Association between hemoglobin glycation index and hepatic steatosis in non-diabetic individuals

Abstract

Hemoglobin glycation indexHepatic steatosis Non-enzymatic protein glycation A B S T R A C TAims: Hemoglobin glycation index (HGI), which is the difference between the observed value of HbA1 and the predicted HbA1c based on plasma glucose levels, represents a measure of the degree of non-enzymatic glycation of hemoglobin and it has been found to be positively associated with diabetic complications. Herein we investigated whether HGI is associated with hepatic steatosis and related biomarkers in subjects without diabetes.Methods: 1120 White individuals without diabetes were stratified in quartiles according to HGI levels. Hepatic steatosis was diagnosed by ultrasonography.Results: As compared with subjects in the lowest quartile of HGI those in the intermediate and high HGI groups displayed an unfavorable cardio-metabolic risk profile having significantly higher values of body mass index (BMI), waist circumference, % fat mass, total cholesterol, triglycerides, inflammatory markers such as high sensitivity C reactive protein, erythrocytes sedimentation rate, complement C3, platelets and white blood cell count, hepatic insulin resistance assessed by the liver IR index and lower concentrations of highdensity lipoprotein. HGI was positively associated with the biomarker of liver damage alanine aminotransferase, and fatty liver index, an indicator of hepatic steatosis. In a logistic regression analysis adjusted for age, gender and BMI individuals in the highest quartile of HGI exhibited a 1.6-fold increased odd of having hepatic steatosis (95% CI: 1.03-2.41; p = 0.03) as compared with subjects in the lowest quartile of HGI.Conclusions: Higher levels of HGI may identify subjects without diabetes at increased risk of having hepatic steatosis.

The haemoglobin glycation index is associated with nonalcoholic fatty liver disease in healthy subjects

“…However, until now, only a single study has investigated the association between HGI and NAFLD. In this study of 1120 nondiabetic, white subjects, a high HGI was associated with a 1.6‐fold increase in the risk of hepatic steatosis after adjusting for age, sex and BMI . In agreement with these data, the current study showed that a high HGI was associated with a 1.56‐fold increased risk of NAFLD, after adjusting for factors such as TG, HDL‐C, alcohol intake, hsCRP, HOMA‐IR, AST, ALT and FPG, in addition to age, sex and BMI.…”

“…In this study of TA B L E 3 Risk of NAFLD by ultrasonography according to HGI quartile 1120 nondiabetic, white subjects, a high HGI was associated with a 1.6-fold increase in the risk of hepatic steatosis after adjusting for age, sex and BMI. 9 In agreement with these data, the current study showed that a high HGI was associated with a 1.56-fold increased risk of NAFLD, after adjusting for factors such as TG, HDL-C, alcohol intake, hsCRP, HOMA-IR, AST, ALT and FPG, in addition to age, sex and BMI. To the best of our knowledge, this is the first report to investigate the relationship between HGI and NAFLD in a nondiabetic Asian population.…”

“…The HGI reflects the difference between measured HbA1c and predicted HbA1c, which is calculated from mean blood glucose levels using a linear regression equation. Some studies suggest that higher HGI levels are associated with diabetic complications, metabolic disease and cardiovascular disease …”

“…associated with diabetic complications, metabolic disease and cardiovascular disease. [3][4][5][6][7][8][9] Nonalcoholic fatty liver disease (NAFLD) is one of the most prevalent metabolic diseases worldwide. 10 It can progress to steatohepatitis, cirrhosis and even hepatocellular carcinoma, which is associated with high mortality rates.…”

Association between Hemoglobin Glycation Index and NAFLD in Chinese Nondiabetic Individuals

“…To overcome these disadvantages, in 2002, Hempe et al developed a mathematical method which termed hemoglobin glycation index (HGI) to quantify the disparity between measured HbA1c and predicted HbA1c [15,16]. Nowadays, a few articles have been reported studying the relationship between HGI and nondiabetic individuals [17][18][19]. Obviously, HGI has been used to represent the nonenzymatic protein glycation, which is known to play a key role in the pathogenesis of NAFLD [20,21].…”