One-dimensional and two-dimensional NMR spectroscopy of sterols

Goad, L. John; Akihisa, Toshihiro

doi:10.1007/978-94-009-1447-6_10

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2015

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“…The full assignments of the structures of compounds 1-3 were deduced from full correlation analysis of its COSY, HMBC, HSQC spectra and confirmed by comparing their data with published ones. [ 7 8 9 10 11 12 13 14 15 16 ] All isolated compounds were tested in vitro for their cytotoxic activity against human cervical adenocarcinoma cell line (Hela), Compound 1 is the best one among the tested compounds having low IC 50 value 9.25 μg/ml together with low resistant fraction 13% compared to the other tested compounds 2 and 3 which encountered high resistance fraction of about 48 and 45%, respectively [ Figure 2 ]. The result was in accordance with previous reports concerning the cytotoxic activity of euphol (1).…”

Section: Resultsmentioning

confidence: 99%