Striking Pathology Gold: A Singular Experience with Daily Reverberations: Sinonasal Hemangiopericytoma (Glomangiopericytoma) and Oncogenic Osteomalacia

Abstract

Sinonasal hemangiopericytoma-like tumors(SN

Glomangiopericytoma Versus Solitary Fibrous Tumor: an Omental Tumor with Unusual Diagnostic Dilemma

“…The neoplastic cells are uniform and elongated to oval, with round to spindle-shaped nuclei and lightly eosinophilic cytoplasm with indistinct cell membranes imparting a syncytial appearance. [7,9,14] In addition to spindle cells, occasional tumors have foci with a more round-cell appearance, resembling glomus tumor, as observed in our case. [8] Generally there is low mitotic activity and nuclear pleomorphism is absent or minimal.…”

Update on Select Benign Mesenchymal and Meningothelial Sinonasal Tract Lesions

“…The majority of patients experience nasal obstruction and epistaxis, with a wide range of other non-specific findings (polyps, sinusitis, headaches, difficulty breathing, congestion), usually present for less than 1 year on average. Severe oncogenic osteomalacia occurring in association with GPC is reported [11,15]. GPCs are indolent tumors, with an overall excellent survival ([90 % 5-year survival) achieved with complete surgical excision.…”

Phosphaturic Mesenchymal Tumor Involving the Head and Neck: A Report of Five Cases with FGFR1 Fluorescence In Situ Hybridization Analysis

“…Despite this, both tumors demonstrated histologic features typical of PMT including multi-nucleated giant cells and flocculent calcifications. On the contrary, some patients who present with TIO are found to have tumors that have histologic features that overlap between PMT and other soft tissue tumors of the head and neck such as glomangiopericytoma [8]. In our opinion, these tumors warrant ancillary molecular investigations such as FISH to confirm the presence of a translocation in FGFR1 or CISH to detect increased expression of FGF23.…”

“…Tumors involving the head and neck are extremely rare [3,[5][6][7][8][9]. Half of all PMTs reported in the head and neck have involved the sinonasal tract; other sites include the pharynx, maxilla, mandible, tongue, floor of mouth, and posterior neck.…”