiadiazoles by the cyclocondensation reaction of amidoximes with N-substituted thioureas in the presence of KF/Al 2 O 3 , and of 5-(cyclohexylamino)-1,2,4-oxadiazoles with DCC in the presence of KF/Al 2 O 3 and thiourea, is described. The structures of the new compounds were elucidated by spectroscopic and physical data, and the crystal structure determination by X-ray diffraction of three examples.
Ring closure reactions O 0130An Efficient One-Pot Synthesis of 5-(Substituted amino)-1,2,4-thia-and oxa-diazoles. -A mechanism for the reaction with thiourea in the presence of DCC (IV) is proposed. -(DUERUEST*, Y.; YILDIRIM, M.; AYCAN, A.; J. Chem. Res. 2008, 4, 235-239; Dep. Chem., Abant Izzet Baysal Univ., TR-14280 Bolu, Turk.; Eng.) -H. Haber 41-029
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