2007
DOI: 10.2174/157016207781023974
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Oncogenic Properties of HIV-Tat in Colorectal Cancer Cells

Abstract: With the advent of Highly-Active-Anti-Retroviral-Therapy (HAART), HIV patients can expect to live beyond 10-15 years following diagnosis. An unexpected result of increased survival is the emergence of opportunistic, oncogenic virus-associated cancers such as Burkitt's lymphoma (Epstein-Barr Virus), cervical cancer (Human Papilloma Virus) and Kaposi's sarcoma (Kaposi's sarcoma-associated herpesvirus) in this immuno-compromised population. Furthermore, there are reports of colorectal cancers (CRC) in long-term H… Show more

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Cited by 18 publications
(12 citation statements)
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References 28 publications
(43 reference statements)
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“…Direct oncogenic effects of the virus itself could also be implied. Indeed, in vitro experiments suggest that the tat HIV protein could interfere with DNA repair mechanisms and apoptosis increasing the risk of malignant transformation in the host cells [33,34]. However, clinical studies are discordant about the risk of NADM and their relation to HIV viral load.…”
Section: Discussionmentioning
confidence: 99%
“…Direct oncogenic effects of the virus itself could also be implied. Indeed, in vitro experiments suggest that the tat HIV protein could interfere with DNA repair mechanisms and apoptosis increasing the risk of malignant transformation in the host cells [33,34]. However, clinical studies are discordant about the risk of NADM and their relation to HIV viral load.…”
Section: Discussionmentioning
confidence: 99%
“…In the context of HIV-Associated Nephropathy, Tat protein increased albumin permeability and rapidly induced the redistribution and loss of nephrin in isolated glomeruli [107]. Furthermore, studies investigating other HIV-Associated conditions such as HIV-Associated Thrombocytopenia, Pulmonary vesicular remodeling as well as Cancer development suggest that HIV-1Tat protein plays significant role in the pathological progression of those diseases [108-111]. …”
Section: Reviewmentioning
confidence: 99%
“…Colorectal cancer does not have a known viral etiology. Interestingly, Tat may play a role in development of this type of cancer in HIV-1-infected patients [ 23 ]. The mechanism underlying this effect of Tat has to be yet fully elucidated and we present below one possible mechanism how Tat may affect cellular processes, which are closely related to cancer development.…”
Section: Aids and Cancermentioning
confidence: 99%