Do interventions for mood improve inflammatory biomarkers in inflammatory bowel disease?: a systematic review and meta-analysis

Seaton, Natasha; Hudson, Joanna; Harding, Sophie; Norton, Sam; Mondelli, Valeria; Jones, Annie S.K.; Moss-Morris, Rona

doi:10.1016/j.ebiom.2023.104910

Cited by 3 publications

(1 citation statement)

References 60 publications

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“…who conducted a prospective longitudinal follow-up study with 414 IBD patients and found that IBD patients with abnormal anxiety sub-scores had poorer IBD-related outcomes compared to those without elevated anxiety sub-scores [ 41 ]. Additionally, a recent meta-analysis involving 28 RCTs and 1789 participants with IBD concluded that treatments addressing mood outcomes, such as anxiety, have beneficial effects on both generic inflammation and disease-specific biomarkers, such as fecal calprotectin [ 42 ]. Moreover, psychological interventions demonstrated larger treatment effects on mood compared to exercise or antidepressants.…”

Section: Discussionmentioning

confidence: 99%

Inflammatory biomarkers and psychological variables to assess quality of life in patients with inflammatory bowel disease: a cross-sectional study

González-Moret,

Cebolla-Martí,

Almodóvar-Fernández

et al. 2024

Annals of Medicine

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Background Inflammatory bowel disease (IBD) is a chronic gastrointestinal condition. While inflammatory biomarkers are valuable for diagnosing and monitoring the disease, their correlation with patients’ quality of life (QoL) is not well-established. Purpose This study aims to investigate the correlations between inflammatory biomarkers and the quality of life (QoL) variables of individuals diagnosed with IBD in clinical remission. Methods The sample of this cross-sectional study included 74 patients (80% women; 45 ± 11 years old) diagnosed with IBD. Outcome variables included faecal calprotectin (FC), C-reactive protein (CRP), cortisol levels from hair samples, and anxiety and depression assessed using the Hospital Anxiety and Depression Scale (HADS-A and HADS-D, respectively), alongside QoL evaluated with the Inflammatory Bowel Disease Questionnaire 32 (IBDQ-32). Bivariate correlations were calculated using the Pearson correlation coefficient, and stepwise linear regression analyses were conducted to identify independent factors contributing to IBDQ-32 scores. Results The IBDQ-32 did not significantly correlate with any biomarkers. However, it exhibited a large and statistically significant negative correlation with HADS-A (r = −0.651) and HADS-D (r = −0.611) scores ( p < 0.001). Stepwise linear regression analyses indicated that HADS-A was a significant and independent predictor for IBDQ-32 scores (Adjusted R 2 = 0.41, β = −0.65, p < 0.001). Conclusions Inflammatory markers such as CRP, FC, or cortisol in hair do not play a decisive role in assessing the QoL of IBD patients. These findings emphasize the significance of considering psychological factors in evaluating and managing QoL in IBD patients in order to identify severity, suggesting that instruments like HADS should be integral to comprehensive patient assessments.

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Section: Discussionmentioning

confidence: 99%

Inflammatory biomarkers and psychological variables to assess quality of life in patients with inflammatory bowel disease: a cross-sectional study

González-Moret,

Cebolla-Martí,

Almodóvar-Fernández

et al. 2024

Annals of Medicine

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Yoga in Pediatric Gastroenterology

Peropat,

Abbas,

Perez

et al. 2024

Curr Gastroenterol Rep

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Purpose of Review Pediatric use of yoga as an integrative medicine modality has increased in prevalence over the last several decades. In this article, we review the available evidence for yoga in pediatric gastrointestinal disorders. Recent Findings Evidence supports that in many pediatric disorders of gut brain interaction (DGBI), including irritable bowel syndrome, functional abdominal pain and functional dyspepsia, yoga decreases pain intensity and frequency and increases school attendance. Yoga has been shown to improve health-related quality of life and improve stress management as an effective adjunct to standard medical therapy in pediatric inflammatory bowel disease (IBD). Further studies are needed regarding optimal frequency, duration of practice and evaluation of the impact on IBD disease activity measures. Summary Yoga may benefit pediatric gastroenterology patients with DGBIs and IBD through improving quality of life and reducing pain. Future yoga studies could investigate biomarkers and continued research will help integrate this modality into routine pediatric gastroenterology care.

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Advances in the Study of the Gut-Brain Axis in Ulcerative Colitis

艾

2024

ACM

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Do interventions for mood improve inflammatory biomarkers in inflammatory bowel disease?: a systematic review and meta-analysis

Cited by 3 publications

References 60 publications

Inflammatory biomarkers and psychological variables to assess quality of life in patients with inflammatory bowel disease: a cross-sectional study

Inflammatory biomarkers and psychological variables to assess quality of life in patients with inflammatory bowel disease: a cross-sectional study

Yoga in Pediatric Gastroenterology

Advances in the Study of the Gut-Brain Axis in Ulcerative Colitis

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