One-for-all phototheranostics: Single component AIE dots as multi-modality theranostic agent for fluorescence-photoacoustic imaging-guided synergistic cancer therapy

Wen, Haifei; Zhang, Zhijun; Kang, Miaomiao; Li, Haoxuan; Xu, Wenhan; Guo, Heng; Li, Youmei; Tan, Yonghong; Wen, Ziyao; Wu, Qian; Huang, Jiachang; Xi, Lei; Li, Kai; Wang, Lei; Wang, Dong; Tang, Ben Zhong

doi:10.1016/j.biomaterials.2021.120892

Cited by 68 publications

(51 citation statements)

References 37 publications

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“…The photothermal stability of TACQ (0.5 mM) was shown by negligible change after 10 on–off heating cycles by laser (635 nm, 600 mW cm –2 ; Figure C). The photothermal conversion efficiencies of TACQ and TACA were determined to be 55% and 67%, respectively (Figures D,E and S8), which are higher than most reported PTT agents. ,,− The distorted configuration of these AIEgens enlarged the intermolecular distance and loosened the molecular packing in the aggregate state benefiting to the intramolecular rotation needed to generate heat. The stronger push–pull interactions contribute to longer absorption wavelengths of TACQ and TACA, which cover the excitation wavelength (635 nm) better.…”

Section: Resultsmentioning

confidence: 86%

High-Performance Near-Infrared Aggregation-Induced Emission Luminogen with Mitophagy Regulating Capability for Multimodal Cancer Theranostics

Zhuang

Lü

et al. 2021

ACS Nano

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The construction of intelligent near-infrared (NIR) fluorophores for high specificity to cancer cells and application in multiple therapeutic modalities is crucial for precise cancer diagnostic and therapy. In this study, an aggregation-induced emission-active NIR fluorophore (TACQ) with mitophagy-modulating activity was synthesized and developed for mitochondrial targeting multimodal cancer theranostics. The strengthened push−pull interaction extended the emission of TACQ into the NIR-II region (>1000 nm). Further, the rotor structure and twisted molecular conformation enables nanoaggregates of TACQ to balance the radiative and nonradiative decays to simultaneously exhibit bright NIR emission, high photothermal conversion efficiency (55%), and efficient generation of reactive oxygen species. The lipocationic property of TACQ allows it to selectively accumulate in the mitochondria of cancer cells. TACQ can induce mitophagy and block mitophagic flux facilitating cancer cell apoptosis. Both in vitro and in vivo evaluations revealed that TACQ is an efficient theranostic agent for NIR fluorescence and photothermal imaging-guided synergistic chemo-photothermal and photodynamic therapy.

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Section: Resultsmentioning

confidence: 86%

High-Performance Near-Infrared Aggregation-Induced Emission Luminogen with Mitophagy Regulating Capability for Multimodal Cancer Theranostics

Zhuang

Lü

et al. 2021

ACS Nano

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“…In this regard, a series of structurally twisted and charged AIEgens were reported for high-performance multimodal theranostic applications in the form of single-component AIE dots. [291][292][293][294][295][296] As a representative example, three positively charged AIE compounds named TAM, TSAM and TSSAM were prepared (Fig. 25g).…”

Section: Balancing the Excited-state Energy Dissipations Of Aiegensmentioning

confidence: 99%

The fast-growing field of photo-driven theranostics based on aggregation-induced emission

et al. 2022

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“…In the presence of TSSAM NPs and laser irradiation, all tumors were eradicated on day 3. Later, Wen et al [ 85 ] also designed four novel NIR-emissive AIEgens. Benefiting from the highly bright emission of the tail located in the NIR-II region in the aggregated state, photothermal conversion efficiency, and high ROS generation capability of TTT-4, in vivo multimodal imaging and therapy performance of TTT-4 dots was evaluated.…”

Section: Multimodal Imaging-guided Synergistic Therapymentioning

confidence: 99%

NIR-II Aggregation-Induced Emission Luminogens for Tumor Phototheranostics

Tan

Liu

et al. 2022

Biosensors

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As an emerging and powerful material, aggregation-induced emission luminogens (AIEgens), which could simultaneously provide a precise diagnosis and efficient therapeutics, have exhibited significant superiorities in the field of phototheranostics. Of particular interest is phototheranostics based on AIEgens with the emission in the range of second near-infrared (NIR-II) range (1000–1700 nm), which has promoted the feasibility of their clinical applications by virtue of numerous preponderances benefiting from the extremely long wavelength. In this minireview, we summarize the latest advances in the field of phototheranostics based on NIR-II AIEgens during the past 3 years, including the strategies of constructing NIR-II AIEgens and their applications in different theranostic modalities (FLI-guided PTT, PAI-guided PTT, and multimodal imaging-guided PDT–PTT synergistic therapy); in addition, a brief conclusion of perspectives and challenges in the field of phototheranostics is given at the end.

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One-for-all phototheranostics: Single component AIE dots as multi-modality theranostic agent for fluorescence-photoacoustic imaging-guided synergistic cancer therapy

Cited by 68 publications

References 37 publications

High-Performance Near-Infrared Aggregation-Induced Emission Luminogen with Mitophagy Regulating Capability for Multimodal Cancer Theranostics

High-Performance Near-Infrared Aggregation-Induced Emission Luminogen with Mitophagy Regulating Capability for Multimodal Cancer Theranostics

The fast-growing field of photo-driven theranostics based on aggregation-induced emission

NIR-II Aggregation-Induced Emission Luminogens for Tumor Phototheranostics

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