2011
DOI: 10.1186/1743-422x-8-269
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Oncogenic potential of Human Papillomavirus (HPV) and its relation with cervical cancer

Abstract: Human Papillomavirus (HPV) is the most common cause of cervical cancer. Cervical cancer being the second most common cancer after lung cancer, affecting women of different age groups; has a prevalence of about 20% in young sexually active women. Among different types of HPV, HPV16 the major strain causing this cancer and is sexually transmitted had been unnoticed for decades. Keeping in mind the multiple risk factors related with cervical cancer such as early age sexual activities, teenage pregnancies, smoking… Show more

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Cited by 143 publications
(120 citation statements)
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References 70 publications
(71 reference statements)
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“…The product of E5 could downregulate the histocompatibility leucocyte antigen (HLA) expression of the infected cells, facilitating virus immune escape (13,14). E6 and E7 are considered as tumorigenic genes; their products could bind to tumor suppressor protein p53 and arrest cell cycle, impairing the infected cells apoptosis and enhancing their transformation (15). The L1 and L2 proteins are responsible for forming the structural components of the viral capsid.…”
Section: Effect Of Human Papillomavirus Infection On the Immune Systementioning
confidence: 99%
“…The product of E5 could downregulate the histocompatibility leucocyte antigen (HLA) expression of the infected cells, facilitating virus immune escape (13,14). E6 and E7 are considered as tumorigenic genes; their products could bind to tumor suppressor protein p53 and arrest cell cycle, impairing the infected cells apoptosis and enhancing their transformation (15). The L1 and L2 proteins are responsible for forming the structural components of the viral capsid.…”
Section: Effect Of Human Papillomavirus Infection On the Immune Systementioning
confidence: 99%
“…Since it is very difficult to realize a longitudinal study that might include patients without any cytological anomalies for decades in order to see the relationship between GST M1 and T1 genetic polymorphisms and HPV HR infections, the present study has included HPV-HR positive patients with LSIL, HSIL or in situ carcinoma, which, accordingly to the known HPV natural history (1,2,4,5,22,23), are due to persistent HPV-HR that cause significant squamous cell modifications.…”
Section: Discussionmentioning
confidence: 99%
“…Cervical neoplasia is the second most prevalent cancer in women after lung cancer, representing one of the major morbidity causes, especially in young women (1,2). Scientific medical research over the past two decades has brought conclusive and unquestionable evidence that cervical neoplasia results from persistent chronic infections with oncogenic types of the human papilloma virus (HPV) known as high-risk HPV (hrHPV).…”
Section: Genetic Polymorphisms Of Glutathione S Transferase and Cervimentioning
confidence: 99%
“…In addition to HPV infection, other factors affect the development of CC, including immunological disorders and genetic malfunctions such as point mutations, deletions, amplifications and rearrangements of DNA (6). Previous studies have suggested that epigenetic changes may significantly impact cervical carcinogenesis (6)(7)(8)(9).…”
Section: Introductionmentioning
confidence: 99%
“…CC is a gynecological malignancy associated with oncogenic human papillomavirus (HPV) infection (6,7). In addition to HPV infection, other factors affect the development of CC, including immunological disorders and genetic malfunctions such as point mutations, deletions, amplifications and rearrangements of DNA (6).…”
Section: Introductionmentioning
confidence: 99%