On Water CuSO₄. 5H₂O-catalyzed Synthesis of 2-amino-4H-chromenes

Abstract

Sustainable development is a balance between environment and development. Sustainable development requires sustainable supplies of clean, affordable, and renewable energy sources that do not cause negative impact to the society. This article introduces a green chemistry method to synthesize 2-amino-4H-chromenes that reduces or eliminates the use and generation of hazardous substances in the design, manufacture, and application of chemical products. This method is described using copper (II) sulfate pentahydrate, as a green and reusable catalyst on water. The products were obtained at very good yields, short reaction time, and at lower cost than other reported procedures.

Triethanolamine‐catalyzed expeditious and greener synthesis of 2‐amino‐4H‐chromenes

“…The structure of the product 4a was confirmed by comparison of the melting points and through thin‐layer chromatography (TLC) with an authentic sample prepared by following a reported method and also by spectral data (IR, mass spectrometry, and 1 H NMR).…”

“…Moreover, other catalysts such as methanesulfonic acid, imidazole, porous organic polymers (POPs), potassium phthalimide, l ‐proline‐melamine, sodium malonate, and Na 2 CO 3 have also been utilized for this transformation. In recent years, several new green methods have been reported using cetyltrimethylammonium chloride, KF/Al 2 O 3, basic γ–alumina, MgO, CuSO 4 ·5H 2 O, DBU, CTABr/ultrasound irradiation, nanocatalyst, bael fruit extract (BFE), water extract of lemon fruit shell ash (WELFSA), and poly(ethylene glycol) (PEG) in water . Although various procedures for the synthesis of 2‐amino‐4 H ‐chromenes are known, many of these methods have disadvantages such as expensive and unique catalysts, long reaction times, utilization of microwave or ultrasonic irradiation, and affording only moderate yields .…”

Copper‐Catalysed Multicomponent Syntheses of Heterocycles

“…Behbahani and co‐workers developed a copper(II) sulphate catalysed green synthetic strategy for the synthesis of 2‐amino‐4 H chromenes . This reaction is found to be appealing due to the short reaction time and reusable green catalyst in water.…”

Nickel Oxide-Catalyzed Synthesis of 4-Amino-2H-Chromenes: Its Application in Antimicrobial Studies and Towards Protein Docking

“…The synthesis of 2-amino-4H-chromenes has already been prepared by heating a mixture of malono-nitrile, aldehyde and activated phenol in the presence of hazardous organic bases such as piperidine [10]. Although different synthetic methods are available to prepare these heterocyclic systems using methane sulphonic acid, preyssler heteropoly acid, ammonium acetate, N,N-dimethylamino-functionalized basic ionic liquid, CuSO 4 •5H 2 O, DBU, chitosan, p-toluene sulfonic acid, Ca(OH) 2 , nano-magnesium oxide, hexadecyltrimethyl ammonium bromide (HTMAB), polyamine catalyst, 2,2,2-trifluoroethanol, Mg/Al hydrotalcite, microwave-assisted, DBU, PbO, nitriles have been reviewed [11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28]. To the best of our knowledge there is no report in the literature using green NiO nanoparticle as a catalyst for the synthesis of 2-amino-4H-chromenes.…”