Diagnostic utility of fine‐needle aspiration cytology of lesions involving bone

Yu, Gordon H.; Maisel, Julia; Frank, R.T.; Pukenas, Bryan; Sebro, Ronnie; Weber, Kristy

doi:10.1002/dc.23735

Cited by 13 publications

(12 citation statements)

References 46 publications

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“…Numerous publications have reported that CT-guided percutaneous core-needle biopsy is a well-established technique and is effective for the initial diagnosis of musculoskeletal lesions, with a measured diagnostic yield ranging between 70 and 89% and a reported accuracy between 61 and 98% [2–11]. These results confirm the high sensitivity of CT-guided percutaneous needle biopsy for the diagnosis of bone tumors through the use of a minimally invasive procedure, which is associated with cost savings and fewer biopsy complications than open surgical biopsy [6, 7, 10–14]. However, the disadvantage of this guided biopsy method is that metabolically active lesions without distinctive morphology may not be reliably assessable by CT-guided biopsy, and the false-negative biopsy rate of such lesions may be substantially higher with CT-guided biopsy [15].…”

Section: Introductionmentioning

confidence: 57%

PET/CT-guided versus CT-guided percutaneous core biopsies in the diagnosis of bone tumors and tumor-like lesions: which is the better choice?

Xiao

Liu

et al. 2019

Cancer Imaging

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ObjectiveThe present study aimed to evaluate the diagnostic performance and safety of PET/CT-guided percutaneous core bone biopsy and to compare the PET/CT-guided method to conventional CT-guided percutaneous core biopsies to diagnose Chinese patients with bone tumors and tumor-like lesions.MethodsData for 97 patients with bone tumors and tumor-like lesions diagnosed by percutaneous core bone biopsy from February 2013 to November 2018 were retrospectively analyzed. The study included 42 cases in the PET/CT group and 55 cases in the CT alone group. The diagnostic performance, cost and complications associated with the intervention were compared between the two groups. All patients were eventually confirmed to have bone tumors and tumor-like lesions according to surgical pathology findings.ResultsThere were no significant differences in patient characteristics (P > 0.05). For the patients in the PET/CT group, the overall diagnostic yield of the initial biopsies and the diagnostic accuracy derived from the surgically proven cases were both 97.62%, which was significantly higher than the values in the CT group during the same period (P < 0.05). No major biopsy-related complications (e.g., serious bleeding or tumor dissemination) occurred before, during, or after the intervention. Therefore, no significant difference was observed between the two groups with regard to the complication rate (P > 0.05).ConclusionCompared with CT-guided percutaneous bone biopsy, PET/CT-guided percutaneous bone biopsy is an effective and safe alternative with high diagnostic performance in the evaluation of hypermetabolic bone lesions to diagnose bone tumors and tumor-like lesions.

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Section: Introductionmentioning

confidence: 57%

PET/CT-guided versus CT-guided percutaneous core biopsies in the diagnosis of bone tumors and tumor-like lesions: which is the better choice?

Xiao

Liu

et al. 2019

Cancer Imaging

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“…Currently, the frequently used biopsy technologies mainly include ne-needle aspiration, core needle biopsy, incision biopsy, and excision biopsy. Owing to the involvement of small trauma, less complications, lower cost, and ease of operation, the rst two technologies are favored by bone oncologists [25,26] . However, there are several other factors that affect the diagnosis rate with the use of these two approaches.…”

Section: Discussionmentioning

confidence: 99%

Chondroblastoma of the Patella with Secondary Aneurysmal Bone Cyst, an Easily Misdiagnosed Bone Tumor: A Case Report with Literature Review

Zheng¹,

Niu²,

Shi³

et al. 2020

Preprint

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Background: Chondroblastoma (CB) is a rare, primary, benign bone tumor that common affects men aged 15-20 years. It is usually detected in the epiphysis of the long bones, such as the proximal femur, humerus, and tibia. However, CB is extremely rare in the patella, especially in combination with secondary aneurysmal bone cyst (ABC). In fact, this complicated condition can be easily confused with other common bone tumors of the patella. Case presentation: We have presented here the case of a 30-year-old man who was suffering from the anterior knee pain for the past 6 months that got aggravated since the past 2 weeks. Osteolytic bone destruction in the patella could be detected in both his X-ray and computed tomography (CT) examinations, while the magnetic resonance imaging (MRI) detected a fluid level. Accordingly, secondary ABC was presumed. We diagnosed the condition as giant cell tumor (GCT) with secondary ABC and accordingly performed curettage inside the focus region by autogenous bone grafting in accordance with the patient's medical history, physical manifestations, results of physical and ancillary examinations, and the disease characteristics. However, the in- and postsurgical outcomes indicated that the patient’s histopathology was consistent with that of typical CB, suggesting a definitive error in diagnosis. Accordingly, the patient was finally diagnosed with patella CB along with secondary ABC.Conclusions: Past studies have demonstrated that the 3 commonest bone tumors affecting the patella are GCT, CB, and ABC. We believe that the condition of patella GCT and CB accompanied with secondary ABC can be easily misdiagnosed. Performing incision biopsy or excision biopsy and conducting histological examination may be the most effective approach to identify and distinguish among these diseases.

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“…36 Although it has several advantages, such as the cost, speed, and ease of performing, and it has already shown high sensitivity in the biopsy of several other organs, FNA is not often used for the biopsy of MSK tumors. 45,46 The main reason is the structure and heterogeneity of the mesenchymal tumors that have similarities and can overlap cytomorphologically, and the low quantity of obtained material that is insufficient for various morphological, immunohistochemical, or molecular analyses. 45,46 Several studies showed low accuracy of FNA in the biopsy of MSK tumors compared with core needle biopsy, whereas others claimed a high sensitivity.…”

Section: Factors Associated With Success Of the Imaging-guided Biopsymentioning

confidence: 99%

“…45,46 The main reason is the structure and heterogeneity of the mesenchymal tumors that have similarities and can overlap cytomorphologically, and the low quantity of obtained material that is insufficient for various morphological, immunohistochemical, or molecular analyses. 45,46 Several studies showed low accuracy of FNA in the biopsy of MSK tumors compared with core needle biopsy, whereas others claimed a high sensitivity. 45,46 Therefore FNA is usually reserved for the diagnosis of metastases or recurrent tumors that were previously documented, 47 and some centers do not perform it at all.…”

Section: Factors Associated With Success Of the Imaging-guided Biopsymentioning

confidence: 99%

“…45,46 Several studies showed low accuracy of FNA in the biopsy of MSK tumors compared with core needle biopsy, whereas others claimed a high sensitivity. 45,46 Therefore FNA is usually reserved for the diagnosis of metastases or recurrent tumors that were previously documented, 47 and some centers do not perform it at all. However, other authors reported high sensitivity of FNA.…”

Section: Factors Associated With Success Of the Imaging-guided Biopsymentioning

confidence: 99%

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Percutaneous Imaging-Guided versus Open Musculoskeletal Biopsy: Concepts and Controversies

Nikodinovska

Ivanoski

Samardziski

et al. 2020

Semin Musculoskelet Radiol

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Bone and soft tissue tumors are a largely heterogeneous group of tumors. Biopsy of musculoskeletal (MSK) tumors is sometimes a challenging procedure. Although the open biopsy is still considered the gold standard for the biopsy of MSK lesions, core needle biopsy can replace it in most cases, with similar accuracy and a low complication rate. The biopsy should be performed in a tertiary sarcoma center where the multidisciplinary team consists of at minimum a tumor surgeon, an MSK pathologist, and an MSK radiologist who can assess all steps of the procedure. Several factors can influence the success of the biopsy including the lesion characteristics, the equipment, and the method used for the procedure. This review highlights some of the important aspects regarding the biopsy of the MSK tumors, with special attention to imaging a guided core needle biopsy and highlighting some of the recent advancements and controversies in the field.

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Diagnostic utility of fine‐needle aspiration cytology of lesions involving bone

Cited by 13 publications

References 46 publications

PET/CT-guided versus CT-guided percutaneous core biopsies in the diagnosis of bone tumors and tumor-like lesions: which is the better choice?

PET/CT-guided versus CT-guided percutaneous core biopsies in the diagnosis of bone tumors and tumor-like lesions: which is the better choice?

Chondroblastoma of the Patella with Secondary Aneurysmal Bone Cyst, an Easily Misdiagnosed Bone Tumor: A Case Report with Literature Review

Percutaneous Imaging-Guided versus Open Musculoskeletal Biopsy: Concepts and Controversies

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