On the utility and limitations of fine‐needle aspiration of palpable lesions located in the hand

García‐Solano, José; García‐Rojo, Blas; Sánchez‐Sánchez, Carlos M.; Montalbán-Romero, Socorro; Martínez-Parra, Diego; Pérez‐Guillermo, Miguel

doi:10.1002/1097-0339(200010)23:4<284::aid-dc14>3.3.co;2-5

Cited by 6 publications

(15 citation statements)

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“…9 The 15 different types of malignant soft tissue tumor we encountered in these acral sites during the study period are also many more than any single published study on the distal extremity 5,7-9 and, likewise, probably a bias of our particular patient population. Only 2 of our cases (1.4%) were superficial primary skin tumors, in contrast with the study by García-Solano et al, 7 who performed 20% of their FNABs on superficial skin lesions of the hand. Their diagnostic rate for skin lesions appears similar to that for their deep-seated soft tissue tumors, and they conclude that the sensitivity of FNAB could be increased by additionally obtaining scrapings of the lesions to complement the aspiration material.…”

Section: Specific Cytologic Diagnosis (No Of Cases) No (%) Of Casescontrasting

confidence: 87%

“…Only cases with tissue biopsy confirmation or a minimum of 1-year clinical followup were included in this study. We included the following cases from previously published studies by our group: 8 cases from an FNAB series of high-grade sarcoma, 13 7 cases from a series of soft tissue myxomas, 11 3 cases from a series of nodular fasciitis, 18 and 2 cases from a series of extraskeletal myxoid chondrosarcoma. 12 Upon completion of this activity you will be able to: • cite the most common benign and malignant soft tissue lesions and their location in the distal extremity.…”

Section: Methodsmentioning

confidence: 99%

“…One reason for this may be the infrequency of malignancy in this location (<2% of all cases). [2][3][4][5][6][7][8][9][10] Previously, only 2 studies have specifically commented on the use of FNAB in the hand and wrist. 7,8 And, with the exception of scattered case reports or distal extremity cases reported within larger series, FNAB of the foot and ankle region has been largely neglected.…”

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confidence: 99%

“…[2][3][4][5][6][7][8][9][10] Previously, only 2 studies have specifically commented on the use of FNAB in the hand and wrist. 7,8 And, with the exception of scattered case reports or distal extremity cases reported within larger series, FNAB of the foot and ankle region has been largely neglected. [11][12][13][14][15][16][17] The purpose of this study is to report our experience with FNAB of the upper and lower distal extremities.…”

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confidence: 99%

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Fine-Needle Aspiration Biopsy of the Distal Extremities

2010

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We reviewed our cytopathology databases for an 11-year period to identify all fine-needle aspiration biopsy (FNAB) cases of palpable masses of the hand, wrist, ankle, or foot. Cases were included only if there was a subsequent tissue biopsy or a minimum 1-year clinical follow-up. Of 141 aspirates, 41, 23, 34, and 43 were from the hand, wrist, ankle, and foot, respectively. Specific benign or malignant diagnoses were achievable in 71.6% of cases, whereas the remaining cases were given a descriptive diagnosis (26.2%) or, infrequently, a "suspicious for" diagnosis (2.1%). Overall sensitivity and specificity for distinguishing a benign from malignant entity from all 4 sites were 100% and 96%, respectively, whereas positive and negative predictive values were 88% and 100%, respectively. The most common lesion was a ganglion. Of the benign neoplasms, giant cell tumor of tendon sheath (17) and desmoid-type fibromatosis (7) were most common. Of 31 malignancies, 24 were sarcomas: sarcoma not otherwise specified (6), high-grade pleomorphic sarcoma (5), and Ewing sarcoma (3) were most common. Seven nonsarcomas included melanoma (3), metastatic squamous carcinoma (2), and malignant lymphoma (2). An FNAB-procured cytopathologic diagnosis is clinically reliable in a high percentage of distal extremity mass lesions.

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Section: Specific Cytologic Diagnosis (No Of Cases) No (%) Of Casescontrasting

confidence: 87%

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

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confidence: 99%

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Fine-Needle Aspiration Biopsy of the Distal Extremities

2010

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“…2 Several factors have been implicated such as the low volume of soft tissue and bone lesions in most practices, the overlapping cytomorphologic features in a variety of entities, and the wide variability in reported sensitivities, specificities, and inadequacy rates over the past 2 to 3 decades, [2][3][4][5][6][7][8][9][10][11][12][13][14] leading to skepticism regarding the accuracy and utility of this technique. [15][16][17] The aims of the current study were to investigate the utility of FNA in the diagnosis of soft tissue and bone lesions in a large series of cases from a tertiary medical center with an active FNA service, and to highlight some of the challenges.…”

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confidence: 99%

Diagnostic accuracy and limitations of fine‐needle aspiration cytology of bone and soft tissue lesions

Khalbuss

Teot

Monaco

2010

Cancer Cytopathology

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BACKGROUND: Fine-needle aspiration (FNA) cytology is increasingly being used as a diagnostic modality for soft tissue and bone lesions. These diagnoses can be challenging because of a variety of factors, including interpretation and sampling issues. This study investigates the diagnostic utility of FNA biopsy, in addition to the diagnostic pitfalls, in soft tissue and bone cytopathology. METHODS: We retrospectively reviewed the soft tissue and bone FNAs over a 4-year period (2004)(2005)(2006)(2007)(2008), along with available ancillary studies, pathological follow-up, and clinical data. The cases with a cytologic-histologic discrepancy were then reviewed. RESULTS: A total of 1114 soft tissue and bone FNAs were identified. Of the 1114 aspirates, 525 (47%) were positive for malignant cells, 505 (45.5%) were benign aspirates (including 189 benign lesions/neoplasms), 37 (3.5%) were inadequate, 34 (3%) had atypical cells, and 13 (1%) were suspicious for malignancy. Of the 586 cases (53%) with follow-up, including 445 cases with histological follow-up and 141 with ancillary studies, the overall sensitivity was 96%, the specificity was 98%, the positive predictive value was 99%, and the negative predictive value was 92%. A total of 15 false negatives and 3 false positives were identified with errors because of sampling (9 cases), interpretation (7 cases), and screening (2 cases). CONCLUSIONS: This large series demonstrates that there can be a high sensitivity and specificity in diagnosing bone and soft tissue lesions by FNA. Our data supports prior studies in the literature in showing that FNA cytology can be a valuable method for diagnosing these lesions. Cancer (Cancer Cytopathol) 2010;118:24-32.

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Diagnostic utility of fine‐needle aspiration cytology of lesions involving bone

Maisel

Frank

et al. 2017

Diagnostic Cytopathology

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Our findings indicate that FNA of bone lesions is a useful diagnostic technique with high sensitivity, particularly when the cytologic findings are interpreted in conjunction with the core biopsy and pertinent clinical and radiologic findings. In addition, ROSE followed by open, dynamic communication with the performing radiologist leads to an extremely low rate of inadequate core biopsy specimens, resulting in optimal patient diagnosis and management. Diagn. Cytopathol. 2017;45:608-613. © 2017 Wiley Periodicals, Inc.

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On the utility and limitations of fine‐needle aspiration of palpable lesions located in the hand

Cited by 6 publications

References 0 publications

Fine-Needle Aspiration Biopsy of the Distal Extremities

Fine-Needle Aspiration Biopsy of the Distal Extremities

Diagnostic accuracy and limitations of fine‐needle aspiration cytology of bone and soft tissue lesions

Diagnostic utility of fine‐needle aspiration cytology of lesions involving bone

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