Glioblastoma is an aggressive central nervous system tumor with a
5-year-survival rate of less than 10%. Patients diagnosed with the disease are
treated with surgery, radiation and temozolomide chemotherapy. Despite survival
benefits, patients eventually relapse. There is a need for new treatments with
improved efficacy. Imipridone ONC201 is a small molecule originally identified
as a TNF-related apoptosis inducing ligand (TRAIL)-inducing compound. ONC201 has
the unique ability to induce expression of both pr…
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