One Percent Sodium Carboxymethylcellulose Prevents Experimentally Induced abdominal Adhesions in Horses

Hay, William P.; Mueller, P. O. E.; Harmon, B. G.; Amoroso, Lisa M.

doi:10.1053/jvet.2001.17849

Cited by 59 publications

(46 citation statements)

References 14 publications

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“…Several studies in the horse show evidence of the use CBMC reducing adhesion formation, with no adverse effects on anastomotic healing [124][125][126][127][128]. Several studies in the horse show evidence of the use CBMC reducing adhesion formation, with no adverse effects on anastomotic healing [124][125][126][127][128].…”

Section: Intestinal Manipulationmentioning

confidence: 99%

An update on equine post‐operative ileus: Definitions, pathophysiology and management

Lisowski

Pirie

Blikslager

et al. 2018

Equine Veterinary Journal

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Post-operative ileus (POI) is a serious condition which any horse undergoing abdominal surgery is at risk of developing, leading to increased hospitalisation time and resulting costs. Advances in the understanding of the development of equine POI are mainly based on human and rodent literature, where manipulation-induced inflammation has been identified as a trigger, with activation of resident muscularis externa macrophages playing a crucial role in the pathophysiology. Despite many pharmacological trials in all species, there is no single completely successful treatment for POI, highlighting that the condition is multifactorial in cause and requires a multimodal approach to minimise its incidence.

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Section: Intestinal Manipulationmentioning

confidence: 99%

An update on equine post‐operative ileus: Definitions, pathophysiology and management

Lisowski

Pirie

Blikslager

et al. 2018

Equine Veterinary Journal

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“…Intraoperative use of SCMC has been shown to decrease adhesion formation and improve survival rate following small intestinal surgery in horses [8,9]. As horses in which SCMC was used had significantly better short‐ and long‐term survival than horses not receiving SCMC, it appears that SCMC in this case series had a positive effect on survival probably by reducing adhesion formation.…”

Section: Discussionmentioning

confidence: 62%

“…Milking the impacted worms into the caecum often requires rather prolonged and aggressive handling of the small intestine. Serosal trauma by abrasion is an established model of intestinal adhesion formation and SCMC has been shown in this model to markedly decrease adhesions [9]. Using a lubricant such as SCMC subjectively decreases the serosal trauma during the procedure and may decrease the likelihood of adhesion formation.…”

Section: Discussionmentioning

confidence: 99%

Surgical treatment for acute small intestinal obstruction caused byParascaris equoruminfection in 15 horses (2002–2011)

Tatz¹,

Segev²,

Steinman³

et al. 2012

Equine Veterinary Journal

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SummaryReasons for performing study: There is a consensus in the veterinary literature that Parascaris equorum (ascarid) impaction carries a poor prognosis. Hence surgery is often delayed and foals are often subjected to euthanasia after diagnosis of ascarid impaction is established. Our clinical impression was that ascarid impaction carries a better prognosis than previously reported. Objectives: Our expectation was that manually evacuating the impaction into the caecum, thus refraining from opening the small intestine, would improve the prognosis for survival of horses with ascarid impaction. The aim of this study was to examine medical records of horses treated surgically for ascarid impaction, record their clinical findings and evaluate the association of outcome with the method of relieving the impaction. Methods: The medical records of all horses presented to our hospital between October 2002 and December 2011 that underwent exploratory celiotomy for ascarid impaction were reviewed. Information retrieved from the medical record included surgical findings, surgical technique, complications, shortand long-term survival. The association between categorical variables was assessed using the Fisher's exact test. A P value <0.05 was considered statistically significant. Results: Fifteen horses fulfilled the inclusion criteria. Eighty percent of horses (12/15) survived to discharge and 60% (6/10) survived for at least one year. Five horses are doing well but are still in convalescence. Horses that underwent small intestinal enterotomy or resection and anastomosis (n = 5) were less likely to survive to discharge (P = 0.022). Conclusions: In our study, manual evacuation of ascarid impaction into the caecum, while refraining from opening the small intestine resulted in significantly improved survival in horses with ascarid impaction. Potential relevance: Refraining from opening the small intestine may be the key to improving surgical outcome in horses with ascarid impaction.

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“…A evolução clínica dos animais de ambos os grupos mostrou-se satisfatória, dados que superam positivamente aos citados por Hay et al (2001), que utilizando outra metodologia de indução de aderências observaram desconforto abdominal em quatro de doze animais testados.…”

Section: Discussionunclassified

Avaliação cirúrgica e laboratorial da utilização de pericárdio homólogo em lesões por abrasão em serosa de cólon maior (flexura pélvica) de equinos

Leiria

Ogassawara

Salles

et al. 2015

Braz. J. Vet. Res. Anim. Sci.

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ResumoAderências intra-abdominais são complicações de cirurgias de equinos que podem resultar em processos obstrutivos e comprometer a sobrevida dos animais. O presente estudo utilizou dez equinos hígidos, machos, sem raça definida (SRD), com quatro a 15 anos de idade e peso vivo situado entre 300 e 400 quilogramas (kg). Os animais foram submetidos à laparotomia esquerda em estação com o objetivo de serem induzidas aderências, testar a utilização intestinal de membrana biológica de pericárdio como prevenção e avaliar as diferentes alterações sistêmicas e do líquido abdominal. Após sedação e analgesia local, foi utilizado o acesso cirúrgico em grade, na flexura pélvica foi criada uma área de abrasão que, no Grupo 1, foi coberta por pericárdio homólogo e no Grupo 2, lavada com solução fisiológica. Após reposicionamento foi realizada a sutura muscular, de subcutâneo e pele. O pós-operatório constou de avaliações clínicas, citologia do líquido abdominal, hematologia e bioquímica sérica nos momentos M0-pré-operatório e M7, M14, M21 e M28 dias de pós-operatório. Nova laparotomia foi realizada aos 30 dias para verificar aderências, aspecto e biópsia intestinal. A técnica cirúrgica possibilitou menor trauma e campo operatório restrito. A evolução clínica foi satisfatória e cicatriz fibrosa foi identificada entre os planos musculares. Aderências não foram observadas. As avaliações laboratoriais demonstraram aumento de bilirrubinas, hematócrito, monócito, ureia sanguíneos e de proteína, densidade e leucócitos segmentados no líquido peritoneal. Conclui-se que a abrasão foi insuficiente para promover aderências fibrosas. O implante, sem comprovada eficácia, é viável e possível, por não resultar em diferenças laboratoriais significativas ou alterações deletérias. Palavras-chave:Equinos. Pericárdio homólogo. Cólon maior. Aderências. AbstractIntra-abdominal adhesions are equine surgery complications, which can result in obstructive processes and jeopardize the survival of these animals. The present study used 10 healthy, male mongrel horses (SRD), with four and 15 years of age and weighing between 300 and 400 kilograms (kg), who underwent laparotomy left station with the aim of inducing adhesions, test intestinal membrane using pericardium as prevention and evaluating the different systemic changes and the abdominal fluid. After sedation and local anesthesia, the surgical approach was used in grade; pelvic flexure was created in an area of abrasion that in Group 1 was covered by homologous pericardium and in Group 2, washed with saline. After repositioning muscle, the skin and subcutaneous tissue were sutured. Postoperative care consisted of clinical evaluation, abdominal fluid cytology, hematology and serum biochemistry in moments M0-preoperative, and M7, M14, M21 and M28 days postoperatively. New laparotomy was performed at 30 days from the surgery to verify adhesion, appearance and intestinal biopsy. The surgical technique allowed less trauma and restricted operative field. The clinical course was satisfactory, and fibrous ...

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One Percent Sodium Carboxymethylcellulose Prevents Experimentally Induced abdominal Adhesions in Horses

Abstract: In horses at an increased risk for developing intraabdominal adhesions after intestinal surgery, the use of 1% SCMC during celiotomy may decrease the frequency of adhesion formation.

Cited by 59 publications

References 14 publications

An update on equine post‐operative ileus: Definitions, pathophysiology and management

An update on equine post‐operative ileus: Definitions, pathophysiology and management

Surgical treatment for acute small intestinal obstruction caused byParascaris equoruminfection in 15 horses (2002–2011)

Avaliação cirúrgica e laboratorial da utilização de pericárdio homólogo em lesões por abrasão em serosa de cólon maior (flexura pélvica) de equinos

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