Oncogenic osteomalacia in a patient with an ethmoid sinus tumour

Kurien, Regi; Manipadam, M.T.; Rupa, Vedantam

doi:10.1017/s0022215109992313

Cited by 9 publications

(7 citation statements)

References 19 publications

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“…Here we present a detailed review of published English literature for TIO cases involving head and neck region ( n = 163) (5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, …”

Section: Discussionmentioning

confidence: 99%

Tumor induced osteomalacia in head and neck region: single center experience and systematic review

Shah

Lila

Jadhav

et al. 2019

Endocrine Connections

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Tumor-induced osteomalacia in the head and neck region remains a challenging diagnosis to manage. Literature pertaining to management and outcome details remains sparse. We describe two cohorts: cohort 1 included seven patients from a single center in Western India with tumors located in paranasal sinuses (n = 3), intracranial (n = 2) and maxilla (n = 2). The unique features from our series is the management of persistent disease with radiation therapy (n = 2) and peptide receptor radionuclide therapy (PRRT) (n = 1). Cohort two has 163 patients identified from 109 publications for systematic review. Paranasal sinuses, mandible, intracranial disease, maxilla and oral cavity, in descending order, are reportedly common tumor sites. Within this cohort, mean age was 46 ± 14 years at presentation with 44.1% having local symptoms. Duration of symptoms varied from 1 to 240 months. Pre-surgery mean serum phosphorus was 1.4 ± 0.4 mg/dL and median FGF-23 levels were 3.6 (IQR:1.8–6.8) times of normal upper limit of normal. Majority (97.5%) were managed primarily with surgical excision; however, primary radiotherapy (n = 2) and surgery combined with radiotherapy (n = 2) were also reported. Twenty patients had persistent disease while nine patients had recurrence, more commonly noted with intracranial and oral cavity tumors. Surgery was the most common second mode of treatment employed succeeded by radiotherapy. Four patients had metastatic disease. The most common histopathological diagnosis reported is PMT mixed connective tissue, while the newer terminology ‘PMT mixed epithelial and connective tissue type’ has been described in 15 patients.

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Section: Discussionmentioning

confidence: 99%

Tumor induced osteomalacia in head and neck region: single center experience and systematic review

Shah

Lila

Jadhav

et al. 2019

Endocrine Connections

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“…Now, octreotide scans combined with venous FGF23 sampling has been conWrmed to be a very useful method for localizing the oVending tumor [7,8]. Since tumors in TIO arising in craniofacial sinuses are extremely rare, especially when the patients had no relative symptoms, it is even more diYcult to localize [3,[10][11][12]. Most tumors associated with TIO are slow-growing, benign, polymorphous neoplasms of mesenchymal origin, classiWed as phosphaturic mesenchymal tumor, in which mixed connective tissue variant is the most common.…”

Section: Discussionmentioning

confidence: 99%

Osteomalacia caused by tumors in facies cranii mimicking rheumatoid arthritis

Wang

Zhong

et al. 2011

Rheumatol Int

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Tumor-induced osteomalacia (TIO) is an extremely rare metabolic bone disease and the occult offending tumor arising in facies cranii is even more uncommon. In this report, we described 2 middle-aged females with TIO caused by the tumor in facies cranii, which had ever been misdiagnosed as rheumatoid arthritis. Case 1 was present with diffuse bone pain and muscle weakness for 4 years, as well as esotropia in the right eye for 1 month. Case 2 was present with progressive bone pain in low back and hip for 2 years. Biochemical studies both showed persistent hypophosphatemia and urinary over wasting phosphate. Radiological examinations revealed the infiltrative mass in right apex partis petrosae ossis temporalis in case 1, and the soft mass in left nasal cavity and ethmoid sinuses in case 2, respectively. The offending tumors were resected completely in case 2, however, incompletely in case 1. Pathology examination revealed mixed connective tissue variant phosphaturic mesenchymal tumors. In conclusion, TIO should be presumed in patients presenting with unexplained persistent hypophosphatemia osteomalacia, also a thorough detection for tumor in facies cranii should be performed.

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“…Other specific osseous entities can also be associated with OO including osteosarcoma, enchondroma, nonossifying fibroma, and hemangioma [18,[31][32][33][34][35][36][37][38][39]. The documentation in these reports has usually been sufficient to histologically rule out PMTMCT.…”

Section: Phosphaturic Mesenchymal Tumors: Othersmentioning

confidence: 99%

Striking Pathology Gold: A Singular Experience with Daily Reverberations: Sinonasal Hemangiopericytoma (Glomangiopericytoma) and Oncogenic Osteomalacia

Brandwein-Gensler

Siegal

2012

Head and Neck Pathol

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Oncogenic osteomalacia in a patient with an ethmoid sinus tumour

Abstract: Oncogenic osteomalacia secondary to a paranasal sinus neoplasm is a rare entity. The causative tumour is often occult and may be missed by routine clinical examination. This case report illustrates the appropriate pattern of evaluation and management to ensure a successful outcome.

Cited by 9 publications

References 19 publications

Tumor induced osteomalacia in head and neck region: single center experience and systematic review

Tumor induced osteomalacia in head and neck region: single center experience and systematic review

Osteomalacia caused by tumors in facies cranii mimicking rheumatoid arthritis

Striking Pathology Gold: A Singular Experience with Daily Reverberations: Sinonasal Hemangiopericytoma (Glomangiopericytoma) and Oncogenic Osteomalacia

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