Oncologic reconstruction: General principles and techniques

Ho, Adelyn L.; Carre, Antoine L.; Patel, Ketan M.

doi:10.1002/jso.24206

Cited by 6 publications

(7 citation statements)

References 150 publications

(195 reference statements)

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“…Although time to complete epithelialization was greater than that reported for grafting, which is between seven and 14 days, it was an expected outcome, given that ADM is a dermal scaffold and lacks the dermal layers characteristic of autologous grafts. 1,5,11 Moreover, most of the study population was elderly, many of whom tolerated reconstruction under local anesthesia only. Our study demonstrated that resection of a cutaneous malignancy with ADM coverage was well tolerated in the elderly, even under local anesthesia only, although graft failure was more frequent.…”

Section: Discussionmentioning

confidence: 99%

“…P ATIENTS WITH CUTANEOUS malignancies have several options for reconstruction after surgical excision. 1 According to prior studies, 50 to 61 per cent of patients who underwent wide local excision for skin cancer required a reconstructive procedure for defect coverage. [2][3][4] For patients with multiple medical comorbidities, these reconstructive options become limited and often require complex planning for wound closure or coverage.…”

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confidence: 99%

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Human Acellular Dermal Matrix is a Viable Alternative to Autologous Skin Graft in Patients with Cutaneous Malignancy

Lewis

Towery

Bhat

et al. 2019

The American Surgeon

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Skin substitutes have shown success in complex wound reconstruction. We evaluate the use of a human acellular dermal matrix (ADM) as a viable alternative to autologous skin grafting for defects secondary to skin cancer excision. An institutional review board–approved, retrospective review of ADM-reconstructed defects secondary to skin cancer excision between 2012 and 2018 was conducted. ADM was indicated in patients with preclusive factors for general anesthesia, protracted procedure time, reluctance for additional donor site wound, and personal choice. We reviewed defect characteristics, healing time, postoperative outcomes, and patient demographics. The 228 participants (151 males, 77 females) had a median age of 72 years (range, 29–95 years), with melanoma diagnosed in 113 (49.6%), squamous cell carcinoma in 61 (26.8%), and basal cell carcinoma in 28 (12.2%) patients. The median interval to complete epidermal coverage was 42 days, with graft failure evident in six patients (2.6%). ADM is a viable, low-morbid alternative for reconstruction of defects secondary to skin cancer excision, with no donor site morbidity. With exception to complete healing time, outcomes are similar to those of autologous grafting.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Human Acellular Dermal Matrix is a Viable Alternative to Autologous Skin Graft in Patients with Cutaneous Malignancy

Lewis

Towery

Bhat

et al. 2019

The American Surgeon

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“…Metode terapi yang efektif untuk tumor vagina eksternal meliputi eksisi operasi, cryosurgery, immunoterapi dan kemoterapi. Teknik operasi pengangkatan tumor menurut Ho et al (2016) meliputi, penanganan jaringan secara seksama, mencegah pendarahan, menjaga suplai darah, dilakukan secara aseptis, mengurangi tegangan tepi luka, aposisi tepi luka yang akurat dan mengurangi dead space yang dapat memperlambat kesembuhan luka. Penggunan scalpel yang sering digunakan dalam bedah juga dapat digantikan dengan peralatan electrosurgical yang dapat meminimalisir perdarahan dan kerusakan jaringan pada kasus bedah tumor (Leil et al, 2018).…”

Section: Pembahasanunclassified

Vaginal Fibrosarcoma in Golden Retriever Dog: Case Report

et al. 2021

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A Golden Retriever bitch, 10 years old, came to the Animal Hospital of Brawijaya University, Malang, Indonesia, her conditions was discharge from the vagina, stink smell, polyuria, polydipsia and swelling in the vaginal area that begin to appear one month ago. Physical examination results found her weight 30 kg, scored three for body condition score (scale 1-5), body temperature at 38ºC, pale mucous membrane, and Capillart Reill Time > 2 seconds. Hard mass was palpable in the vaginal area. Based on the anamnesis, physical examination and clinical symptoms, the bitch appeared have some different diagnosis such as pyometra, endometritis, vaginitis, and vaginal tumors. Hematology, radiograph, and histopathological laboratory tests were performed to confirm the diagnosis. Hematologic results showed the bitch suffered from leukocytosis of 41.7 x 103/?L, granulocytosis 36.5 x 103/?L, and hyperchromic microcytic anemia. The results of the radiograph examination showed a radiopaque solid mass in the vagina and uterus. The results of the histopathological examination found there were hyperchromasia nuclei and pleomorphism of fibroblast cell, and formation spindles cell of connective tissue. Based on the results of physical examination, hematological test, radiographic test, and histopathology, the dog was diagnosed with fibrosarcoma in the vagina. The treatment of this case was ovariohysterectomy and removal of the vaginal tumor. Early diagnosis and early treatment largely determine the patient’s prognosis, metastatic vaginal fibrosarcoma tumors showed poor prognosis.

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“…Pedicled skin flap [7,8] is heavily applied in oncologic and reconstructive surgery with the advantages of simplified procedure and reliable blood supply. However, in many cases, a giant defect or a large defect cannot be covered or covered properly with a certain single pedicled flap.…”

Section: Introductionmentioning

confidence: 99%

Multiple pedicled flaps cover for large defects following resection of malignant tumors with partition concept

Shen

et al. 2017

Medicine

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Large defects after skin malignant tumors resection were difficult to repair. We introduced a partition concept, in which the large defects were divided into several subunits, and each subunit was repaired by a certain pedicled flap to achieve a complete coverage.Between May 2012 and Oct 2016, 8 patients with skin malignant tumors underwent radical resection. Prior to surgery, the dimension of the potential defect after tumor ablation was estimated and outlined. After evaluation, the partition concept was applied and the defects were divided into several subunits. Also, the rationality of the choice of pedicled flap was evaluated. Each flap was used to cover its specific subunits defect.After excision, the defect areas were from 13 × 17 cm to 36 × 23 cm. Each subunit was designed to be repaired with a pedicled flap, which included local random flap, superficial iliac artery flap, transverse rectus abdominis myocutaneous (TRAM) flap, lateral thoracic advanced island flap, anterolateral thigh (ALT) flap, anteromedial thigh (AMT) flap, and deep circumflex iliac artery (DCIA) flap. Primary closure of both donor and recipient sites was achieved in all patients. All the flaps survived. Flap necrosis was not observed.Reconstruction of large defects following resection of malignant tumors with multiple pedicled flaps was a reliable method. The partition concept is useful in the reconstruction of large tumor wounds in 1-stage operation.

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Oncologic reconstruction: General principles and techniques

Cited by 6 publications

References 150 publications

Human Acellular Dermal Matrix is a Viable Alternative to Autologous Skin Graft in Patients with Cutaneous Malignancy

Human Acellular Dermal Matrix is a Viable Alternative to Autologous Skin Graft in Patients with Cutaneous Malignancy

Vaginal Fibrosarcoma in Golden Retriever Dog: Case Report

Multiple pedicled flaps cover for large defects following resection of malignant tumors with partition concept

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