Oncocytes, Oxyphils, Hürthle, and Askanazy Cells: Morphological and Molecular Features Of Oncocytic Thyroid Nodules

Mete, Özgür; Sylvia, L.

doi:10.1007/s12022-009-9102-2

Cited by 64 publications

(59 citation statements)

References 61 publications

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“…11 Because oncocytic change exhibits a spectrum of degrees of mitochondrial accumulation, the clinicopathological significances of oncocytic change …”

Section: Discussionmentioning

confidence: 99%

“…[22][23][24] Furthermore, some studies have shown that desmoplastic or inflammatory stromal reaction appears to be associated with a relatively poor prognosis of PTC. 11 Although the definite pathogenesis of desmoplastic reactions is still unclear, inflammatory cytokines from adipose tissue and adipocyte-derived fibroblasts contribute to the desmoplastic reaction in breast cancer. 25,26 In the present study, desmoplasia did not show any correlation with the presence of lymph node metastasis or the tumour stages.…”

Section: Discussionmentioning

confidence: 99%

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Implications of oncocytic change in papillary thyroid cancer

Hong

et al. 2016

Clinical Endocrinology

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SummaryObjective Although the presence of oncocytic change in less than 75% of a tumour is not considered to indicate oncocytic variants of papillary thyroid carcinoma (PTC), we frequently observe partial oncocytic change, especially in obese PTC patients. Thus, we sought to investigate the relationship between the presence of oncocytic change of PTC and its prognosis. Design, setting and participants We retrospectively studied 142 patients with PTC who had undergone surgery between 2000 and 2005, and re-evaluated their PTC slides to record the proportion of oncocytic change in 10% increments from 0% to 100%. Major outcome measure We analysed the relationship between the proportion of oncocytic change and clinicopathological prognostic factors. Results Oncocytic change was found in 45Á8% (65/142) of PTC patients. The proportion of patients with oncocytic change was higher in obese patients than in lean patients and showed a significant correlation with the BMI (r = 0Á195, P = 0Á020). The PTC patients with oncocytic change showed a higher recurrence rate than PTC patients without oncocytic change (30Á8% vs 11Á7%, respectively; P = 0Á005). The presence of oncocytic change in PTC patients was associated with a shorter disease-free survival in a Kaplan-Meier analysis after a mean follow-up of 8Á9 years. Conclusion The patients with PTC with oncocytic change presented with a higher recurrence rate and were more likely to be obese. These findings suggest that presence of oncocytic change is a poor prognostic factor in PTC patients, even if the oncocytic change involves less than 75% of a tumour.

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“…11 Because oncocytic change exhibits a spectrum of degrees of mitochondrial accumulation, the clinicopathological significances of oncocytic change …”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Implications of oncocytic change in papillary thyroid cancer

Hong

et al. 2016

Clinical Endocrinology

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“…Hü rthle cells represent a form of metaplasia where thyrocytes become enlarged and display a pink, granular cytoplasm and a hyperchromatic nucleus with a prominent nucleolus (56). The cytoplasmic granularity is caused by the increased number of mitochondria that appear abnormal in size, shape, and content on analysis by electron microscopy (57).…”

Section: Discussionmentioning

confidence: 99%

Hashimoto's Thyroiditis: Celebrating the Centennial Through the Lens of the Johns Hopkins Hospital Surgical Pathology Records

Caturegli

Remigis

Chuang

et al. 2013

Thyroid

139

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Hashimoto's thyroiditis is now considered the most prevalent autoimmune disease, as well as the most common endocrine disorder. It was initially described in 1912, but only rarely reported until the early 1950s. To celebrate this centennial, we reviewed the surgical pathology archives of the Johns Hopkins hospital for cases of Hashimoto's thyroiditis, spanning the period from May 1889 to October 2012. Approximately 15,000 thyroidectomies were performed at this hospital over 124 years. The first surgical case was reported in 1942, 30 years after the original description. Then, 867 cases of Hashimoto's thyroiditis were seen from 1942 to 2012, representing 6% of all thyroidectomies. Hashimoto's thyroiditis was the sole pathological finding in 462 cases; it accompanied other thyroid pathologies in the remaining 405 cases. The most commonly associated pathology was papillary thyroid cancer, an association that increased significantly during the last two decades. The most common indication for thyroidectomy was a thyroid nodule that was cytologically suspicious for malignancy. Hashimoto's thyroiditis remains a widespread, intriguing, and multifaceted disease of unknown etiology one century after its description. Advances in the understanding of its pathogenesis and preoperative diagnosis will improve recognition and treatment of this disorder, and may one day lead to its prevention.

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“…Unlike their follicular counterpart, oxyphilic cells may feature nuclear enlargement and pleomorphism either in benign neoplasms or even in hyperplastic lesions. The most paradigmatic case is represented by hyperplastic nodules in CAT which may show a striking nuclear pleomorphism of the oxyphilic component [1,2,41,42,43,44,45,46,47,48,49]. Some authors have attempted to correlate the atypia of oxyphilic cells (and some other features such as transgressing vessels) with the risk of malignancy, but their results are still debatable [47,49].…”

Section: Oxyphilic (Hürthle Cell) Lesionsmentioning

confidence: 99%

Liquid-Based Cytology in Fine-Needle Aspiration Biopsies of the Thyroid Gland

Fadda

Rossi²

2011

Acta Cytologica

122

148

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Objectives: Fine-needle aspiration biopsy is regarded as the most important diagnostic tool for thyroid lesions because of its simplicity, safety, and cost-effectiveness. However, its pivotal role in the correct characterization of the majority of nodules is impaired by the difficulties in discriminating benign from malignant follicular-patterned lesions. Study Design: Liquid-based cytology (LBC) is a semiautomated device that has recently become widely available and has gained popularity as a method of collecting and processing both gynecologic and nongynecologic cytologic specimens. It achieves a diagnostic sensitivity as accurate as conventional preparations, especially for its excellent cell preservation and lack of background which decrease the amount of inadequate diagnoses. Results: In many cases the cytologic features are similar in both methods, but the colloid film and the lymphocytic component are more easily evaluated on direct smears whereas nuclear details and colloid globules are better evaluated in LBC slides. The material stored in the preservative solution could be effectively used for the application of immunocytochemical and molecular techniques. Conclusions: LBC-processed biopsies represent a valid alternative to conventional cytology. The possibility of applying additional techniques enhances the efficacy of the cytologic diagnosis of thyroid lesions.

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Oncocytes, Oxyphils, Hürthle, and Askanazy Cells: Morphological and Molecular Features Of Oncocytic Thyroid Nodules

Cited by 64 publications

References 61 publications

Implications of oncocytic change in papillary thyroid cancer

Implications of oncocytic change in papillary thyroid cancer

Hashimoto's Thyroiditis: Celebrating the Centennial Through the Lens of the Johns Hopkins Hospital Surgical Pathology Records

Liquid-Based Cytology in Fine-Needle Aspiration Biopsies of the Thyroid Gland

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