One-Hour Postload Hyperglycemia Confers Higher Risk of Hepatic Steatosis to HbA1c-Defined Prediabetic Subjects

Fiorentino, Teresa Vanessa; Andreozzi, Francesco; Mannino, Gaia Chiara; Pedace, Elisabetta; Perticone, Maria; Sciacqua, Angela; Perticone, Francesco; Sesti, Giorgio

doi:10.1210/jc.2016-1856

Cited by 30 publications

(36 citation statements)

References 38 publications

(44 reference statements)

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“…The design of the CATAMERI study has been previously reported [14,[25][26][27]. The study cohorts include 2055 participants used to estimate the linear relationship between fasting plasma glucose and HbA1c in the study population to calculate the predicted HbA1c value, and 1120 individuals in whom hepatic steatosis was assessed by ultrasonography.…”

Section: Methodsmentioning

confidence: 99%

“…A growing body of evidence suggests that NAFLD is strongly associated not only with impaired glucose metabolism and obesity [5][6][7] but also with an increased risk to develop diabetes mellitus [8][9][10], and an independent association between NAFLD and glycated hemoglobin (HbA1c) levels has been reported in several studies [11][12][13][14]. HbA1c is the gold standard for evaluating glucose control in patients affected by diabetes mellitus and for monitoring the efficacy of therapies [15,16].…”

Section: Introductionmentioning

confidence: 99%

“…Nevertheless, no studies have been carried out to assess the correlation between HGI and NAFLD in subjects without type 2 diabetes. To address this issue, we sought to evaluate whether HGI is associated with hepatic steatosis and related biomarkers in a large cohort of adult White subjects participating to the CATAnzaro MEtabolic RIsk factors (CATAMERI) study [14,[25][26][27].…”

Section: Introductionmentioning

confidence: 99%

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Association between hemoglobin glycation index and hepatic steatosis in non-diabetic individuals

Fiorentino

Marini

Succurro

et al. 2017

Diabetes Research and Clinical Practice

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Hemoglobin glycation indexHepatic steatosis Non-enzymatic protein glycation A B S T R A C TAims: Hemoglobin glycation index (HGI), which is the difference between the observed value of HbA1 and the predicted HbA1c based on plasma glucose levels, represents a measure of the degree of non-enzymatic glycation of hemoglobin and it has been found to be positively associated with diabetic complications. Herein we investigated whether HGI is associated with hepatic steatosis and related biomarkers in subjects without diabetes.Methods: 1120 White individuals without diabetes were stratified in quartiles according to HGI levels. Hepatic steatosis was diagnosed by ultrasonography.Results: As compared with subjects in the lowest quartile of HGI those in the intermediate and high HGI groups displayed an unfavorable cardio-metabolic risk profile having significantly higher values of body mass index (BMI), waist circumference, % fat mass, total cholesterol, triglycerides, inflammatory markers such as high sensitivity C reactive protein, erythrocytes sedimentation rate, complement C3, platelets and white blood cell count, hepatic insulin resistance assessed by the liver IR index and lower concentrations of highdensity lipoprotein. HGI was positively associated with the biomarker of liver damage alanine aminotransferase, and fatty liver index, an indicator of hepatic steatosis. In a logistic regression analysis adjusted for age, gender and BMI individuals in the highest quartile of HGI exhibited a 1.6-fold increased odd of having hepatic steatosis (95% CI: 1.03-2.41; p = 0.03) as compared with subjects in the lowest quartile of HGI.Conclusions: Higher levels of HGI may identify subjects without diabetes at increased risk of having hepatic steatosis.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Association between hemoglobin glycation index and hepatic steatosis in non-diabetic individuals

Fiorentino

Marini

Succurro

et al. 2017

Diabetes Research and Clinical Practice

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“…We analyzed 1723 individuals consecutively recruited at the Department of Systems Medicine of the University of Rome-Tor Vergata and at the Department of Medical and Surgical Sciences of the University ''Magna Graecia'' of Catanzaro as previously described [30,[32][33][34][35][36][37][38].…”

Section: Methodsmentioning

confidence: 99%

“…Evidence has accrued suggesting that subjects with a 1-h plasma glucose concentration during an oral glucose tolerance test (OGTT) [155 mg/dl (8.6 mmol/l) are at increased risk of type 2 diabetes among those who have NGT [28][29][30][31]. Remarkably, subjects with 1-h postchallenge plasma glucose [155 mg/dl are characterized by a cluster of cardio-metabolic abnormalities such as insulin resistance [32], pro-atherogenic lipid profile [33], hepatic steatosis [34], carotid atherosclerosis [35], vascular stiffness [36], and left ventricular hypertrophy [37], and cardiac autonomic imbalance [38] which in turn have been inked to increased blood viscosity [1,3,[7][8][9][10][11]. The degree to which 1-h post-load plasma glucose [155 mg/dl is associated with blood viscosity remains unsettled.…”

Section: Introductionmentioning

confidence: 99%

Elevated 1-h post-challenge plasma glucose levels in subjects with normal glucose tolerance or impaired glucose tolerance are associated with whole blood viscosity

et al. 2017

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Aim It has been suggested that glucose levels C155 mg/dl at 1-h during an oral glucose tolerance test (OGTT) may predict development of type 2 diabetes and cardiovascular events among adults with normal glucose tolerance (NGT 1 h-high). Studies showed a link between increased blood viscosity and type 2 diabetes. However, whether blood viscosity is associated with dysglycemic conditions such as NGT 1 h-high, impaired glucose tolerance (IGT) or impaired fasting glucose (IFG) is unsettled. Methods 1723 non-diabetic adults underwent biochemical evaluation and OGTT. A validated formula based on hematocrit and total plasma proteins was employed to estimate whole blood viscosity. Subjects were categorized into NGT with 1 h glucose \155 mg/dL (NGT-1 h-low), NGT-1 h-high, IFG and/or IGT. Results Hematocrit and blood viscosity values appeared significantly higher in individuals with NGT 1 h-high, IFG and/or IGT as compared to NGT 1 h-low subjects. Blood viscosity was significantly correlated with age, waist circumference, blood pressure, HbA1c, fasting, 1-and 2-h post-challenge insulin levels, total cholesterol and lowdensity lipoprotein, triglycerides, fibrinogen, white blood cell, and inversely correlated with high-density lipoprotein and insulin sensitivity. Of the four glycemic parameters, 1-h post-challenge glucose showed the strongest correlation with blood viscosity (b = 0.158, P \ 0.0001) in a multivariate regression analysis model including several atherosclerosis risk factors. Conclusions Our results demonstrate a positive relationship between blood viscosity and 1-h post-challenge plasma glucose. They also suggest that a subgroup of NGT individuals with 1-h post-challenge plasma [155 mg/dl have increased blood viscosity comparable to that observed in subjects with IFG and/or IGT.

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Lessons learned from the 1‐hour post‐load glucose level during OGTT: Current screening recommendations for dysglycaemia should be revised

Bergman¹,

Jagannathan

Buysschaert

et al. 2018

Diabetes Metabolism Res

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This perspective covers a novel area of research describing the inadequacies of current approaches for diagnosing dysglycaemia and proposes that the 1-hour post-load glucose level during the 75-g oral glucose tolerance test may serve as a novel biomarker to detect dysglycaemia earlier than currently recommended screening criteria for glucose disorders. Considerable evidence suggests that a 1-hour post-load plasma glucose value ≥155 mg/dl (8.6 mmol/L) may identify individuals with reduced β-cell function prior to progressing to prediabetes and diabetes and is highly predictive of those likely to progress to diabetes more than the HbA or 2-hour post-load glucose values. An elevated 1-hour post-load glucose level was a better predictor of type 2 diabetes than isolated 2-hour post-load levels in Indian, Japanese, and Israeli and Nordic populations. Furthermore, epidemiological studies have shown that a 1-hour PG ≥155 mg/dl (8.6 mmol/L) predicted progression to diabetes as well as increased risk for microvascular disease and mortality when the 2-hour level was <140 mg/dl (7.8 mmol/L). The risk of myocardial infarction or fatal ischemic heart disease was also greater among subjects with elevated 1-hour glucose levels as were risks of retinopathy and peripheral vascular complications in a Swedish cohort. The authors believe that the considerable evidence base supports redefining current screening and diagnostic recommendations with the 1-hour post-load level. Measurement of the 1-hour PG level would increase the likelihood of identifying a larger, high-risk group with the additional practical advantage of potentially replacing the conventional 2-hour oral glucose tolerance test making it more acceptable in a clinical setting.

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One-Hour Postload Hyperglycemia Confers Higher Risk of Hepatic Steatosis to HbA1c-Defined Prediabetic Subjects

Abstract: These data suggest that a value of 1-hour postload glucose ≥155 mg/dL may be helpful to identify a subset of individuals within HbA1c-defined glycemic categories at higher risk of hepatic steatosis.

Cited by 30 publications

References 38 publications

Association between hemoglobin glycation index and hepatic steatosis in non-diabetic individuals

Association between hemoglobin glycation index and hepatic steatosis in non-diabetic individuals

Elevated 1-h post-challenge plasma glucose levels in subjects with normal glucose tolerance or impaired glucose tolerance are associated with whole blood viscosity

Lessons learned from the 1‐hour post‐load glucose level during OGTT: Current screening recommendations for dysglycaemia should be revised

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