Oncocytic carcinoma of the salivary gland with thymoma: A case report and review of the literature

Abstract

Oncocytic carcinoma (OC) arising in the salivary gland is a very rare tumor with only 32 previously reported cases. In this report, we describe a novel case of oncocytic carcinoma with associated thymoma, which arose in the left parotid gland of a 66-year-old male with a history of a painless left parotid mass for 1 year. Oncocytes are large, polygonal cells that are characterized by marked cellular atypia, frequent mitoses, wide eosinophilic granular cytoplasm, a central nucleus and a prominent nucleolus. The follow-up data showed no evidence of recurrence and the patient is in a good health 20 months after the surgery. In the current case, the patient had not only OC but also thymoma, which is exceedingly rare and may represent the first documented case in the literature.

Proliferaciones Oncocíticas de Glándulas Salivales: Estudio Estructural e Inmunohistoquímico de 7 Casos

“…Su contraparte maligna, el carcinoma oncocítico, es la entidad más importante en el diagnóstico diferencial del oncocitoma. En el primero se producen metástasis en nodos linfoides regionales y a distancia, invasión perineural e intravascular, mitosis, polimorfismo celular y destrucción de tejidos adyacentes (Cao et al, 2015;Westergaard-Nielsen et al, 2018).…”

Oncocytic carcinoma of the major salivary glands: A population‐based study of 278 cases

“…Oncocytic carcinoma of the salivary glands is very rare, with fewer than 100 cases reported in the English literature since Bauer and Bauer's first description in 1953, approximately 0.05% of all salivary gland tumors . These tumors may arise de novo or from previous oncocytomas.…”