Oncothermia Treatment of Cancer: From the Laboratory to Clinic

Abstract

Oncothermia is a long-time applied method (since 1989) in oncology. Its clinical results excellently show its advantages, however the details of its mechanism are under investigation even today. The method is based on a self-selective process of energy concentration and targets the membrane of the malignant cell, using the temperature gradient and the beta-dispersion of the membrane proteins. To prove the theory we show the experimental evidences in vitro experiments where we showed the definite difference between the conventional heating and the oncothermia at the same temperature. In the next step, we studied some xenograft nude-mice models, verifying the temperature-dependent and non temperature dependent factors. In addition, the synergic effect with some chemotherapies were studied, having more efficacy of the oncothermia with drugs than the conventional heating. These experiments show the definite advantages of the oncothermia compared to its classical counterpart, acting on the same temperature. We have also proved the beneficial effect of oncothermia treatment in the veterinary practice Oncothermia is applied in numerous clinics and hospitals, and we would like to show some characteristic case-reports and also the clinical benefit on the survival time elongation of liver-, pancreas-, brain-, and lung-tumor-lesions.

Modulated electro-hyperthermia enhances dendritic cell therapy through an abscopal effect in mice

“…Previous studies have shown that high temperatures can damage and kill cancer cells, usually with minimal injury to normal tissues. mEHT which is also described as 'oncothermia' in Europe is a personalized treatment using energy delivery to the targeted tumor (9). This treatment concentrates the absorbed energy to intercellular electrolytes (8).…”

“…The modulated electro-hyperthermia (mEHT) system is a fast-developing complementary treatment method that is effective against different types of tumors (8,9). The principles involved are based on the classical method of hyperthermia, but the aim, besides the absolute increase in temperature, is to promote the direct absorption of electric-field energy by the extracellular fluid, thereby destroying the membrane of cancer cells.…”

“…Hyperthermia was originally controlled through modulating temperature alone, whereas the more recently developed mEHT (also described as 'oncothermia') is based on energy dose control, replacing the single temperature concept (9).…”

Newer application of Oncothermia to non-malignant diseases such as Dupuytren's contracture of the hand and chronic lower back pain lasting more than 4 weeks

“…[5]. OTM method is well proven from the laboratory level to the clinical applications, [6]. It ignites the natural processes supporting the homeostasis of the system, re-establishing the communication harmony between the cells.…”

What is on the Horizon for Hyperthermic Cancer Therapy?

“…It is a new type of heating: nanothermia. Using the above considerations, it concentrates on the nano-heating mechanism and the nano-manipulation of biomolecular changes [214,215]. It is supported by various experiments showing how energy absorption in the nano-range works.…”