Oncocytic lipoadenomatous tumours of salivary glands

Oncocytic Lipoadenoma of the Salivary Gland: A Clinicopathologic Analysis of 7 Cases and Review of the Literature

“…The tumor has thus far not been documented in minor salivary glands. Based on present data and other reports, oncocytic lipoadenoma appears to be a benign tumor with no risk or recurrence or aggressive behavior (mean follow up 40 months) [12,14,18,19,[22][23][24].…”

“…Mixed lipomatous and epithelial tumors where the latter component is comprised of oncocytes have been termed oncocytic lipoadenoma, which appear to be unique to salivary glands. Oncocytic lipoadenoma is rare; to date twenty cases have been reported in the literature (Table 2) [12][13][14][15][16][17][18][19][20][21][22][23][24]. The ''adenoma'' designation highlights the predominance of the epithelial component, rather than sialolipoma which emphasizes the fatty component.…”

“…Patients typically present with a painless, slowly growing mass or swelling that has not uncommonly been present for an extended duration of time (mean 34.5 months; range 2-180 months) [12,14,15,[17][18][19][20][21]23]. The vast majority of oncocytic lipoadenomas have originated in the parotid gland, with only few reports of submandibular gland involvement [12,16,22]. The tumor has thus far not been documented in minor salivary glands.…”

“…The oncocytes are usually arranged in nests and acini with a microscopic appearance resembling a conventional oncocytoma. The lipomatous component of the tumor has the appearance of mature adipose tissue and can comprise as little as 5 % to as much as 80 % of the tumor volume [12][13][14][15][16][17][18][19][20][21][22][23][24]. The adipocytes may be relatively evenly dispersed among the oncocytes, or may be irregularly distributed with either the oncocytic or lipomatous component predominating in a given area of the tumor.…”

“…First described in 1998, oncocytic lipoadenoma is a histologically distinctive tumor composed of oncocytic cells and mature adipocytes [12]. The tumor is decidedly rare; with only a few examples in the literature, mostly as case reports [13][14][15][16][17][18][19][20][21][22][23][24]. With scant published data, we analyzed seven new cases of oncocytic lipoadenoma in order to further delineate the clinicopathologic features of this unusual salivary gland neoplasm, combined with a thorough review of the literature.…”