Oncological markers CA-125, CA 19-9 and endometriosis

Fiala, Luděk; Bob, Petr; Raboch, J

doi:10.1097/md.0000000000013759

Cited by 22 publications

(19 citation statements)

References 12 publications

(18 reference statements)

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“…Although in some studies have been reported that endometriosis is significantly associated with elevated serum CA19-9 and CA125 concentrations [ 15 , 17 , 33 , 34 ], the diagnostic value of serum CA125 and CA19-9 concentration in endometriosis therefore remains unclear [ 30 ]. It has been reported that CA19-9 is elevated further in the more advanced stages of endometriosis [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

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The Diagnostic Accuracy of Combined Enolase/Cr, CA125, and CA19-9 in the Detection of Endometriosis

Rokhgireh

Kashi

Chaichian

et al. 2020

BioMed Research International

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Background. The present study was designed to verify the accuracy of the noninvasive biomarkers enolase/Cr, CA125, and CA19-9 as a clinical diagnostic tool for the detection of endometriosis. Methods. A cross-sectional study was performed at Rasool-e-Akram Hospital affiliated to Iran University of Medical Sciences, Tehran, Iran, from April 2015 to April 2018. Eighty-six women were scheduled to undergo laparoscopy due to chronic pelvic pain, infertility, pelvic mass, and abnormal uterine bleeding. Serum and urine samples of all patients were collected preoperatively. Serum levels of CA125 and CA19-9, and urine levels of enolase-1 were measured. Serum levels of CA125 and CA19-9 were determined by the electrochemiluminescence method (ECL). Urinary enolase-1 was measured by the ELISA method. Result. Serum levels of CA125 and CA19-9 were significantly higher in the endometriosis group than in controls (p<0.001, p=0.004, respectively). Levels of enolase I and enolase/Cr were higher in patients with endometriosis, but the differences were not statistically significant. The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of combined enolase/Cr, CA125, and CA19-9 were 65%, 66.6%, 71%, and 60.1%, respectively. The positive likelihood ratio (PLR) and negative likelihood ratio (NLR) of combined enolase/Cr, CA125, and CA19-9 was 1.94 and 0.52, respectively. The area under the ROC curve for enolase/Cr+CA125+CA19−9 was 0.675 (95% confidence interval 0.573-0.710). Conclusion. The present study revealed that concurrent measurement of enolase-1, CA125, and CA19-9 might be a valuable noninvasive test for the identification of endometriosis.

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Section: Discussionmentioning

confidence: 99%

“…As well as recent studies report that CA 19-9 may be produced by glandular structures of the pancreas, gall bladder, bronchus, and some gynecological tumors [ 15 ]. Some studies show that CA-19-9 may be demonstrably elevated in endometriosis and show the same or decreased sensitivity as CA-125 [ 15 , 17 , 33 ].…”

Section: Discussionmentioning

confidence: 99%

The Diagnostic Accuracy of Combined Enolase/Cr, CA125, and CA19-9 in the Detection of Endometriosis

Rokhgireh

Kashi

Chaichian

et al. 2020

BioMed Research International

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“…It is well known that PCOS patients frequently reveal increased AMH-levels [16]. Moreover, as shown in the recent literature, DHEA-S levels—which were also elevated in many PCOS patients [16]—were also associated with endometriosis [17,18]. Last but not least, both diseases are linked with a lack of vitamin D and sometimes with hyperprolactinemia [19,20,21].…”

Section: Introductionmentioning

confidence: 99%

The Prevalence of Incidental Endometriosis in Women Undergoing Laparoscopic Ovarian Drilling for Clomiphene-Resistant Polycystic Ovary Syndrome: A Retrospective Cohort Study and Meta-Analysis

Hager

Wenzl

Riesenhuber

et al. 2019

JCM

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To evaluate the incidence of endometriosis in polycystic ovary syndrome (PCOS) patients who did not present with any endometriosis symptoms and underwent laparoscopic ovarian drilling (LOD) for clomiphene citrate (CC) resistance, 225 and 630 women with CC-resistant PCOS without classic endometriosis symptoms were included in a retrospective study and a meta-analysis, respectively. All women underwent LOD. The main outcome parameter was the prevalence of incidental endometriosis. Laparoscopy revealed endometriosis in 38/225 (16.9%) women (revised American Fertility Society (rAFS) stage I: 33/38, 86.8%; rAFS stage II: 5/38, 13.2%). When women with CC-resistant PCOS without endometriosis were compared, lower body mass index (BMI) and lower 25-hydroxy-vitamin D levels were associated with the presence of endometriosis at laparoscopy (odds ratios (OR): 0.872, 95% confidence intervals (95%CI): 0.792–0.960; p = 0.005 and OR: 0.980, 95%CI: 0.962–0.999; p = 0.036; respectively). The inclusion criteria for the meta-analysis were fulfilled by 4/230 reports about LOD. After correction for study heterogeneity, the pooled prevalence of incidental endometriosis was 7.7% in women with CC-resistant PCOS. In conclusion, the rate of incidental endometriosis in women with CC-resistant PCOS might reflect the prevalence of asymptomatic endometriosis. All cases were affected by minimal or mild disease. Since the literature lacks reports on associated clinical outcomes, the relevance of this entity in such patients should be the subject of further studies.

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“…Nevertheless, it was shown that there is a correlations between CA125 and carbohydrate antigen 19-9 (CA19-9) and dehydroepiandrosterone sulfate (DHEA-S) (R = 0.52 and R = 0.49). This initial result reflects that androgen-dependent increases in CA125 and CA19-9 levels are potentially significant diagnostic biomarkers of endometrial pathology [46].…”

Section: Biomarkers Associated With Endometriosismentioning

confidence: 83%

Malignant Transformation and Associated Biomarkers of Ovarian Endometriosis: A Narrative Review

et al. 2020

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This review focuses on pathogenesis of endometriosis, its possible biomarkers and role in endometriosis-associated ovarian cancer. We analyzed various databases to obtain new insights, theories, and biomarkers associated with endometriosis. There are several theories of endometriosis development and biomarker changes including atypical forms. A number of studies have attempted to establish specific, reliable biomarkers to help diagnose endometriosis and endometriosis-associated diseases on the basis of different pathogenetic pathways. Nevertheless, despite intensive research extending even to the molecular level, the origin, natural history, malignant transformation, and laboratory management of endometriosis and related diseases are not yet clearly defined. Therefore, early laboratory diagnoses of endometriosis, its atypical form, and Digital Features To view digital features for this article go to

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Oncological markers CA-125, CA 19-9 and endometriosis

Cited by 22 publications

References 12 publications

The Diagnostic Accuracy of Combined Enolase/Cr, CA125, and CA19-9 in the Detection of Endometriosis

The Diagnostic Accuracy of Combined Enolase/Cr, CA125, and CA19-9 in the Detection of Endometriosis

The Prevalence of Incidental Endometriosis in Women Undergoing Laparoscopic Ovarian Drilling for Clomiphene-Resistant Polycystic Ovary Syndrome: A Retrospective Cohort Study and Meta-Analysis

Malignant Transformation and Associated Biomarkers of Ovarian Endometriosis: A Narrative Review

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