One century of healing currents into the brain from the scalp: From electroconvulsive therapy to repetitive transcranial magnetic stimulation for neuropsychiatric disorders

Iorio, Riccardo Di; Rossi, Símone; Rossini, Paolo Maria

doi:10.1016/j.clinph.2021.10.014

Cited by 9 publications

(8 citation statements)

References 108 publications

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“…Women who are breastfeeding may be concerned that their infant will be exposed to psychotropic medications, and worried about the long-term developmental effects of this exposure ( 5 ). Electroconvulsive therapy is strongly recommended for the treatment of major depression, but is associated with acute adverse effects such as memory disorder and headaches ( 6 ). As such, there is an urgent need for new therapies for PPD that have minimal side effects and can be used over long durations.…”

Section: Introductionmentioning

confidence: 99%

Improved Interhemispheric Functional Connectivity in Postpartum Depression Disorder: Associations With Individual Target-Transcranial Magnetic Stimulation Treatment Effects

Zhang

Mu²,

et al. 2022

Front. Psychiatry

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Postpartum depression (PPD) is a depressive condition that is associated with a high risk of stressful life events, poor marital relationships, and even suicide. Neuroimaging techniques have enriched our understanding of cerebral mechanisms underlying PPD; namely, abnormalities in the amygdala-insula-frontal circuit might contribute to the pathogenesis of PPD. Stanford Accelerated Intelligent Neuromodulation Therapy (SAINT) is a recently validated neuroscience-informed accelerated intermittent theta-burst stimulation repetitive transcranial magnetic stimulation (rTMS) protocol. It has been shown to be effective, safe, tolerable, and rapid acting for treating treatment-resistant depression, and may be a valuable tool in the treatment of PPD. The purpose of the current study was to detect inter-hemispheric connectivity changes and their relationship with the clinical treatment effects of rTMS. Resting-state fMRI data from 32 patients with PPD treated with SAINT were collected and compared with findings from 32 age matched healthy controls. Voxel-mirrored homotopic connectivity (VMHC) was used to analyze the patterns of interhemispheric intrinsic functional connectivity in patients with PPD. Scores on the 17-item Hamilton Depression Rating Scale, Edinburgh Postnatal Depression Scale (EPDS) scores, and the relationships between these clinical characteristics and VMHC were the primary outcomes. Patients with PPD at baseline showed reduced VMHC in the amygdala, insula, and medial frontal gyrus compared with the HCs. These properties showed a renormalization after individualized rTMS treatment. Furthermore, increased connectivity between the left and right insula after SAINT was significantly correlated with the improvement of EPDS scores. Our results reveal the disruptions in the intrinsic functional architecture of interhemispheric communication in patients with PPD, and provide evidence for the pathophysiological mechanisms and the effects of rTMS.

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Section: Introductionmentioning

confidence: 99%

Improved Interhemispheric Functional Connectivity in Postpartum Depression Disorder: Associations With Individual Target-Transcranial Magnetic Stimulation Treatment Effects

Zhang

Mu²,

et al. 2022

Front. Psychiatry

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“…En el Perú la carencia de formación profesional específica en TEC, también puede haber influido en la disminución del uso de la TEC [8], ya que requiere de un equipo profesional familiarizado y capacitado en esta área, donde la enfermera tiene un papel profesional muy importante en los cuidados antes durante y después del tratamiento al paciente mostrado en la TABLA 1. (EMTr) como un tratamiento eficaz, no invasivo, s eguro e indoloro para los pacientes con depresión que no han respondido al menos a un antidepresivo [10]. La idea de aplicar EMTr en el tratamiento de la depresión se basó en los resultados de estudios neurofisiológicos y de neuroimagen previos que habían revelado anomalías estructurales y funcionales en redes y regiones cerebrales ampliamente distribuidas, incluidas la corteza cingulada anterior y el sistema límbico [10].…”

Section: Introductionunclassified

“…(EMTr) como un tratamiento eficaz, no invasivo, s eguro e indoloro para los pacientes con depresión que no han respondido al menos a un antidepresivo [10]. La idea de aplicar EMTr en el tratamiento de la depresión se basó en los resultados de estudios neurofisiológicos y de neuroimagen previos que habían revelado anomalías estructurales y funcionales en redes y regiones cerebrales ampliamente distribuidas, incluidas la corteza cingulada anterior y el sistema límbico [10]. La Terapia Electroconvulsiva (TEC) y la Estimulación Magnética Transcraneal repetitiva (EMTr) han tomado fuerza en la investigación clínica.…”

Section: Introductionunclassified

Transcranial magnetic stimulation as an optional technique to electroconvulsive therapy in Peru

Foronda¹,

Nieves-Barreto²,

Arriola³

et al. 2022

Proceedings of the 20th LACCEI International Multi-Conference for Engineering, Education and Technology: “Education, Research A

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Repetitive transcranial magnetic stimulation (rTMS) is a novel, non-invasive technique that uses electromagnetic force to alter neuronal excitability. The objective of this work is to carry out a brief but updated review of the basic principles of rTMS and to compare it with the principles of electroconvulsive therapy (ECT) in order to analyze its use and usefulness as an alternative method to ECT in Peru.

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“…For instance, such maps could be used to define targets for rehabilitation and cognitive enhancement purposes using transcranial magnetic stimulation (TMS) and transcranial electrical stimulation (tES), the two techniques able to modulate one or more brain region with an excellent spatial resolution and minimal side effects. [27][28][29][30][31][32] Considering the relevance of WM to high cognitive functions, its enhancement could also resonate in other cognitive domains, such as inhibition, flexibility, and fluid intelligence, and improve patients' quality of life.…”

mentioning

confidence: 99%

“…Additionally, we investigated the qualitative overlap, thus without any statistical comparison, between these activation maps and the previously published ALE maps in healthy patients, 18 underlying similarities and differences between pathological and healthy brains in the WM domain, and suggesting possible targets for future noninvasive brain stimulation (NIBS) studies. For instance, such maps could be used to define targets for rehabilitation and cognitive enhancement purposes using transcranial magnetic stimulation (TMS) and transcranial electrical stimulation (tES), the two techniques able to modulate one or more brain region with an excellent spatial resolution and minimal side effects 27–32 . Considering the relevance of WM to high cognitive functions, its enhancement could also resonate in other cognitive domains, such as inhibition, flexibility, and fluid intelligence, and improve patients' quality of life.…”

mentioning

confidence: 99%

Neural correlates of N‐back task performance and proposal for corresponding neuromodulation targets in psychiatric and neurodevelopmental disorders

Mencarelli

Romanella

Lorenzo

et al. 2022

Psychiatry Clin Neurosci

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Aim: Working memory (WM) deficit represents the most common cognitive impairment in psychiatric and neurodevelopmental disorders, making the identification of its neural substrates a crucial step towards the conceptualization of restorative interventions. We present a meta-analysis focusing on neural activations associated with the most commonly used task to measure WM, the N-back task, in patients with schizophrenia, depressive disorder, bipolar disorder, and attentiondeficit/hyperactivity disorder. Showing qualitative similarities and differences in WM processing between patients and healthy controls, we propose possible targets for cognitive enhancement approaches.Methods: Selected studies, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, were analyzed through the activation likelihood estimate statistical framework, with subsequent generation of disorder-specific N-back activation maps.Results: Despite similar WM deficits shared across all disorders, results highlighted different brain activation patterns for each disorder compared with healthy controls. In general, results showed brain activity in frontal, parietal, subcortical, and cerebellar regions; however, reduced engagement of specific nodes of the fronto-parietal network emerged in patients compared with healthy controls. In particular, neither bipolar nor depressive disorders showed detectable activations in the dorsolateral prefrontal cortices, while their parietal activation patterns were lateralized to the left and right hemispheres, respectively. On the other hand, patients with attention-deficit/ hyperactivity disorder showed a lack of activation in the left parietal lobe, whereas patients with schizophrenia showed lower activity over the left prefrontal cortex. Conclusion:These results, together with biophysical modeling, were then used to discuss the design of future disorder-specific cognitive enhancement interventions based on noninvasive brain stimulation.

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One century of healing currents into the brain from the scalp: From electroconvulsive therapy to repetitive transcranial magnetic stimulation for neuropsychiatric disorders

Cited by 9 publications

References 108 publications

Improved Interhemispheric Functional Connectivity in Postpartum Depression Disorder: Associations With Individual Target-Transcranial Magnetic Stimulation Treatment Effects

Improved Interhemispheric Functional Connectivity in Postpartum Depression Disorder: Associations With Individual Target-Transcranial Magnetic Stimulation Treatment Effects

Transcranial magnetic stimulation as an optional technique to electroconvulsive therapy in Peru

Neural correlates of N‐back task performance and proposal for corresponding neuromodulation targets in psychiatric and neurodevelopmental disorders

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