Comparative efficacy of psychological interventions on immune biomarkers: A systematic review and network meta-analysis (NMA)

Do interventions for mood improve inflammatory biomarkers in inflammatory bowel disease?: a systematic review and meta-analysis

“…Our findings corroborate meta-analyses across long-term conditions showing enhanced immune function following psychosocial interventions, 10 , 11 but add that reduced inflammation can occur specifically in IBD populations. Additional inflammatory benefit was seen in psychological therapy interventions and interventions with larger effects on mood.…”

“…Meta-analyses of randomised controlled trials (RCTs) across different medical conditions demonstrated that psychosocial interventions reduced inflammation and levels of proinflammatory cytokines by 18–48%, when compared with controls. 10 , 11 Exact mechanisms are not fully understood, but interventions which reduce negative psychological factors appear to subsequently impact immune system function and inflammation, partly through activation of the parasympathetic nervous system. 12 , 13 , 14 This may be relevant for IBD, as psychological and behavioural factors are likely to impact intestinal inflammation and disease activity through the gut-brain axis.…”

Inflammatory biomarkers and psychological variables to assess quality of life in patients with inflammatory bowel disease: a cross-sectional study

“…Indeed, therapies aimed at ameliorating anxiety or depression processes in these patients, evaluated using HADS-A and HADS-D, improved QoL perceptions and mean QoL index scores [ 36 ]. Moreover, a meta-analysis across various medical conditions demonstrated that psychosocial interventions reduced inflammation and proinflammatory cytokine levels by 18–48% compared to controls [ 37 ]. The precise mechanisms underlying this phenomenon remain incompletely understood, but interventions targeting negative psychological factors appear to influence immune system function and inflammation, partly through activation of the parasympathetic nervous system [ 38 , 39 ].…”

Inflammatory hypotheses of sleep disturbance - depression link: Update and research agenda

“…For instance, anti-TNF and anti-IL-6 therapies were associated with improvements in depressive symptoms, including subjective sleep disturbance in autoimmune diseases (e.g., Fonseka et al, 2015 ; Karatas et al, 2018 ; Siebenhüner et al, 2021 ). Specularly, some experimental studies showed that psychotherapy interventions targeting depression symptoms such as cognitive behavioural therapy (CBT) and mindfulness may indirectly and moderately reduce pro-inflammatory markers such as CRP, IL-6 and IL-8 in individuals with major depression (e.g., Euteneuer et al, 2017 ; Memon et al, 2017 ; Ballesio et al 2023 ).…”