One-day acceptance and commitment therapy (ACT) workshop improves anxiety but not vascular function or inflammation in adults with moderate to high anxiety levels in a randomized controlled trial

Fiedorowicz, Jess G.; Dindo, Lilian; Ajibewa, Tiwaloluwa A.; Persons, Jane E.; Marchman, James N.; Holwerda, Seth W.; Abosi, Oluchi; DuBose, Lyndsey E.; Wooldridge, Nealy A; Myers, Janie; Stroud, Amy; Dubishar, Kaitlyn; Liu, Zhuangzhuang; Pierce, Gary L.

doi:10.1016/j.genhosppsych.2021.09.009

Cited by 4 publications

(1 citation statement)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Future research should investigate for whom an ACT-based mHealth intervention is most helpful and perhaps examine a stepped care model, wherein the mHealth intervention is followed by an increased level of care for those who remain in need. The findings align with prior work, indicating that ACT is impactful in brief intervals [ 38 , 39 , 41 , 42 ], via internet-delivered interventions [ 32 - 38 ], via mobile app [ 28 , 29 , 40 ], and with college students [ 36 , 38 , 59 ].…”

Section: Discussionsupporting

confidence: 86%

Mobile Acceptance and Commitment Therapy With Distressed First-Generation College Students: Microrandomized Trial

Kroska¹,

Gruichich²,

Maronge³

et al. 2023

JMIR Ment Health

View full text Add to dashboard Cite

Background Extant gaps in mental health services are intensified among first-generation college students. Improving access to empirically based interventions is critical, and mobile health (mHealth) interventions are growing in support. Acceptance and commitment therapy (ACT) is an empirically supported intervention that has been applied to college students, via mobile app, and in brief intervals. Objective This study evaluated the safety, feasibility, and effectiveness of an ACT-based mHealth intervention using a microrandomized trial (MRT) design. Methods Participants (N=34) were 18- to 19-year-old first-generation college students reporting distress, who participated in a 6-week intervention period of twice-daily assessments and randomization to intervention. Participants logged symptoms, moods, and behaviors on the mobile app Lorevimo. After the assessment, participants were randomized to an ACT-based intervention or no intervention. Analyses examined proximal change after randomization using a weighted and centered least squares approach. Outcomes included values-based and avoidance behavior, as well as depressive symptoms and perceived stress. Results The findings indicated the intervention was safe and feasible. The intervention increased values-based behavior but did not decrease avoidance behavior. The intervention reduced depressive symptoms but not perceived stress. Conclusions An MRT of an mHealth ACT-based intervention among distressed first-generation college students suggests that a larger MRT is warranted. Future investigations may tailor interventions to contexts where intervention is most impactful. Trial Registration ClinicalTrials.gov NCT04081662; https://clinicaltrials.gov/show/NCT04081662 International Registered Report Identifier (IRRID) RR2-10.2196/17086

show abstract

Section: Discussionsupporting

confidence: 86%

Mobile Acceptance and Commitment Therapy With Distressed First-Generation College Students: Microrandomized Trial

Kroska¹,

Gruichich²,

Maronge³

et al. 2023

JMIR Ment Health

View full text Add to dashboard Cite

show abstract

Comparative efficacy of psychological interventions on immune biomarkers: A systematic review and network meta-analysis (NMA)

Ballesio

Zagaria

Vacca

et al. 2023

Brain, Behavior, and Immunity

View full text Add to dashboard Cite

Translational Research of the Acute Effects of Negative Emotions on Vascular Endothelial Health: Findings From a Randomized Controlled Study

Shimbo,

Cohen,

McGoldrick

et al. 2024

JAHA

View full text Add to dashboard Cite

Background Provoked anger is associated with an increased risk of cardiovascular disease events. The underlying mechanism linking provoked anger as well as other core negative emotions including anxiety and sadness to cardiovascular disease remain unknown. The study objective was to examine the acute effects of provoked anger, and secondarily, anxiety and sadness on endothelial cell health. Methods and Results Apparently healthy adult participants (n=280) were randomized to an 8‐minute anger recall task, a depressed mood recall task, an anxiety recall task, or an emotionally neutral condition. Pre−/post‐assessments of endothelial health including endothelium‐dependent vasodilation (reactive hyperemia index), circulating endothelial cell‐derived microparticles (CD62E+, CD31+/CD42−, and CD31+/Annexin V+) and circulating bone marrow‐derived endothelial progenitor cells (CD34+/CD133+/kinase insert domain receptor+ endothelial progenitor cells and CD34+/kinase insert domain receptor+ endothelial progenitor cells) were measured. There was a group×time interaction for the anger versus neutral condition on the change in reactive hyperemia index score from baseline to 40 minutes ( P =0.007) with a mean±SD change in reactive hyperemia index score of 0.20±0.67 and 0.50±0.60 in the anger and neutral conditions, respectively. For the change in reactive hyperemia index score, the anxiety versus neutral condition group by time interaction approached but did not reach statistical significance ( P =0.054), and the sadness versus neutral condition group by time interaction was not statistically significant ( P =0.160). There were no consistent statistically significant group×time interactions for the anger, anxiety, and sadness versus neutral condition on endothelial cell‐derived microparticles and endothelial progenitor cells from baseline to 40 minutes. Conclusions In this randomized controlled experimental study, a brief provocation of anger adversely affected endothelial cell health by impairing endothelium‐dependent vasodilation.

show abstract

One-day acceptance and commitment therapy (ACT) workshop improves anxiety but not vascular function or inflammation in adults with moderate to high anxiety levels in a randomized controlled trial

Cited by 4 publications

References 44 publications

Mobile Acceptance and Commitment Therapy With Distressed First-Generation College Students: Microrandomized Trial

Mobile Acceptance and Commitment Therapy With Distressed First-Generation College Students: Microrandomized Trial

Comparative efficacy of psychological interventions on immune biomarkers: A systematic review and network meta-analysis (NMA)

Translational Research of the Acute Effects of Negative Emotions on Vascular Endothelial Health: Findings From a Randomized Controlled Study

Contact Info

Product

Resources

About