One and a half years into the COVID-19 pandemic - exit strategies and efficacy of SARS- CoV-2 vaccines for holistic management and achieving global control

Petersen, Eskild; Gökengin, Ayşe Deniz; Balushi, Asma Al; Zumla, Alimuddin

doi:10.3906/sag-2106-236

Cited by 6 publications

(4 citation statements)

References 11 publications

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“…Even though the vaccines are of great help in protecting people against SARS-CoV-2, these vaccines may not be effective against all the variants. Therefore, we should not mistakenly believe that the vaccine alone will control the pandemic [68,69]. Even when a person is vaccinated, new variants circulating in the community can cause COVID-19.…”

Section: Discussionmentioning

confidence: 99%

Attitudes and Intentions toward COVID-19 Vaccination among Spanish Adults: A Descriptive Cross-Sectional Study

Mosteiro-Miguéns¹,

Roca²,

Domínguez-Martís³

et al. 2021

Vaccines

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Vaccination against SARS-CoV-2 is postulated as the most effective measure to control the COVID-19 pandemic. However, the use of other protection measures is necessary to efficiently combat the spread of the virus. The aim of the present study was to determine the attitudes and intentions toward COVID-19 vaccination among non-regular social media users in Spain and to analyze how these factors could condition the acceptance of other personal protective measures once an individual has received the COVID-19 vaccine. A cross-sectional design was used in this work. In total, 719 subjects, ≥18 years old and of both sexes, were recruited from primary public healthcare centers to self-complete a questionnaire between March and April 2021. The majority of participants had a positive attitude toward vaccination and showed high levels of intention to be vaccinated. Likewise, except those participants who considered the vaccine to be the most effective measure to fight the COVID-19 pandemic, the rest of the participants highlighted the importance of continuing to limit social interactions and/or wearing masks even after being vaccinated. Since vaccination can create a perception of total immunity against SARS-CoV-2, it is necessary that healthcare staff organize effective awareness campaigns on the importance of maintaining personal protective measures until vaccination coverage is greater.

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Section: Discussionmentioning

confidence: 99%

Attitudes and Intentions toward COVID-19 Vaccination among Spanish Adults: A Descriptive Cross-Sectional Study

Mosteiro-Miguéns¹,

Roca²,

Domínguez-Martís³

et al. 2021

Vaccines

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“…However, there is limited data on how these variants may influence the duration and strength of immunity against subsequent infections or the longevity of vaccine-induced protection. Thus, there is a need to continuously reinforce efforts our understanding the durability of immunity in individuals exposed to different variants, including reinfection rates, and vaccine breakthrough cases remains crucial for informing vaccination strategies, booster campaigns, and long-term pandemic management [17][18][19][20][21][22][23]. This will surely enhance the capacity ability to adapt our public health measures and vaccination approaches effectively as the virus continues to evolve.…”

Section: Introductionmentioning

confidence: 99%

Managing COVID-19 Variants: Mapping Data from the International Clinical Trials Registry Platform

Ndwandwe,

Ndlovu,

Mayeye

et al. 2023

New COVID-19 Variants - Diagnosis and Management in the Post-Pandemic Era

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The COVID-19 pandemic has presented an ongoing global challenge, marked by the emergence of multiple SARS-CoV-2 variants. Effective management of these variants necessitates a comprehensive understanding of their clinical impact and the development of targeted interventions. This study explores the landscape of clinical trials giving a better understanding of the COVID-19 variants registered on the International Clinical Trials Registry Platform (ICTRP). Leveraging data from the ICTRP, we conducted an extensive mapping to assess basic characteristic features of registered clinical trials, while also giving an overview of currently used therapeutics, vaccines, and diagnostic tools specifically tailored to combat SARS-CoV-2 variants. Our analysis also provides valuable insights into the geographical distribution, trial design, and therapeutic modalities targeted at these variants. By synthesizing and visualizing this data, we aim to facilitate global collaboration, resource allocation, and evidence-based decision-making in the ongoing fight against COVID-19 variants. This chapter underscores the significance of the ITCRP registry for understanding the evolving pandemic landscape and highlights the ongoing efforts to confront the challenges posed by SARS-CoV-2 variants. The chapter also highlights essential considerations relevant to the management of COVID-19 variants in low- and middle-income countries with limited health infrastructure.

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“…Several public health interventions such as lockdown, curfew, closure and restrictions on establishment openings, personal hygiene, environmental sanitation, adequate and appropriate use of masks, and vaccination, were effective in mitigating the burden of COVID-19 [5][6][7][8][9][10][11][12][13][14][15]. Although the lack of mobilization by certain leaders combined with harsh social conditions suggest a scenario of political disarticulation that impacts the dynamics of the pandemic, such as the critical situation observed in the Brazilian state of Amazonas, the description of these perspectives allows for a panoramic evaluation of health crisis management [16].…”

Section: Introductionmentioning

confidence: 99%

Two years of COVID-19 Pandemic: Framework of Health Interventions in a Brazilian City

Faiões

Póvoa

Thurler

et al. 2022

Preprint

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The COVID-19 pandemic and its effects on public health have urgently demanded effective health policies to avoid the spread of COVID-19. Thus, public administrators have implemented non-pharmacological and pharmacological interventions to mitigate the pandemic's impacts and strengthen health services. The aim of this ecological study is to describe the scenario of COVID-19 pandemic in a Brazilian city, during two years. This ecological study was carried out in Nova Friburgo, a Brazilian city, for 105 weeks (two years), from March 29, 2020 (week 1) to April 02, 2022 (week 105). Data on COVID-19 cases and COVID-19 deaths, occupation of COVID-19 exclusive beds in hospitals, community mobility, vaccination, government regulation on the opening of city establishments and city risk assessment were collected from public datasets. Four waves of COVID-19 cases and deaths were observed during this period. The first case occurred in week 1 and first death in week 3 of this study. The highest peaks of cases and deaths were observed during the third wave with 1,131 cases (week 54) and 47 deaths (week 55) and where the highest occupation of COVID-19 exclusive beds in local hospitals occurred. Interventions from more restrictive to more flexible, were implemented throughout this study, including lockdown and gradual return in economic and social strata levels. Vaccination began on week 43 and at the end of this study 89.91% of the total population was vaccinated with at least one dose, being 83.22% fully vaccinated. A deep description of several interventions used to avoid COVID-19 spread in a Brazilian city during two years of this pandemic can help promote better decision-making in the future while it exposes the challenges of conducting public health policies in a pandemic scenario.

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One and a half years into the COVID-19 pandemic - exit strategies and efficacy of SARS- CoV-2 vaccines for holistic management and achieving global control

Cited by 6 publications

References 11 publications

Attitudes and Intentions toward COVID-19 Vaccination among Spanish Adults: A Descriptive Cross-Sectional Study

Attitudes and Intentions toward COVID-19 Vaccination among Spanish Adults: A Descriptive Cross-Sectional Study

Managing COVID-19 Variants: Mapping Data from the International Clinical Trials Registry Platform

Two years of COVID-19 Pandemic: Framework of Health Interventions in a Brazilian City

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