Malignant Transformation and Associated Biomarkers of Ovarian Endometriosis: A Narrative Review

Mikhaleva, L.M.; Davydov, A.I.; Patsap, Olga I.; Mikhaylenko, Elizaveta V; Nikolenko, V. N.; Neganova, Margarita E.; Клочков, С. Г.; Somasundaram, Siva G; Aliev, Gjumrakch

doi:10.1007/s12325-020-01363-5

Cited by 32 publications

(29 citation statements)

References 192 publications

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“…EOVC arising from endometriosis was not statistically significant as an independent prognostic factor, therefore, endometriosis may be a possible precursor of EOVC but is not a factor that exacerbates cancer after its onset ( 33 ). Patients with endometriosis can be divided into several groups according to malignancy risk and there are schemes and principles used to categorize patients: ROMA (risk of ovarian malignancy algorithm), RMI (risk of malignancy index), and IOTA (International Ovarian Tumor Analysis simple rules) which are based on serum biomarkers, BMI and ultrasound findings ( 34 ).…”

Section: Hypothesis Of Eovc Originmentioning

confidence: 99%

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A Review of the Clinical Characteristics and Novel Molecular Subtypes of Endometrioid Ovarian Cancer

Chen

Qian

et al. 2021

Front. Oncol.

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Ovarian cancer is one of the most common gynecologic cancers that has the highest mortality rate. Endometrioid ovarian cancer, a distinct subtype of epithelial ovarian cancer, is associated with endometriosis and Lynch syndrome, and is often accompanied by synchronous endometrial carcinoma. In recent years, dysbiosis of the microbiota within the female reproductive tract has been suggested to be involved in the pathogenesis of endometrial cancer and ovarian cancer, with some specific pathogens exhibiting oncogenic having been found to contribute to cancer development. It has been shown that dysregulation of the microenvironment and accumulation of mutations are stimulatory factors in the progression of endometrioid ovarian carcinoma. This would be a potential therapeutic target in the future. Simultaneously, multiple studies have demonstrated the role of four molecular subtypes of endometrioid ovarian cancer, which are of particular importance in the prediction of prognosis. This literature review aims to compile the potential mechanisms of endometrioid ovarian cancer, molecular characteristics, and molecular pathological types that could potentially play a role in the prediction of prognosis, and the novel therapeutic strategies, providing some guidance for the stratified management of ovarian cancer.

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Section: Hypothesis Of Eovc Originmentioning

confidence: 99%

“…Proportions of EOVC cases with different grades and stages. there are schemes and principles used to categorize patients: ROMA (risk of ovarian malignancy algorithm), RMI (risk of malignancy index), and IOTA (International Ovarian Tumor Analysis simple rules) which are based on serum biomarkers, BMI and ultrasound findings(34).…”

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confidence: 99%

A Review of the Clinical Characteristics and Novel Molecular Subtypes of Endometrioid Ovarian Cancer

Chen

Qian

et al. 2021

Front. Oncol.

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“…Notably, the rate of recurrence in endometriosis ranges between 30 and 50% ( 3 , 4 ). In addition, numerous studies exist on the recurrence of endometriosis, which, in some instances, leads to malignant transformation to ovarian cancer ( 5 ) and reoperation. Moreover, reoperation after the recurrence of endometriosis, often damages the remaining ovarian function, causes menstrual abnormalities, amenorrhea, infertility, and an increase in costs; hence, open surgery and definite surgery (e.g., total abdominal hysterectomy bilateral salpingo-oophorectomy) may be required.…”

Section: Introductionmentioning

confidence: 99%

Dienogest as a Maintenance Treatment for Endometriosis Following Surgery: A Systematic Review and Meta-Analysis

et al. 2021

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This study aimed to comprehensively assess the value of Dienogest (DNG) as a maintenance treatment following conservative surgery for endometriosis in terms of the outcomes of disease and pregnancy. We searched for relevant studies and trials up to November 2020 from PubMed, Cochrane Library, Medline, and EMBASE databases as well as the Web of Science. Patients who received DNG maintenance treatment were compared to those who received other treatments (OT), including the levonorgestrel-releasing intrauterine system (LNG-IUS) and gonadotropin-releasing hormone analogs (GnRH-a), or non-treatment (NT). The primary outcomes were disease recurrence and pregnancy rates. Eleven studies were included in this meta-analysis. The pooled analysis indicated that DNG maintenance treatment was associated with a lower rate of disease recurrence. A significant difference was observed in DNG maintenance treatment compared with NT, but not with OT, in the pregnancy rates postoperatively. Moreover, DNG maintenance treatment was related to a significant increase in vaginal bleeding and weight gain. DNG can be recommended as a maintenance treatment for patients with endometriosis to decrease the rates of disease recurrence following conservative surgery. However, DNG maintenance treatment has no advantage in improving pregnancy rates compared to OT.

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“…MicroRNAs (miRNAs) are a class of noncoding RNAs that regulate gene expression at the post-transcriptional level. They bind to 3′-untranslated region (3′-UTR) of target mRNAs and negatively control gene translation or cause mRNA degradation [ 4 ]. It has been proven that miRNAs play a significant role in various biological processes, including the cell cycle, proliferation, differentiation, and cell apoptosis.…”

Section: Introductionmentioning

confidence: 99%

MiRNAs as Noninvasive Biomarkers and Therapeutic Agents of Pituitary Adenomas

Beylerli

Beeraka

Gareev

et al. 2020

IJMS

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Pituitary adenoma (PA) accounts for 10–15% of all intracranial neoplasms. Even though most pituitary adenomas are benign, it is known that almost 35% of them exhibit an aggressive clinical course, including rapid proliferative activity and invasion of neighboring tissues. MicroRNAs (miRNAs) are short single-stranded RNA molecules that can influence post-transcriptional regulation by controlling target genes. Based on research data on miRNAs over the past 20 years, more than 60% of genes encoding human proteins are regulated by miRNAs, which ultimately control basic cellular mechanisms, including cell proliferation, differentiation, and apoptosis. Dysregulation of miRNAs has been observed in a number of diseases, especially tumors like PA. A majority of miRNAs are expressed within the cells themselves. However, the circulating miRNAs can be detected in several biological fluids of the human body. The identification of circulating miRNAs as new molecular markers may increase the ability to detect a tumor, predict the course of a disease, plan to choose suitable treatment, and diagnose at the earliest signs of impending neoplastic transformation. Therapy of PAs with aggressive behavior is a complex task. When surgery and chemotherapy fail, radiotherapy becomes the treatment of choice against PAs. Therefore, the possibility of implementing circulating miRNAs as innovative diagnostic and therapeutic agents for PA is one of the main exciting ideas.

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Malignant Transformation and Associated Biomarkers of Ovarian Endometriosis: A Narrative Review

Cited by 32 publications

References 192 publications

A Review of the Clinical Characteristics and Novel Molecular Subtypes of Endometrioid Ovarian Cancer

A Review of the Clinical Characteristics and Novel Molecular Subtypes of Endometrioid Ovarian Cancer

Dienogest as a Maintenance Treatment for Endometriosis Following Surgery: A Systematic Review and Meta-Analysis

MiRNAs as Noninvasive Biomarkers and Therapeutic Agents of Pituitary Adenomas

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