One Health: a multifaceted concept combining diverse approaches to prevent and control antimicrobial resistance

Guardabassi, Luca; Butaye, Patrick; Dockrell, David H.; Fitzgerald, J. Ross; Kuijper, Ed J.

doi:10.1016/j.cmi.2020.07.012

Cited by 32 publications

(23 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The complexity of this question lies in the fact that a thorough evaluation of the contribution of veterinary use of antimicrobial agents to AMR problems in human medicine requires a one-by-one analysis of the target resistant pathogens and antimicrobial agent, and requires comprehensive epidemiological, quantitative risk assessment and source attribution studies for each specific bug-drug combination. Recent research suggests that this impact might have been overestimated for certain resistant bacteria of high clinical relevance that are increasingly reported in animals, such as ESBL-producing E. coli [15,16]. Australian practitioners and veterinary students from Australia and South Africa perceived a moderate contribution of veterinary antimicrobial use to overall AMR problems, which was mostly attributed to intensive animal industries (despite most reports of multi-drug resistant pathogens in animals originating from companion animals) [3,4,6].…”

Section: Discussionmentioning

confidence: 99%

Towards a Better and Harmonized Education in Antimicrobial Stewardship in European Veterinary Curricula

et al. 2021

View full text Add to dashboard Cite

Education in antimicrobial stewardship (AMS) in veterinary medicine is essential to foster responsible antimicrobial use and control of antimicrobial resistance (AMR) in animals. AMS is listed by the EU and international organizations among the basic ‘Day One Competences’ required of veterinary students upon graduation. Our aim was to evaluate the quality of education of European veterinary students in AMS. We distributed a 27-item survey addressing the perceptions of preparedness and acquired skills on key topics related to AMS to final-year veterinary students in Europe. We collected 3423 complete answers from 89 veterinary schools in 30 countries. Selection of treatment strategies and awareness of emerging AMR problems were markedly different between countries. Overall, only one in four students was familiar with guidelines for antimicrobial use. The students perceived a medium-high impact of veterinary antimicrobial use on AMR in humans. Notably, 75% of the students felt the need for improved teaching on AMS, half of which also demanded more teaching on general antimicrobial therapy. Our results highlight several possible strategies to improve the quality of education, ranging from a better link between clinical rotations and the theory taught in pre-clinical modules, to a more effective introduction into best practices for antimicrobial use.

show abstract

Section: Discussionmentioning

confidence: 99%

Towards a Better and Harmonized Education in Antimicrobial Stewardship in European Veterinary Curricula

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Transmission chains for several closely related ESBL-E isolates were detected within the ICU over extended periods of time. K. pneumoniae ST307 bla CTX-M-15 was isolated for the first time from dog 4 on day 15 and thereafter from different hospitalized patients (dogs 6 and 8; cats 1, 4 and 5; days [22][23][24][25][26][27][28][29] and environmental surfaces (days 22 and 45, Figure 1), which indicates an ongoing transmission chain for this strain. Some of these isolates (dog 4, day 15; cat 5, day 29; environmental specimens, days 22 and 45) were characterized by whole genome sequencing (WGS) and core genome multi-locus sequence typing (cgMLST) analysis which revealed that all selected isolates belonged to the same cluster.…”

Section: Esbl-e In the Intensive Care Unitmentioning

confidence: 99%

“…The spread of ARM, such as extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-E), challenges human and veterinary healthcare settings worldwide and poses a public health threat [ 25 ]. In addition to their plasmid-mediated resistance to penicillins and cephalosporins, ESBL-E are often resistant to antibiotics such as fluoroquinolones, aminoglycosides, and sulfamethoxazole/trimethoprim [ 26 ].…”

Section: Introductionmentioning

confidence: 99%

Transmission Chains of Extended-Spectrum Beta-Lactamase-Producing Enterobacteriaceae at the Companion Animal Veterinary Clinic–Household Interface

et al. 2021

View full text Add to dashboard Cite

Extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-E) among animals and humans are a public health threat. This study analyzed the occurrence of ESBL-E in a high-risk environment in a companion animal clinic and two animal patients’ households. In an intensive care unit (ICU), rectal swabs from 74 dogs and cats, 74 hand swabs from staff and 298 swabs from surfaces were analyzed for ESBL-E. Seventeen hospitalized patients (23%) and ten (3%) surfaces in the ICU tested ESBL-E positive. Transmission chains for Klebsiella pneumoniae ST307 blaCTX-M-15 and Escherichia coli ST38 blaCTX-M-14, ST88 blaCTX-M-14 and ST224 blaCTX-M-1 were observed over extended periods of time (14 to 30 days) with similar strains isolated from patients and the clinical environment. After discharge, two colonized dogs (dogs 7 and 12) and their household contacts were resampled. Dog 7 tested repeatedly positive for 77 days, dog 12 tested negative; six (24%) surfaces in the household of the persistently colonized dog tested ESBL-E positive. The owner of dog 7 and one of the owners of dog 12 were colonized. Based on whole genome sequencing, isolates from the owners, their dogs and other ICU patients belonged to the same clusters, highlighting the public health importance of ESBL-E in companion animal clinics.

show abstract

“…However, the misuse of antimicrobials, leading to the emergence of antimicrobial resistance, residues in human food, and environmental pollution, has raised serious concerns worldwide [ 2 , 3 ]. The One Health concept offers a comprehensive approach to tackle this problem [ 4 ]. Measures have also been taken to restrict the use of antibiotics in veterinary medicine [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of Bacillus licheniformis and Bacillus subtilis on Gut Barrier Function, Proinflammatory Response, ROS Production and Pathogen Inhibition Properties in IPEC-J2—Escherichia coli/Salmonella Typhimurium Co-Culture

et al. 2022

View full text Add to dashboard Cite

The emergence of antimicrobial resistance raises serious concerns worldwide. Probiotics offer a promising alternative to enhance growth promotion in farm animals; however, their mode of action still needs to be elucidated. The IPEC-J2 cell line (porcine intestinal epithelial cells) is an appropriate tool to study the effect of probiotics on intestinal epithelial cells. In our experiments, IPEC-J2 cells were challenged by two gastrointestinal (GI) infection causing agents, Escherichia coli (E. coli) or Salmonella enterica ser. Typhimurium (S. Typhimurium). We focused on determining the effect of pre-, co-, and post-treatment with two probiotic candidates, Bacillus licheniformis or Bacillus subtilis, on the barrier function, proinflammatory cytokine (IL-6 and IL-8) response, and intracellular reactive oxygen species (ROS) production of IPEC-J2 cells, in addition to the adhesion inhibition effect. Bacillus licheniformis (B. licheniformis) and Bacillus subtilis (B. subtilis) proved to be anti-inflammatory and had an antioxidant effect under certain treatment combinations, and further effectively inhibited the adhesion of pathogenic bacteria. Interestingly, they had little effect on paracellular permeability. Based on our results, Bacillus licheniformis and Bacillus subtilis are both promising candidates to contribute to the beneficial effects of probiotic multispecies mixtures.

show abstract

One Health: a multifaceted concept combining diverse approaches to prevent and control antimicrobial resistance

Cited by 32 publications

References 9 publications

Towards a Better and Harmonized Education in Antimicrobial Stewardship in European Veterinary Curricula

Towards a Better and Harmonized Education in Antimicrobial Stewardship in European Veterinary Curricula

Transmission Chains of Extended-Spectrum Beta-Lactamase-Producing Enterobacteriaceae at the Companion Animal Veterinary Clinic–Household Interface

Effects of Bacillus licheniformis and Bacillus subtilis on Gut Barrier Function, Proinflammatory Response, ROS Production and Pathogen Inhibition Properties in IPEC-J2—Escherichia coli/Salmonella Typhimurium Co-Culture

Contact Info

Product

Resources

About