Hashimoto's Thyroiditis: Celebrating the Centennial Through the Lens of the Johns Hopkins Hospital Surgical Pathology Records

Caturegli, Patrizio; Remigis, Alessandra De; Chuang, Kelly; Dembele, Marieme; Iwama, Akiko; Iwama, Shintaro

doi:10.1089/thy.2012.0554

Cited by 145 publications

(111 citation statements)

References 59 publications

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“…Secondary HT is usually the result of drug-induced immune responses. Primary HT is the most common form of thyroiditis; it has a wide pathologic variety and includes six forms: Classic (8), juvenile (9) and immunoglobulin G4-dependent HT (10), the fibrous variant, Hashitoxicosis and painless thyroiditis (10,11), and its etiology has remained elusive. The common feature in all types of HT is lymphocyte infiltration and fibrosis (12,13).…”

Section: Introductionmentioning

confidence: 99%

Association of CTLA-4 gene polymorphisms −318C/T and +49A/G and Hashimoto's thyroidits in Zahedan, Iran

et al. 2016

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Abstract.Hashimoto's thyroiditis (HT) is a chronic inflammation of the thyroid gland and is known as the most common autoimmune disease. Development of autoimmune destruction of thyroid cells is a multi-step process involving convergence of genetic and environmental factors. Cytotoxic T-lymphocyte antigen-4 (CTLA-4) has an important role in homeostasis and negative regulation of immune responses, and is therefore considered to be a key element in the development of autoimmune diseases. The present study evaluated the association of the CTLA-4 gene polymorphisms 318C/T (rs5742909) and +49A/G (rs231775) with HT in an Iranian population (including 82 patients with HT and 104 healthy controls who were referred for routine premarital blood screenings). Genotyping was performed using the tetra-primer amplification refractory mutation system polymerase chain reaction technique. No significant differences were observed in genotype and allele frequencies in the single nucleotide polymorphisms (SNPs) between cases and controls. In the cases as well as in the controls, the TT genotype in the -318C/T polymorphism was absent and the predominant genotype was CC, while the predominant genotype for the +49A/G SNP was AA. As only few studies in this field have assessed Iranian and even Middle Eastern populations, additional studies with a higher number of samples are recommended to further assess the impact of -318C/T (rs5742909) and +49A/G (rs231775) polymorphisms of CTLA-4 on HT.

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Section: Introductionmentioning

confidence: 99%

Association of CTLA-4 gene polymorphisms −318C/T and +49A/G and Hashimoto's thyroidits in Zahedan, Iran

et al. 2016

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“…Although, once considered a pathologic curiosity 22 , this pattern of histopathology is now recognized by the term "lymphoid neo-genesis with tertiary lymphoid organ formation" and has been implicated in the pathogenesis of a very wide range chronic inflammatory and autoimmune disease. That includes rheumatoid arthritis 23 , Hashimoto's thyroiditis 24 , Sjogren's syndrome 25 , chronic Lyme disease 26 and many others diseases 27 . Although difficult to find in lung tissue from non-smokers, about 5% of the airways examined in smokers with normal lung function contain tertiary lymphoid organs with no further increase observed in either mild (GOLD-1) or moderate (GOLD-2) COPD patients 21 .…”

Section: The Local Tissue Response In Lungs Affected By Copdmentioning

confidence: 99%

Small Airways Disease in Chronic Obstructive Pulmonary Disease: A 50 Years History

Hogg¹,

Hackett²

2017

BRN

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Macklem and Mead provided the first direct evidence that the small conducting airways < 2 mm in diameter accounted for less than 10% of the total lower airway resistance in 1967. This seminal report was followed by Hogg, Macklem, and Thurlbeck's 1968 report that confirmed and extended these observations by showing that the same small airways that offer so little resistance to airflow in normal human lungs become the major site of obstruction in patients with emphysema. These and other observations led Mead to postulate that these small conducting airways represent a "quiet" zone within the normal lung where disease can accumulate over many years without being noticed. This brief review revisits this hypothesis within the context of work reported in the 50 years since Macklem and Mead published their work. With special emphasis on why these small conducting airways are vulnerable to the development of disease.

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“…[1][2][3] The histological characteristics of this disease include the presence of a diffuse lymphocytic infiltrate in the thyroid gland accompanied by a variable degree of fibrosis.…”

Section: Introductionmentioning

confidence: 99%

Hashimoto’s disease in a cohort of 29 children and adolescents. Epidemiology, clinical course, and comorbidities in the short and long term

López

Nso-Roca

Ruíz

et al. 2018

Arch Argent Pediatr

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Hashimoto's thyroiditis is the most common cause of goiter and hypothyroidism among children and adolescents. Its clinical manifestations and course vary. The objective of this study was to review the clinical and evolutionary characteristics of Hashimoto's disease in the pediatric population. Clinical, analytical, ultrasound, epidemiological, and evolutionary data of patients with autoimmune thyroiditis seen at Hospital Universitario San Juan de Alicante between January 2010 and January 2016 were analyzed. A total of 29 patients were included in the study. A higher prevalence of girls was observed, at a 2:1 ratio. The main reason for consultation was the accidental detection of high thyroid stimulating hormone levels or positive anti-thyroid antibodies in a lab test done for other reason. In the initial analysis, 53.3% of patients had subclinical hypothyroidism and only 10% of them had frank hypothyroidism. Two patients developed thyroid cancer. INTRODUCTIONHashimoto's thyroiditis is the most common cause of thyroid disease among children and adolescents. [1][2][3] The histological characteristics of this disease include the presence of a diffuse lymphocytic infiltrate in the thyroid gland accompanied by a variable degree of fibrosis.Its clinical manifestations at the time of diagnosis and clinical course vary. Most patients have no symptoms and a normal thyroid function at the time of diagnosis. Among symptomatic patients, the most common clinical manifestations are goiter and growth retardation. This disease is characterized by the presence of anti-thyroid peroxidase (TPO) antibodies and anti-thyroglobulin (TG) antibodies in blood. A thyroid hormone analysis and ultrasound are useful to make a complete diagnosis of these patients.The objective of this study was to review the clinical and evolutionary characteristics of Hashimoto's disease in a pediatric population. POPULATION AND METHODSHospital Universitario San Juan de Alicante sees patients from the Department of Health 17 of the Valencian Community and caters for a population of 220 000 inhabitants, with over 33 000 children and adolescents younger than 15 years.A descriptive, retrospective study was done in a cohort of patients diagnosed with autoimmune thyroiditis before 18 years old and seen at the Department of Pediatrics of Hospital Universitario San Juan de Alicante between January 2010 and January 2016.The study was approved by the hospital's Ethics Committee.The medical records of patients with final diagnosis of Hashimoto's thyroiditis or disease, autoimmune thyroiditis or hypothyroidism or chronic lymphocytic thyroiditis were included. presence of anti-thyroid antibodies; their followup included a complete physical examination and a thyroid function test every 6 months and labs, including complete autoimmunity testing, every year. An ultrasound was done initially and then twice-yearly. Different clinical, analytical, and ultrasound outcome measures were analyzed. The most important outcome measures included year and age at the time of d...

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Hashimoto's Thyroiditis: Celebrating the Centennial Through the Lens of the Johns Hopkins Hospital Surgical Pathology Records

Cited by 145 publications

References 59 publications

Association of CTLA-4 gene polymorphisms −318C/T and +49A/G and Hashimoto's thyroidits in Zahedan, Iran

Association of CTLA-4 gene polymorphisms −318C/T and +49A/G and Hashimoto's thyroidits in Zahedan, Iran

Small Airways Disease in Chronic Obstructive Pulmonary Disease: A 50 Years History

Hashimoto’s disease in a cohort of 29 children and adolescents. Epidemiology, clinical course, and comorbidities in the short and long term

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