Oncological risk of laparoscopic surgery in urothelial carcinomas

Rouprêt, Morgan; Smyth, Gordon; Irani, Jacques; Guy, Laurent; Davin, Jean-Louis; Saint, F.; Pfister, Christian; Wallerand, Hervé; Rozet, François

doi:10.1007/s00345-008-0349-x

Cited by 70 publications

(28 citation statements)

References 62 publications

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“…Indeed, in urothelial cancers, laparoscopy and the pneumoperitoneum may be a potential source of tumor cell spread [31]. This must be avoided by respecting the oncologic principles of open surgery, including not opening the urinary tract, gentle manipulation of tissue, and the use of an endobag.…”

Section: Discussionmentioning

confidence: 99%

The morbidity of laparoscopic radical cystectomy: analysis of postoperative complications in a multicenter cohort by the European Association of Urology (EAU)-Section of Uro-Technology

et al. 2015

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Section: Discussionmentioning

confidence: 99%

The morbidity of laparoscopic radical cystectomy: analysis of postoperative complications in a multicenter cohort by the European Association of Urology (EAU)-Section of Uro-Technology

et al. 2015

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“…It has been feared that tumor dissection during laparoscopic procedures may be associated with a higher risk of recurrence. 2 Although this remains a matter of controversy, 3 one randomized controlled trial, comparing laparoscopic nephroureterectomy (LNU) with open nephroureterectomy (ONU), showed that oncologic outcomes were comparable for both groups. 4 However, there has been no study of oncologic outcomes after LNU compared with hand-assisted laparoscopic nephroureterectomy (HALNU) and ONU for patients with UUTUC.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Laparoscopic, Hand-Assisted, and Open Surgical Nephroureterectomy

Kitamura

Maeda

Tanaka

et al. 2014

JSLS

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Background and Objectives:The aim of this study was to compare oncologic outcomes after laparoscopic nephroureterectomy, hand-assisted laparoscopic nephroureterectomy, and open nephroureterectomy for upper urinary tract urothelial cancer.Methods:Between April 1995 and August 2010, 189 patients underwent laparoscopic nephroureterectomy, hand-assisted laparoscopic nephroureterectomy, or open nephroureterectomy for upper urinary tract urothelial cancer. Of these patients, 110 with no previous or concurrent bladder cancer or any metastatic disease were included in this study. Cancer-specific survival, recurrence-free survival, and intravesical recurrence-free survival rates were analyzed by the Kaplan-Meier method and compared with the log-rank test. The median follow-up period for the cohort was 70 months (range, 6–192 months).Results:The 3 groups were well matched for tumor stage, grade, and the presence of lymphovascular invasion and concomitant carcinoma in situ. The estimated 5-year cancer-specific survival rates were 81.1%, 65.6%, and 65.2% for laparoscopic nephroureterectomy, hand-assisted laparoscopic nephroureterectomy, and open nephroureterectomy, respectively (P = .4179). The estimated 5-year recurrence-free survival rates were 33.8%, 10.0%, and 41.2% for laparoscopic nephroureterectomy, hand-assisted laparoscopic nephroureterectomy, and open nephroureterectomy, respectively (P = .0245). The estimated 5-year intravesical recurrence-free survival rates were 64.8%, 10.0%, and 76.2% for laparoscopic nephroureterectomy, hand-assisted laparoscopic nephroureterectomy, and open nephroureterectomy, respectively (P < .0001).Conclusion:Although there was no significant difference in cancer-specific survival rate among the laparoscopic nephroureterectomy, hand-assisted laparoscopic nephroureterectomy, and open nephroureterectomy groups, hand-assisted laparoscopic nephroureterectomy may be inferior to laparoscopic nephroureterectomy or open nephroureterectomy with regard to recurrence-free survival and intravesical recurrence-free survival rates.

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“…18,19 Specific worries about the pneumoperitoneum, tumor manipulation, and specimen extraction are addressed. Some experimental studies reported that laparoscopic surgery could promote tumor growth and metastases.…”

Section: Discussionmentioning

confidence: 99%

Transient Variations in the Serum Concentrations of Cell Adhesion Molecules Following Retroperitoneal Laparoscopic and Open Radical Nephrectomy for Localized Renal-Cell Carcinoma

Yang

Fan

Wang

et al. 2012

Journal of Endourology

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Although postoperatively higher serum concentrations of CAMs in both groups and significantly elevated sCD44v6 in the retro-laparoscopy group may be facilitated, the differences in CAMs between both groups are small and transient. Together with the similar follow-up results, this further supports previous studies that failed to show a difference in the oncologic outcomes between open and laparoscopic radical nephrectomy and provides a probable molecular mechanism.

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Oncological risk of laparoscopic surgery in urothelial carcinomas

Cited by 70 publications

References 62 publications

The morbidity of laparoscopic radical cystectomy: analysis of postoperative complications in a multicenter cohort by the European Association of Urology (EAU)-Section of Uro-Technology

The morbidity of laparoscopic radical cystectomy: analysis of postoperative complications in a multicenter cohort by the European Association of Urology (EAU)-Section of Uro-Technology

Comparison of Laparoscopic, Hand-Assisted, and Open Surgical Nephroureterectomy

Transient Variations in the Serum Concentrations of Cell Adhesion Molecules Following Retroperitoneal Laparoscopic and Open Radical Nephrectomy for Localized Renal-Cell Carcinoma

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